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Hyung-Min Kwon 1 Article
Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease
Soo Hyun Jang, Hyejin Lee, Jun Suk Kim, Hyun Jung Park, Su Min Jeong, Sang-Hyun Lee, Hyun Ho Kim, Jin Ho Park, Dong Wook Shin, Jae Moon Yun, BeLong Cho, Hyung-Min Kwon
Korean J Fam Med 2015;36(5):227-232.   Published online September 18, 2015
DOI: https://doi.org/10.4082/kjfm.2015.36.5.227
Background

Small vessel disease is an important cause of cerebrovascular diseases and cognitive impairment in the elderly. There have been conflicting results regarding the relationship between Helicobacter pylori infection and ischemic stroke. This study aimed to examine the association between H. pylori infection and cerebral small vessel disease.

Methods

The study included 1,117 patients who underwent brain magnetic resonance imaging and H. pylori identification between 2005 and 2013 at Health Promotion Center, Seoul National University Hospital. Multivariable logistic regression analysis was used to assess the association between H. pylori infection and small vessel disease with adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, body mass index, smoking status, problem drinking, and antiplatelet use.

Results

The adjusted odds ratios (aORs) for the association between H. pylori infection and silent brain infarction and cerebral microbleeds were 1.03 (95% confidence interval [CI], 0.66-1.61) and 0.70 (95% CI, 0.38-1.28), respectively. The aORs for silent brain infarction and cerebral microbleeds were 0.81 (95% CI, 0.44-1.44) and 0.59 (95% CI, 0.30-1.18) in patients aged <65 years and 1.59 (95% CI, 0.78-3.22) and 1.89 (95% CI, 0.38-9.33) in those aged >65 years, respectively. Moreover, the aORs for silent brain infarction and cerebral microbleeds were 0.96 (95% CI, 0.54-1.71) and 0.74 (95% CI, 0.33-1.69) in H. pylori-infected patients without atrophic gastritis and 0.89 (95% CI, 0.48-1.62) and 0.99 (95% CI, 0.43-2.27) in those with atrophic gastritis, respectively.

Conclusion

No association between H. pylori infection and small vessel disease was observed. H. pylori-induced inflammation may not be a risk factor for microcirculatory damage in the brain.

Citations

Citations to this article as recorded by  
  • Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old
    Yinjie Guo, Canxia Xu, Linfang Zhang, Zhiheng Chen, Xiujuan Xia
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients
    Mohamed Fahmy Doheim, Ahmad Amr Altaweel, Mohamed Gamal Elgendy, Alaa Ahmed Elshanbary, Mahmoud Dibas, Amira Abo Hegil Abo Ali, Toqa Mahmoud Dahy, Atef Khairy Sharaf, Ameer E. Hassan
    Journal of Neurology.2021; 268(9): 3238.     CrossRef
  • DAPT score: predictive model of dual-antiplatelet therapy for acute cerebral infarction
    Yang Liu, Jia Yang, Panpan Jiang, Shan Wang, Mingming Wang, Mayan Wang, Tiankang Guo, Jianxiong Liu
    Neurological Sciences.2021; 42(2): 681.     CrossRef
  • Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
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    Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
  • Serum Level of Helicobacter pylori Antibody in Stroke Patients
    Shahir Mazaheri, Mojtaba Khazaei, Abbas Moradi, Reza Raei
    Avicenna Journal of Clinical Medicine.2020; 26(4): 206.     CrossRef
  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community
    Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
    Neurology Clinical Practice.2018; 8(3): 223.     CrossRef
  • Helicobacter pylori and extragastric diseases
    Elisabetta Goni, Francesco Franceschi
    Helicobacter.2016; 21(S1): 45.     CrossRef
  • Update on prevention and treatment of Helicobacter pylori infection
    Zhao-Chun Chi
    World Chinese Journal of Digestology.2016; 24(16): 2454.     CrossRef
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Korean J Fam Med : Korean Journal of Family Medicine
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