Citations

• Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study
  Byoung-Jin Park, Yong-Jae Lee, Hye-Ree Lee, Dong-Hyuk Jung, Ha-Young Na, Hong-Bae Kim, Jae-Yong Shim
  Korean Journal of Family Medicine.2012; 33(4): 190.     CrossRef

Despite wide acceptance of the idea of 'evidence based medicine (EBM)', there is still a huge gap between evidence and clinical practice. Pre-appraised resources help clinicians find correct answers to clinical questions more easily and rapidly. It will briefly explain the concept and history of EBM. Frequently used pre-appraised resources like as systematic review, evidence based guidelines, health technology assessment, synopses, and clinical information database systems are also introduced.

Citations

• Designing Digital Therapeutic Content Using Chronic Disease Data: A Focus on Improving Urinary Dysfunction
  Jungjo Na, Su Jin Kim, Yangmi Lim
  International Neurourology Journal.2023; 27(Suppl 2): S51.     CrossRef
• Analysis of Unstructured Data on Detecting of New Drug Indication of Atorvastatin
  Hwee-Soo Jeong, Gil-Won Kang, Woong Choi, Jong-Hyock Park, Kwang-Soo Shin, Young-Sung Suh
  Journal of Health Informatics and Statistics.2018; 43(4): 329.     CrossRef
• Research Trend of Nurses' Job Stress: A Comparative Study
  Yunjeong Yi, Bokim Lee
  Korean Journal of Occupational Health Nursing.2013; 22(1): 13.     CrossRef

Background
Diet pattern of regular and three meals per day is commonly recommended. Studies investigated the health effect of gorging pattern of diet using meal frequency and meal skipping, but the health effect of meal calorie variation between three regular meals has never been investigated. In this study, maximum meal calorie variation was defined as subtraction calorie for a meal with minimum energy intake from calories for a meal with maximum energy intake between three meals and examined the effect of maximum meal calorie variation between three regular meals a day on cardiovascular risk factors. Methods: A total of 4,680 healthy subjects aged 20-87 years who underwent medical screening examination, at one tertiary hospital health screening center and completed 24-hour dietary recall was included. Serum cholesterol subfractions, fasting glucose and blood pressure were measured.Results: Maximum meal calorie variation was significantly related to serum concentration of total cholesterol (Ղ = 1.77; 95% confidence interval [CI], 0.36 to 3.18) and low density lipoprotein-cholesterol (LDL-C) (Ղ = 1.64; 95% CI, 0.37 to 2.91), body mass index (Ղ = 0.24; 95% CI, 0.12 to 0.37) and waist circumference (Ղ = 0.66; 95% CI, 0.34 to 0.98) after adjustment for potential confounders. Conclusion: This study suggests the notion that concentration of total cholesterol and LDL-C and obesity indices are related to maximum meal calorie variation between three meals, independently of energy intake and other confounding factors in free-living population.

Citations

• Metabolic profile in women with bulimia nervosa or binge-eating disorder before and after treatment: secondary analysis from the randomized PED-t trial
  Therese Fostervold Mathisen, Jorunn Sundgot-Borgen, Jan H. Rosenvinge, Solfrid Bratland-Sanda, Mette Svendsen, Gunn Pettersen, KariAnne Vrabel, Oddgeir Friborg
  Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2023;[Epub]     CrossRef

Background
Metabolic syndrome is a cluster of several metabolic disorders (central obesity, dyslipidemia, hyperglycemia, and hypertension). It is closely related to the cardiovascular risk factors. ENPP1 is an inhibitor of insulin-induced activation of the insulin receptor. The aim of this study was to investigate the association between ENPP1 K121Q polymorphism and metabolic syndrome in Korean.Methods: We measured BMI, waist circumference, blood pressure, lipid profile, fasting glucose in the participants who visited Health Promotion Center, Jeju National University Hospital from February to July 2008. ENPP1 K121Q polymorphism was determined by restriction fragment-length polymorphism polymerase chain reaction in 84 patients with metabolic syndrome and 114 control group. Results: The frequencies of ENPP1 K121Q polymorphism were 27.4% in metabolic syndrome and 9.6% in control group. BMI, waist circumference, blood pressure were increased in male K121Q group and triglyceride was increased in female K121Q group.Conclusion: K121Q polymorphism was more frequent in the patients with metabolic syndrome among Koreans. There were differences of the metabolic components according to the genotype. It supports the K121Q polymorphism was associated with the genetic susceptibility for metabolic syndrome.

Background
Gastroscopy is the useful method to detect the upper gastrointestinal condition, but examinee have recognized it as the procedure causing the discomfort and anxiety. This study was conducted to identify the factors related to pre-procedural anxiety for gastroscopy .Methods: From 9th March to 12th June 2009, Data were collected from 463 examinee undergone gastroscopy at a health promotion center of a university hospital by self-administered questionnaires about general characteristics (age, sex, education state, economic state, family history of gastric cancer), gastrointestinal symptom, histroy of gastrointestinal disease, sedated gastroscopy and previous experience of gastroscopy. Before gastroscopy procedure, pre-procedural anxiety was assessed using 20-items by Korean version of Spielberger State Triat Anxiety Inventory Form-Y (STAI-Y).Results: The mean score of pre-procedural state anxiety was 38.1 ± 10.2 in all participants. The mean score was the most highest in participants who had no previous experience of gastroscopy and would perform non-sedated gastroscopy as 42.1 ± 10.3. Factors related to pre-procedural anxiety were female (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.94 to 4.64), low education state (OR, 1.68; 95% CI, 1.05 to 2.71) and the previous experience of gastroscopy (OR, 0.46; 95% CI, 0.24 to 0.88). Among participants who had the previous experienced gastroscopy, female (OR, 3.20; 95% CI, 1.97 to 5.22), low education state (OR, 1.79; 95% CI, 1.06 to 3.02) and the good tolerance at previous gastroscopy (OR, 0.35; 95% CI 0.21 to 0.59) were related to pre-procedural anxiety. Conclusion: In health check examinee, female, low education state and the no previous experience of gastroscopy were related to pre-procedural anxiety. Endoscopists should be provide efforts to lower pre-procedural anxiety in those subjects as to increase effectiveness of interventions.

Citations

• Anxiety, Nursing Satisfaction Level, and Experience of Users of The General Health Checkup Center: A Mixed Methods Study
  Eun Kook Kim, Hyejin Hyun, Yeon Jeong Heo
  Journal of Korean Association for Qualitative Research.2024; 9(3): 242.     CrossRef
• Translation and validation of modified dental anxiety scale based on adult Taiwan population
  Chia-Shu Lin, Chen-Yi Lee, Shih-Yun Wu, Li-Ling Chen, Kun-Tsung Lee, Min-Ching Wang, Tze-Fang Wang
  BMC Oral Health.2021;[Epub]     CrossRef
• The Effect of Behavioral Relaxation Training on Distress and Cancer Screening Intention of Patients with Upper Gastrointestinal Endoscopy
  Hyo Yeon Nam, Hyung Wha Shim
  Journal of Korean Academic Society of Nursing Education.2019; 25(4): 414.     CrossRef

Background
A number of observational studies have found that ginseng intake may reduce the risk of developing gastric cancer. However, studies have yielded inconsistent results as to whether consuming ginseng can lower the risk of gastric cancer. We conducted a meta-analysis of studies that assessed the association between ginseng intake and the risk of gastric cancer.Methods: We searched MEDLINE, EMBASE, CINAHL, KMbase, KoreaMed, RiCH, National Assembly Library, Riss4u, and DBPIA for studies released through August 2007. We manually searched the references. Two authors independently extracted the data. To assess the quality of the studies Scottish Intercollegiate Guidelines Network (SIGN) Methodology Checklist for case-control studies and cohort studies were used. Review Manager 5.0 (RevMan) was used for statistical analysis.Results: We identified one case-control study and three cohort studies. The risk ratio (RR) for ginseng intake of all studies was 0.83 (95% confidence interval [CI], 0.46 to 1.51) and I2 = 91% for heterogeneity. We did subgroup analysis according to different types of study design, nation, and author. The results were consistent only when we did subgroup analysis according to authors. The RR of subgroup by different authors was 1.43 (95% CI, 1.10 to 1.80) and I2 = 0% without showing heterogeneity.Conclusion: In this meta-analysis, the results suggested that there was insufficient evidence to confirm the association between ginseng intake and the risk of gastric cancer. Subsequent more powerful, well-designed, and larger observational epidemiological studies are needed to clarify the association.

Citations

• Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses
  Jin Long Liang, Hui Ming Yuan, Chao Quan, Jun Qiang Chen
  Frontiers in Oncology.2025;[Epub]     CrossRef
• Nutritional supplements
  Hyun Ah Park, Soo Young Kim
  Journal of the Korean Medical Association.2012; 55(9): 889.     CrossRef

Infectious diseases imported from other countries have increased. Feco-oral route is the most common mode of transmission for both typhoid fever and hepatitis A, and thus infection by these agents have an association with poor sanitation. A 30-year-old male was visited to the hospital because of high fever after traveling in Thailand. The level of hepatic transaminases were mildly elevated and viral serological marker for hepatitis was negative. The blood culture was reported positive for Salmonella typhi. After a few days, the level of hepatic transaminases rapidly increased and viral serological marker for hepatitis became positive with anti-hepatitis A viral IgM at follow-up. Therefore we report a case of co-infection of S. typhi and viral hepatitis A after traveling abroad.