Background It is well known that breastfeeding has a significant impact on the health of mothers and children. With the growing importance of breastfeeding, the present study aimed to investigate the relationship between breastfeeding and the prevalence of diabetes in Korean parous women.
Methods The data of 5,448 premenopausal parous women aged 20–49 years who agreed to participate in the 5th– 6th Korea National Health and Nutrition Examination Survey were analyzed in this study. Control group included women who had not breastfed. The subjects who had breastfed were classified into three groups based on the duration of breastfeeding: 0–6 months, 6–12 months, and >12 months. The variables included age, body mass index, education level, income, alcohol drinking, smoking, family history of diabetes, use of oral contraceptives, the number of pregnancies, and regular exercise.
Results Among the subjects, the prevalence of diabetes was significantly lower in women who had breastfed compared to those who had not, with an odds ratio of 0.534 (95% confidence interval [CI], 0.289–0.976) in women who breastfed for 0–6 months and 0.575 (95% CI, 0.321–0.990) in women who breastfed for 6–12 months (both P<0.05).
Conclusion The present study found a reduced prevalence of diabetes in women who had breastfed compared to those who had not. However, no association between the duration of breastfeeding and the prevalence of diabetes could be found.
Citations
Citations to this article as recorded by
Association of Childbirth and Breastfeeding with Diabetes Mellitus in Korean Women Seulkee Kim, So Yeon Ryu Journal of Health Informatics and Statistics.2024; 49(2): 109. CrossRef
Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases Rozeta Sokou, Stavroula Parastatidou, Zoi Iliodromiti, Katerina Lampropoulou, Dionysios Vrachnis, Theodora Boutsikou, Aikaterini Konstantinidi, Nicoletta Iacovidou Nutrients.2023; 15(13): 2822. CrossRef
The relationship between pregnancy count and duration of breast-feeding with metabolic syndrome (Fasa Persian cohort study) Saeideh Zareei, Fatemeh Behrasi, Mohammad Mehdi Naghizadeh, Fatemeh Talebzadeh, Ali Kharmandar, Mojtaba Farjam, Reza Homayounfar BMC Women's Health.2023;[Epub] CrossRef
Development and validation of breastfeeding and dietary education package for women with gestational diabetes mellitus Farhanah Ahmad Shuhaimi, Syahrul Bariah Abdul Hamid, Nurul Ainfarhanah Md Yazid Journal of Education and Health Promotion.2023;[Epub] CrossRef
Breastfeeding and cardiovascular risk factors Deepak Bhatnagar, Prachi Bhatnagar Current Opinion in Lipidology.2019; 30(1): 45. CrossRef
Breastfeeding Can Reduce the Risk of Developing Diabetes Soo Young Kim Korean Journal of Family Medicine.2018; 39(5): 271. CrossRef
Background Epidemiological studies suggest that serum calcium levels correlate with cardiovascular events. An ankle-brachial index (ABI) between 0.9 and 1.00 is a surrogate estimation of preclinical peripheral arterial disease (PAD). Prior studies have shown that an ABI of 0.9–1.0 is also associated with endothelial dysfunction. Therefore, we sought to investigate the relationship between serum calcium levels and preclinical PAD in apparently healthy Korean individuals.
Methods We evaluated the association between serum calcium levels and preclinical PAD in 596 participants (334 males, 262 females) in a health examination program. Preclinical PAD was defined by an ABI of 0.9–1.0. Multiple logistic regression analysis was used to determine whether the serum calcium level was an independent determinant of preclinical PAD.
Results The overall prevalence of preclinical PAD was 14.3%. The mean age was 44.0±12.5 years in the non-PAD group and 48.3±11.4 years in the preclinical PAD group (P=0.001). After adjusting for age, gender, systolic blood pressure, fasting plasma glucose, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, g-glutamyltransferase, uric acid, hypertension medication, diabetes medication, and hyperlipidemia medication, the odds ratio (95% confidence intervals) for preclinical PAD was 2.28 (1.02–5.11) with a 1-mg/dL increase in the serum calcium.
Conclusion These findings suggest that increased serum calcium is independently and positively associated with preclinical PAD regardless of the presence of classic cardiovascular risk factors.
Background Metabolic syndrome (MS) is a well-known risk factor of cardiovascular diseases that is focused on central obesity. Recent studies have reported the association between pericardial adipose tissue (PAT) volume and MS. However, no studies have demonstrated the cutoff PAT volume that represents the best association with MS.
Methods The data of 374 subjects were analyzed cross-sectionally to compare PAT, measured on coronary multidetector computed tomography, and various metabolic parameters according to MS. After PAT volumes were divided into tertiles, various metabolic parameters were compared among tertiles; furthermore, the odds ratio for developing MS was calculated. Finally, we demonstrated the cutoff PAT volume that represented the best association with MS by using the receiver-operating characteristic curve.
Results We found that 27.5% of the subjects had MS, and the mean PAT volume was 123.9 cm3 . PAT showed a significant positive correlation with body mass index, waist circumference, and levels of glucose, triglyceride, high-sensitivity C-reactive protein, uric acid, and homocysteine, but a negative correlation with high-density lipoprotein cholesterol. Furthermore, after dividing into tertiles, PAT volume was also significantly associated with various metabolic parameters. The odds ratio for having MS was 4.19 (95% confidence interval, 2.27–7.74) in the top tertile of PAT volumes after adjusting for age, sex, and smoking. The cutoff PAT volume that represented the best association with MS was 142.2 cm3 .
Conclusion PAT was significantly associated with MS and various metabolic parameters. The cutoff PAT volume of 142.2 cm3 showed the best association with MS.
Background Dry eye syndrome is a common health problem in the adult population. Many risk factors including age, sex, prior eye surgery, various chronic diseases, and lifestyle factors can affect its development. We have evaluated the risk of dry eye syndrome based on the frequency of coffee consumption among Korean adult population.
Methods A total of 9,752 adults with age 19 years and older were randomly selected between 2010 and 2012. They have all participated in the National Health and Nutrition Examination Survey V of Korea. Dry eye syndrome was being diagnosed by the physicians at some points in the participant’s lifetime. The average daily coffee intake was divided into the following: less than 1 cup, 1 to 2 cups, and 3 cups or more. Various physio-environmental factors and medical conditions were used as correction variables to assess the risk of dry eye syndrome in relation to the frequency of coffee consumption.
Results The prevalence of dry eye syndrome decreased to 9.2%, 8.8%, and 6.3% as coffee consumption increased from less than 1 cup to 1–2 cups and more than 3 cups, respectively. However, there was no significant relationship between the frequency of coffee consumption and the risk of dry eye syndrome after adjusting various risk factors.
Conclusion There is no relationship between the frequency of coffee consumption and risk of dry eye syndrome.
Citations
Citations to this article as recorded by
The Relationship Between Caffeine Intake and Dry Eye Disease Morten Schjerven Magno, Tor P. Utheim, Mathias Kaurstad Morthen, Harold Snieder, Nomdo M. Jansonius, Christopher J. Hammond, Jelle Vehof Cornea.2023; 42(2): 186. CrossRef
TFOS Lifestyle: Impact of societal challenges on the ocular surface Fiona Stapleton, Juan Carlos Abad, Stefano Barabino, Anthea Burnett, Geetha Iyer, Kaevalin Lekhanont, Tianjing Li, Yang Liu, Alejandro Navas, Chukwuemeka Junior Obinwanne, Riaz Qureshi, Danial Roshandel, Afsun Sahin, Kendrick Shih, Anna Tichenor, Lyndon J The Ocular Surface.2023; 28: 165. CrossRef
TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface Anat Galor, Alexis Ceecee Britten-Jones, Yun Feng, Giulio Ferrari, David Goldblum, Preeya K. Gupta, Jesus Merayo-Lloves, Kyung-Sun Na, Shehzad A. Naroo, Kelly K. Nichols, Eduardo M. Rocha, Louis Tong, Michael T.M. Wang, Jennifer P. Craig The Ocular Surface.2023; 28: 262. CrossRef
TFOS Lifestyle: Impact of nutrition on the ocular surface Maria Markoulli, Sumayya Ahmad, Jayashree Arcot, Reiko Arita, Jose Benitez-del-Castillo, Barbara Caffery, Laura E. Downie, Katie Edwards, Judith Flanagan, Marc Labetoulle, Stuti L. Misra, Malgorzata Mrugacz, Sumeer Singh, John Sheppard, Jelle Vehof, Piera The Ocular Surface.2023; 29: 226. CrossRef
Modifiable lifestyle risk factors for dry eye disease Michael T.M. Wang, Alex Muntz, Brinda Mamidi, James S. Wolffsohn, Jennifer P. Craig Contact Lens and Anterior Eye.2021; 44(6): 101409. CrossRef
Background Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults.
Methods The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined.
Results Higher serum UA levels were associated with decreased levels of d-ROMs (P<0.05). The UA levels were positively associated with BAP levels (P<0.001).
Conclusion Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans.
Citations
Citations to this article as recorded by
Oxidative stress and type 2 diabetes: the development and the pathogenesis, Jordanian cross-sectional study Khalid M Abu Khadra, Mohammad Izzat. Bataineh, Ahmad Khalil, Jumana Saleh European Journal of Medical Research.2024;[Epub] CrossRef
The relationship between anemia and hyperuricemia and hypertension in Korean adults: the Korea National Health and Nutrition Examination Survey 2016–2018 Sang Muk Park, Mi Young Gi, Ju Ae Cha, Hyun Ho Sung, So Young Park, Cho Hee Park, Hyun Yoon Current Medical Research and Opinion.2023; 39(6): 819. CrossRef
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells Reyhane Ebrahimi, Parvin Pasalar, Hajar Shokri, Maryam Shabani, Solaleh Emamgholipour Journal of Physiology and Biochemistry.2022; 78(2): 343. CrossRef
Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS Ángela Hernández-Ruiz, Belén García-Villanova, Eduardo J. Guerra-Hernández, Cayetano Javier Carrión-García, Pilar Amiano, María-José Sánchez, Esther Molina-Montes Antioxidants.2022; 11(2): 300. CrossRef
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus Iuliia Azarova, Elena Klyosova, Alexey Polonikov European Journal of Clinical Investigation.2022;[Epub] CrossRef
Usefulness of routine blood test-driven clusters for predicting acute exacerbation in patients with asthma Ji Hyun Oh, Kyung-Min Ahn, Soo Jie Chung, Ji-Su Shim, Heung-Woo Park Respiratory Medicine.2020; 170: 106042. CrossRef
The Postprandial Effect of Anthocyanins on Cardiovascular Disease Risk Factors: a Systematic Literature Review of High-Fat Meal Challenge Studies Vinicius Andre do Rosario, Jaclyn Spencer, Katrina Weston-Green, Karen Charlton Current Nutrition Reports.2020; 9(4): 381. CrossRef
Nephrotoxic effects caused by co-exposure to noise and toluene in New Zealand white rabbits: A biochemical and histopathological study Amirreza Abouee-Mehrizi, Yahya Rasoulzadeh, Mehran Mesgari-Abbasi, Ahmad Mehdipour, Abbas Ebrahimi-Kalan Life Sciences.2020; 259: 118254. CrossRef
Association of sleep quality and sleep duration with serum uric acid levels in adults Yu-Tsung Chou, Chung-Hao Li, Wei-Chen Shen, Yi-Ching Yang, Feng-Hwa Lu, Jin-Shang Wu, Chih-Jen Chang, Xianwu Cheng PLOS ONE.2020; 15(9): e0239185. CrossRef
Background Early menarche may be associated with increased risk of cardiovascular disease. The aim of this study was to evaluate the relationship between age at menarche and metabolic syndrome (MetS) in Korean premenopausal women.
Methods We used nationally representative data from the Korea National Health and Nutrition Examination Survey from 2013 to 2014, and 3,023 premenopausal women aged 20–55 years were our subjects. We defined early menarche as age at first menstrual period less than 12 years. Multivariable logistic regression analysis was used to evaluate the relationship between age at menarche and MetS after adjusting for current age, and socioeconomic, lifestyle, and reproductive variables.
Results MetS was much more common in women aged 40–55 years than in women aged 20–39 years (4.1% vs. 15.1%). Compared with women who experienced menarche at age 12–15 years, the risk of MetS in the early menarche group was not higher in either age group, after adjusting for current age, and socioeconomic, lifestyle, and reproductive variables (odds ratio [OR], 1.767; 95% confidence interval [CI], 0.718–4.351 in those aged 20–39 years; OR, 1.780; 95% CI, 0.775–4.085 in those aged 40–55 years). The risk of MetS in women with menarche at age ≥16 years was not higher than in women with menarche at age 12–15 years.
Conclusion Early or late menarche was not associated with an increased risk of MetS in premenopausal Korean women. Even before menopause, current age has a major influence on the development of MetS.
Citations
Citations to this article as recorded by
Reproductive factors and metabolic syndrome among Chinese women aged 40 years and older Ling Bai, Xi Yang, Ziyi Sun, Zuojie Luo, Li Li, Xinghuan Liang, Jia Zhou, Liheng Meng, Yang Peng, Yingfen Qin Journal of Diabetes.2023; 15(1): 36. CrossRef
Separate and combined effects of famine exposure and menarche age on metabolic syndrome among the elderly: a cross-sectional study in China Congzhi Wang, Jiazhi Wang, Rui Wan, Ting Yuan, Liu Yang, Dongmei Zhang, Xiaoping Li, Haiyang Liu, Lin Zhang BMC Women's Health.2023;[Epub] CrossRef
Mediator or moderator? The role of obesity in the association between age at menarche and blood pressure in middle-aged and elderly Chinese: a population-based cross-sectional study Lin Zhang, Liu Yang, Congzhi Wang, Ting Yuan, Dongmei Zhang, Huanhuan Wei, Jing Li, Yunxiao Lei, Lu Sun, Xiaoping Li, Ying Hua, Hengying Che, Yuanzhen Li BMJ Open.2022; 12(5): e051486. CrossRef
Long-term health outcomes of early menarche in women: an umbrella review Jeong-Seon Lee, Young Ah Lee, Choong Ho Shin, Dong In Suh, Yun Jeong Lee, Dong Keon Yon QJM: An International Journal of Medicine.2022; 115(12): 837. CrossRef
Association between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case-Control Study Zahra Rahimi, Nader Saki, Bahman Cheraghian, Sara Sarvandian, Seyed Jalal Hashemi, Jamileh Kaabi, Amal Saki Malehi, Arman Shahriari, Nahal Nasehi Journal of Research in Health Sciences.2022; 22(3): e00558. CrossRef
Longitudinal 15-year follow-up of women with former early puberty: abnormal metabolic profiles not associated with earlier age at onset of puberty, but associated with obesity Somchit Jaruratanasirikul, Pitchaya Satitpatanapan, Hutcha Sriplung Journal of Pediatric Endocrinology and Metabolism.2021; 34(1): 71. CrossRef
The role of multiparity and maternal age at first pregnancy in the association between early menarche and metabolic syndrome among middle-aged and older women Tiago Novais Rocha, Pedro Rafael de Souza Macêdo, Afshin Vafaei, Dimitri Taurino Guedes, Ingrid Guerra Azevedo, Álvaro Campos Cavalcanti Maciel, Saionara Maria Aires da Câmara Menopause.2021; 28(9): 1004. CrossRef
Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females Shihui Fu, Ping Ping, Yulong Li, Bo Li, Yali Zhao, Yao Yao, Pei Zhang Journal of Translational Medicine.2021;[Epub] CrossRef
Letter to the Editor Regarding the Article: Relationship between Age at Menarche and Metabolic Syndrome in Premenopausal Women: Korea National Health and Nutrition Examination Survey 2013–2014 Anthony Urteaga, Miluska Robles, Alonso Soto Korean Journal of Family Medicine.2019; 40(4): 284. CrossRef
Age-Group Related Cohort Effects on the Association between Age at Menarche and Metabolic Syndrome among Korean Premenopausal Women Sunmi Yoo, Yun-Seo Hwang Korean Journal of Family Medicine.2019; 40(4): 280. CrossRef
Background This study aimed to investigate the relationship between marital status and the incidence of metabolic syndrome in Korean middle-aged women.
Methods Based on data from the sixth Korea National Health and Nutrition Examination Survey (2013–2014), 3,225 women aged 40–69 years were subjected to the analysis. Marital status was categorized as married, unmarried, separated, widowed, or divorced. The odds ratios (ORs) for metabolic syndrome were calculated based on marital status. After adjustment for age, income level, education level, alcohol intake, smoking status, leisure physical activity, menopause status, daily calories, and fat intake, changes in the OR for metabolic syndrome based on marital status were examined by multivariate logistic regression analysis.
Results The OR for metabolic syndrome in the widowed group to the married group was 4.818 (95% confidence interval [CI], 3.861–6.002; P<0.001) and that after adjustment of age, economic level, education level, alcohol intake, smoking status, physical activity, menopause status, total daily calories, and fat intake was 2.141 (CI, 1.432–3.199; P<0.001), both of which were statistically significant. The OR for metabolic syndrome in the unmarried group to the married group was 0.246 (CI, 0.141–0.431; P<0.001) after adjustment of all components. On the contrary, the ORs of the separated group and the divorced group to the married group were not significant.
Conclusion In comparison with the married middle-aged group, the widowed middle-aged group tended to have a higher risk of metabolic syndrome, which is speculated to be related to socioeconomic factors and health behavior.
Citations
Citations to this article as recorded by
Role of sex and gender-related variables in development of metabolic syndrome: A prospective cohort study Pouria Alipour, Zahra Azizi, Valeria Raparelli, Colleen M. Norris, Alexandra Kautzky-Willer, Karolina Kublickiene, Maria Trinidad Herrero, Khaled El Emam, Peter Vollenweider, Martin Preisig, Carole Clair, Louise Pilote European Journal of Internal Medicine.2024; 121: 63. CrossRef
Relationship between metabolic syndrome and depression: A study based on Rafsanjan Youth Cohort Study Mitra Abbasifard, Gholamreza Bazmandegan, Hamid Ostadebrahimi, Fatemeh Foroutanian, Zahra Kamiab Journal of Affective Disorders.2024; 361: 139. CrossRef
Exposure of cumulative atherogenic index of plasma and the development of prediabetes in middle-aged and elderly individuals: evidence from the CHARLS cohort study Yang Zou, Song Lu, Dongdong Li, Xin Huang, Chao Wang, Guobo Xie, Lihua Duan, Hongyi Yang Cardiovascular Diabetology.2024;[Epub] CrossRef
Metabolic syndrome prediction based on body composition indices Buthaina Alkhatib, Aliaa Orabi, Lana M. Agraib, Islam Al-Shami Journal of the Egyptian Public Health Association.2024;[Epub] CrossRef
Opium Use and the Risk of Cataract: a Hospital-based, Group-matched, Case–control Study in Iran Soheil Mehmandoost, Ali Sharifi, Hamid Reza Tohidinik, Shahriyar Shafa, Neda Hayati, Mohammad Sharifi, Willi McFarland, Hamid Sharifi Ophthalmic Epidemiology.2023; 30(1): 66. CrossRef
Level of Psychological and Somatic Symptoms Predict Perimenopausal Syndrome Severity Better Than Obstetric and Psychiatric History Do Among Korean Women Soyeon Kim, Sun Mi Kim, Da Seul Kim, Seunga Han, Ji Sun Hong, Jeong Seok Seo Psychiatry Investigation.2023; 20(1): 18. CrossRef
Prevalence and Determinants of Multiple Forms of Malnutrition among Adults with Different Body Mass Index: A Population‐Based Survey in the Philippines Wan-Chen Hsu, Aileen R. de Juras, Susan C. Hu, Sheba Mohankumar BioMed Research International.2023;[Epub] CrossRef
Prospective study on the association between serum unsaturated fatty acids and insulin resistance among workers Takako Miki, Sanmei Chen, Masafumi Eguchi, Takeshi Kochi, Ami Fukunaga, Akiko Nanri, Isamu Kabe, Tetsuya Mizoue Clinical Nutrition Open Science.2023; 49: 37. CrossRef
Metabolic Syndrome Among Human Immunodeficiency Virus Patients on Antiretroviral Therapy Attending Clinic at a District Hospital in Ghana Prince Osei Akumiah, Kwabena Opoku-Addai, Adwoa Safowaa, Akosua Serwaa Akumiah SN Comprehensive Clinical Medicine.2023;[Epub] CrossRef
Association between Menopause, Postmenopausal Hormone Therapy and Metabolic Syndrome Ying-Ju Ou, Jia-In Lee, Shu-Pin Huang, Szu-Chia Chen, Jiun-Hung Geng, Chia-Hung Su Journal of Clinical Medicine.2023; 12(13): 4435. CrossRef
Exploring the national prevalence of mental health risk, multimorbidity and the associations thereof: a repeated cross-sectional panel study Ashleigh Craig, Witness Mapanga, Asanda Mtintsilana, Siphiwe Dlamini, Shane Norris Frontiers in Public Health.2023;[Epub] CrossRef
The Effectiveness of Implementation of Healthy Living Community Movement in Overcoming Metabolic Syndrome Among Female Workers in East Kalimantan, Indonesia Farida Nailufar, Ali Khomsan, Yayuk Farida Baliwati, Hadi Riyadi Current Research in Nutrition and Food Science Journal.2022; 10(3): 1222. CrossRef
The Double Burden of Malnutrition at the Individual Level Among Adults: A Nationwide Survey in the Philippines Aileen R. de Juras, Wan-Chen Hsu, Susan C. Hu Frontiers in Nutrition.2021;[Epub] CrossRef
Metabolic syndrome and associated factors among severely ill psychiatric and non-psychiatric patients: a comparative cross-sectional study in Eastern Ethiopia Dilnessa Fentie, Tariku Derese, Bekele Yazie, Yibeltal Getachew Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef
Prevalence and associated factors of metabolic syndrome in Chinese middle-aged and elderly population: a national cross-sectional study Yang Xiong, Yangchang Zhang, Fuxun Zhang, Changjing Wu, Feng Qin, Jiuhong Yuan The Aging Male.2021; 24(1): 148. CrossRef
Gender Differences in the Pattern of Socio-Demographics Relevant to Metabolic Syndrome Among Kenyan Adults with Central Obesity at a Mission Hospital in Nairobi, Kenya Okubatsion Tekeste Okube, Samuel T. Kimani, Waithira Mirie High Blood Pressure & Cardiovascular Prevention.2020; 27(1): 61. CrossRef
Gender discrepancy of incidence and risk factors of metabolic syndrome among rural Chinese from 2012–2013 to 2015–2017 Shasha Yu, Xiaofan Guo, GuangXiao Li, Hongmei Yang, Guozhe Sun, Liqiang Zheng, Yingxian Sun Diabetology & Metabolic Syndrome.2020;[Epub] CrossRef
The burden of metabolic syndrome in patients living with HIV/AIDS receiving care at referral hospitals of Northwest Ethiopia: A hospital-based cross-sectional study, 2019 Alemu Gebrie Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(5): 1551. CrossRef
Background Diabetes mellitus is a global public health problem that is caused by the lack of insulin secretion (type 1) or resistance to its action (type 2). A low insulin-to-glucagon ratio predicts an increase in the serum levels of branched chain amino acids, a feature confirmed in several populations. This relationship has not been assessed in Jordan. The objective of this study was to investigate the association between serum branched chain amino acids and type 2 diabetes mellitus in patients in Jordan.
Methods Two hundred type 2 diabetes mellitus patients and an additional 200 non-diabetic controls were recruited. Age, body mass index, and waist circumference of the subjects were recorded. Branched chain amino acid, total cholesterol, and triglyceride levels were measured from the collected serum samples.
Results Serum branched chain amino acid levels were significantly higher in type 2 diabetes mellitus patients than in non-diabetes individuals (P<0.0001). In binomial regression analysis, serum branched chain amino acid levels remained significantly associated with diabetes mellitus and increased its risk (odds ratio, 1.004; 95% confidence interval, 1.001–1.006; P=0.003).
Conclusion Type 2 diabetes mellitus is associated with higher branched chain amino acid levels in Jordan independent of age, sex, body mass index, waist circumference, and total serum cholesterol and serum triglyceride levels.
Citations
Citations to this article as recorded by
Higher Levels of Serum Leptin Are Linked with a Reduction in Gait Stability: A Sex-Based Association Mahmoud A. Alfaqih, Ebaa Ababneh, Yousef Khader, Khawla Mhedat, Mai Sater Biomolecules.2025; 15(2): 195. CrossRef
Leptin and the rs2167270 Polymorphism Are Associated with Glycemic Control in Type Two Diabetes Mellitus Patients on Metformin Therapy Mahmoud A. Alfaqih, Mukhallad Aljanabi, Ebaa Ababneh, Mariam Khanfar, Mohammad Alqudah, Mai Sater Medicina.2023; 59(5): 997. CrossRef
Normalization of Vitamin D Serum Levels in Patients with Type Two Diabetes Mellitus Reduces Levels of Branched Chain Amino Acids Mahmoud A. Alfaqih, Nebras Y. Melhem, Omar F. Khabour, Ahmed Al-Dwairi, Lina Elsalem, Tasnim G. Alsaqer, Mohammed Z. Allouh Medicina.2022; 58(9): 1267. CrossRef
Dietary Management of Type 2 Diabetes in the MENA Region: A Review of the Evidence Nahla Hwalla, Zeinab Jaafar, Sally Sawaya Nutrients.2021; 13(4): 1060. CrossRef
Health Impact and Therapeutic Manipulation of the Gut Microbiome Eric Banan-Mwine Daliri, Fred Kwame Ofosu, Ramachandran Chelliah, Byong Hoon Lee, Deog-Hwan Oh High-Throughput.2020; 9(3): 17. CrossRef
Association of Circulating Branched-Chain Amino Acids with Gestational Diabetes Mellitus: A Meta-Analysis Liang Zhao, Meng Wang, Jun Li, Ye Bi, Minglong Li, Jie Yang International Journal of Endocrinology and Metabolism.2019;[Epub] CrossRef
Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan Mahmoud A. Alfaqih, Faheem Al-Mughales, Othman Al-Shboul, Mohammad Al Qudah, Yousef S. Khader, Muhammad Al-Jarrah Biomolecules.2018; 8(4): 117. CrossRef
The management of prolonged fever in low-socioeconomic-status areas by primary care providers such as general practitioners is challenging. Given the endemic nature of many infectious diseases, physicians typically start empirical antibiotic therapy following a limited diagnostic workup including serologic examinations. Herein, we report the case of a young male patient with prolonged fever and arthralgia initially diagnosed with and treated for brucellosis but with a confirmed diagnosis of systemic lupus erythematosus on follow-up. This unique case shows that close follow-up is the best practice for managing prolonged fever in cases with non-specific laboratory findings.
First
Prev
