Psoriasis is a chronic, autoimmune, and inflammatory disease that affects 2% of the world’s population. In recent years, it has been demonstrated that psoriasis confers a 25% increase in relative risk of cardiovascular disease, independent of factors such as hyperlipidemia, smoking, and obesity. The objective of this review was to analyze and describe the association between psoriasis and cardiovascular disease. In this review, we describe the epidemiological association of psoriasis and cardiovascular disease, pathophysiology, mechanisms, and its association with the well-known cardiovascular risk calculators. In addition, we describe diagnostic tools, such as imaging techniques and novel biomarkers, that are useful in the evaluation of atherosclerotic cardiovascular disease. Finally, we present different systemic therapies that are used in patients with psoriasis and their effect on atherosclerotic cardiovascular disease. This article provides an overview of the current literature on psoriasis and cardiovascular risk, which can be useful for primary care physicians in their daily clinical practice.

Citations

• Cardiovascular risk in patients with a relationship with oxidative stress and dyslipidemia
  Vesna Karanikolic, Mirjana Bakic, Sanja Gluscevic, Filiz Mercantepe, Aleksandra Klisic
  Journal of Medical Biochemistry.2025; 44(3): 614.     CrossRef
• Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence
  Rachel Sally, Camille Robinson, Seth J. Orlow, Jerry Shapiro, Michael Garshick, Kristen Lo Sicco
  JEADV Clinical Practice.2024; 3(1): 7.     CrossRef
• Automated mass screening and association rules analysis for comorbidities of psoriasis: A population‐based case–control study
  Bo Ri Kim, Kun Hee Lee, Kyungho Paik, Minjae Kim, Jung Min Bae, Chong Won Choi, Sang Woong Youn
  The Journal of Dermatology.2024; 51(4): 539.     CrossRef
• The impact of serum uric acid on psoriasis: NHANES 2005–2014 and Mendelian randomization
  Minghui Hu, Yangyang Wang, Wenwu Xu, Juan Bai, Xingming Tang
  Frontiers in Genetics.2024;[Epub]     CrossRef
• SCORE2 Screening Tool for Cardiovascular Risk Assessment in Psoriasis—A Case–Control Study
  Tomáš Kampe, Janette Baloghová, Peter Kolarčik, Kvetoslava Rimárová, Erik Dorko
  Journal of Clinical Medicine.2024; 13(11): 3237.     CrossRef
• Bilateral STA-MCA bypass for Moyamoya angiopathy associated with severe erythrodermic psoriasis
  Rohan Jha, Ari D. Kappel, Abdullah H. Feroze, Walid Ibn Essayed, Nirav J. Patel
  Journal of Stroke and Cerebrovascular Diseases.2024; 33(11): 107997.     CrossRef
• Jordanian Population’s Perception and Understanding of Psoriasis: A Cross-Sectional Study
  Rand Murshidi, Nour Shewaikani, Assem Al Refaei, Dana Q Khateeb, Raghad Al-Shami, Bayan E Hwidi, Maram Nasrallah, Leen Alshamasneh, Raghad Murshidi, Mahmoud Abdallat
  Cureus.2024;[Epub]     CrossRef
• The Impact of Treatment with IL-17/IL-23 Inhibitors on Subclinical Atherosclerosis in Patients with Plaque Psoriasis and/or Psoriatic Arthritis: A Systematic Review
  Aikaterini Tsiogka, Stamatios Gregoriou, Alexander Stratigos, Stergios Soulaidopoulos, Natalia Rompoti, Pantelis Panagakis, Marina Papoutsaki, Panagiotis Kostakis, George Kontochristopoulos, Konstantinos Tsioufis, Anna Campanati, Annamaria Offidani, Chara
  Biomedicines.2023; 11(2): 318.     CrossRef
• Association between cardio‐cerebrovascular disease and systemic antipsoriatic therapy in psoriasis patients using population‐based data: A nested case–control study
  Bo Ri Kim, Kun Hee Lee, Jinseob Kim, Jee Woo Kim, Kyungho Paik, Woojae Myung, Hyewon Lee, Chong Won Choi, Sang Woong Youn
  The Journal of Dermatology.2023; 50(11): 1442.     CrossRef
• Effect of psoriasis on cardiovascular risk
  Olga A. Kuzmina, Olga Iu. Mironova, Anfisa A. Lepekhova, Karinat S. Tregub, Artem I. Demin, Victor V. Fomin, Olga Yu. Olisova
  Russian Journal of Skin and Venereal Diseases.2023; 26(5): 465.     CrossRef
• Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data
  Anna Baran, Paulina Kiluk, Julia Nowowiejska, Tomasz W. Kaminski, Magdalena Maciaszek, Iwona Flisiak
  Biology.2022; 11(1): 88.     CrossRef
• Looking beyond the Skin: Pathophysiology of Cardiovascular Comorbidity in Psoriasis and the Protective Role of Biologics
  Isabel Andújar, Juan V. Esplugues, Patricia García-Martínez
  Pharmaceuticals.2022; 15(9): 1101.     CrossRef
• L-Theanine Alleviates IMQ-Induced Psoriasis Like Skin Inflammation by Downregulating the Production of IL-23 and Chemokines
  Yaohan Xu, Jiang Zhu, Jingyi Hu, Ziqi Zou, Yueling Zhao, Lihua Lai, Ping Xu, Yinjing Song, Hao Cheng
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets
  Yong Liu, Shengnan Cui, Jiayi Sun, Xiaoning Yan, Dongran Han
  Frontiers in Genetics.2021;[Epub]     CrossRef
• Cardiovascular comorbidities in psoriasis (Review)
  Daciana Branisteanu, Alin Nicolescu, Daniel Branisteanu, Catalina Branisteanu, Andreea Dragoi, Camelia Bogdanici, Mihaela Toader, Andreea Tucaliuc, Andreea Dimitriu, Doru Daogaru, Ruxandra Pirvulescu, Elena Porumb
  Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef

Background
High levels burden of long-term care of patients with schizophrenia can disrupt the functioning of family caregivers. This study evaluated a peer-assisted education method on family caregivers’ functioning of patients with schizophrenia.
Methods
In this randomized controlled trial, 64 family caregivers of schizophrenia patients in military hospitals of Tehran, Iran, were selected and randomly allocated to intervention and control groups, in 2018–2019. The peer-assisted education was performed in the experimental group for six 1-hour sessions and the family functioning was measured in both groups by the Family Assessment Device Scale. The data were analyzed by SPSS software ver. 16.0 (SPSS Inc., Chicago, IL, USA) and group differences at a level of P-value <0.05 were considered as significant.
Results
There was no significant differences between groups in the pre-intervention phase in all dimensions of family functioning (P>0.05). There were significant differences between intervention and control groups, in the post-intervention phase in mean problem-solving dimension (11.80 vs. 15.53, P=0.012) and in 2 weeks after intervention, in the dimensions of roles (21.71 vs. 23.43, P=0.015), affective involvement (19.03 vs. 21.59, P=0.017), behavior control (23.90 vs. 26.93, P=0.045), general functioning (27.15 vs. 31.40, P=0.013), and total family functioning (134.12 vs. 153.09, P=0.001).
Conclusion
The peer-assisted education significantly influenced the functioning of family caregivers of schizophrenic patients and can be recommended to improve the functioning of caregivers.

Citations

• Strategies to Alleviate the Burden Experienced by Informal Caregivers of Persons With Severe Mental Disorders in Low- and Middle-Income Countries: Scoping Review
  Olindah Silaule, Daleen Casteleijn, Fasloen Adams, Nokuthula Gloria Nkosi
  Interactive Journal of Medical Research.2024; 13: e48587.     CrossRef
• Family-based interventions versus standard care for people with schizophrenia
  Wai Tong Chien, Dennis Chak Fai Ma, Daniel Bressington, Huanyu Mou
  Cochrane Database of Systematic Reviews.2024;[Epub]     CrossRef
• Peer Support Activities for Veterans, Serving Members, and Their Families: Results of a Scoping Review
  Jean-Michel Mercier, Fardous Hosseiny, Sara Rodrigues, Anthony Friio, Suzette Brémault-Phillips, Duncan Shields, Gabrielle Dupuis
  International Journal of Environmental Research and Public Health.2023; 20(4): 3628.     CrossRef
• Effectiveness of family interventions for patients with schizophrenia: A systematic review and meta‐analysis
  Sin‐Hyang Kim, Sihyun Park
  International Journal of Mental Health Nursing.2023; 32(6): 1598.     CrossRef
• La pair-aidance pour soutenir le rétablissement en intervention précoce pour la psychose : enjeux autour de son implantation au Québec et dans la francophonie
  Paula Pires de Oliveira Padilha, Geneviève Gagné, Srividya N. Iyer, Esther Thibeault, Mary Anne Levasseur, Hélène Massicotte, Amal Abdel-Baki
  Santé mentale au Québec.2023; 48(1): 167.     CrossRef
• Primary-level and community worker interventions for the prevention of mental disorders and the promotion of well-being in low- and middle-income countries
  Marianna Purgato, Eleonora Prina, Caterina Ceccarelli, Camilla Cadorin, Jibril O Abdulmalik, Francesco Amaddeo, Lyria Arcari, Rachel Churchill, Mark JD Jordans, Crick Lund, Davide Papola, Eleonora Uphoff, Nadja van Ginneken, Wietse Anton Tol, Corrado Barb
  Cochrane Database of Systematic Reviews.2023;[Epub]     CrossRef
• Public Health Intervention for Smoking Cessation
  Soo Young Kim
  Korean Journal of Family Medicine.2021; 42(5): 343.     CrossRef

Background
Tobacco smoking is associated with several diseases and deaths in older Koreans. This study aimed to evaluate the factors associated with smoking cessation in older Koreans.
Methods
We selected 579 subjects who started smoking before the age of 65 years from the Korea National Health and Nutrition Examination Survey 2016–2018. We excluded the subjects who quit smoking before the age of 65 years, and then categorized the rest of subjects into those who stopped smoking after the age of 65 years and those who are constant smokers. Multivariable logistic analysis was performed to evaluate the factors related to smoking cessation among older Koreans.
Results
Among the participants, 66.1% were persistent smokers. After multivariable analysis, the factors significantly associated with smoking cessation were as follows: being in the age group of 75–79 years (adjusted odds ratio [aOR], 4.07; 95% confidence interval [CI], 2.12–7.83), being in the age group of 70–74 years (aOR, 3.10; 95% CI, 1.72–5.61), a family history of ischemic heart disease (aOR, 3.36; 95% CI, 1.09–10.35), and having had no cancer screening (aOR, 0.36; 95% CI, 0.18–0.70).
Conclusion
Further efforts to identify the factors related to smoking cessation will help formulate a smoking cessation policy.

Citations

• Current status of health promotion in Korea
  Soo Young Kim
  Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef

Background
Smoking is a preventable cause of chronic morbidity. Patient empowerment is a process through which people establish greater control over their health-related decisions and actions. To assess the effect of patient empowerment versus health education on the nicotine dependence score and progress of patients under different stages of smoking cessation.
Methods
This was a single-blinded randomized controlled clinical trial that included 76 smokers attending family medicine clinics. Participants were divided into two groups: empowerment and health education groups. Their nicotine-dependence score and smoking cessation stage were identified. All study participants were subjected to five health education sessions with a 3-month follow-up period.
Results
The mean nicotine-dependence score decreased significantly in both groups after the intervention. This decrease was slightly higher in the empowerment group; however, the difference was not statistically significant. After the intervention, 16.7% of the health education and 30.0% of the empowerment group transitioned from stage 1 to stages 2–4 of smoking cessation, with the change being statistically significant only in the empowerment group. There was no statistically significant difference in the number of study participants who stopped smoking between the health education and empowerment groups.
Conclusion
Both the empowerment model and traditional health education have similar positive effects on decreasing the nicotine-dependence level. There was a significant improvement in the stage of change for patients under the empowerment model, although there was no statistically significant difference between the groups regarding the number of participants who stopped smoking.

Citations

• The independent and moderator role of communicative health literacy on health, health behaviour and health care utilisation: a population based cross-sectional study
  F. Vincze, F.E.A. Israel, R. Ádány, É. Bíró
  Public Health.2025; 245: 105794.     CrossRef
• Behavioral health care provider’s beliefs, confidence, and knowledge in treating cigarette smoking in relation to their use of the 5A’s intervention
  Midhat Z. Jafry, Jayda Martinez, Tzuan A. Chen, Maggie Britton, Isabel Martinez Leal, Anastasia Rogova, Bryce Kyburz, Teresa Williams, Mayuri Patel, Brian J. Carter, Lorraine R. Reitzel
  Addictive Behaviors Reports.2023; 17: 100493.     CrossRef
• Developing Smoking Cessation Program for Female Smokers and Assessment of Its Impacts
  Kyung Hyun Suh
  STRESS.2023; 31(4): 189.     CrossRef
• Current status of health promotion in Korea
  Soo Young Kim
  Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef
• Public Health Intervention for Smoking Cessation
  Soo Young Kim
  Korean Journal of Family Medicine.2021; 42(5): 343.     CrossRef

Background
The ultrasonic stadiometer was originally developed as a device to measure and monitor children’s height. However, an ultrasonic stadiometer (InLab S50; InBody Co., Seoul, Korea) was used to measure adults’ height in the 2018 Korea Community Health Survey (KCHS). This study was conducted to assess the reliability and validity of the InLab S50 in adults.
Methods
The study subjects were 120 adults (reliability test, n=20; validity test, n=100) who had visited a health screening center. The intra- and inter-rater reliabilities of InLab S50 were assessed using the intraclass correlation coefficient (ICC). The agreement between InLab S50 and an automatic stadiometer (HM-201; Fanics, Busan, Korea) was assessed using Pearson’s correlation coefficient and Bland-Altman analysis.
Results
The intra- and inter-rater reliabilities of the InLab S50 were excellent (ICC=0.9999 and 0.9998, respectively). The correlation coefficient of the height measured by the two measurement devices was very high (r=0.996). The difference (Δheight [HM-201-InLab S50]) was -0.15±0.78 cm (95% limit of agreement [LOA], -1.69 to 1.38). After excluding the values outside 95% LOA, the difference was further reduced to -0.05±0.59 cm (95% LOA, -1.20 to 1.10).
Conclusion
This study showed that the InLab S50 is a reliable and valid device for the measurement of adults’ height. Therefore, we think that InLab S50 could be used to measure adults’ height in household health surveys such as the KCHS.

Citations

• Validation of portable ultrasonic stadiometers in adults
  Joaquim Huaina Cintra-Andrade, João Victor Alves Martins, Maria Izabel Freire-Correia, Mirele Savegnago Mialich Grecco, Matheus Lima Caetano, Lívia Zulmyra Cintra-Andrade, Wagner Luis Ripka
  Clinical Nutrition ESPEN.2025; 68: 8.     CrossRef
• Contactless Body Measurement System Using Single Fixed-Point RGBD Camera Based on Pose Graph Reconstruction
  Riu Cherdchusakulchai, Sucharn Thoumrungroje, Thanyaporn Tungpanjasil, Alongkorn Pimpin, Werayut Srituravanich, Nattapol Damrongplasit
  IEEE Access.2024; 12: 84363.     CrossRef
• Genetic Evidence of Endocannabinoid System on Perceived Stress and Restricted Food Intake: The Role of Variants rs324420 in FAAH Gene and rs1049353 in CNR1 Gene
  Tania Yadira Martínez-Rodríguez, Elia H. Valdés-Miramontes, José Francisco Muñoz-Valle, Zyanya Reyes-Castillo
  Cannabis and Cannabinoid Research.2024;[Epub]     CrossRef
• Association Between Perceived Noise Pollution and Sleep Quality: Findings from the 2018 Community Health Survey
  Sujin Lee, Jae Ho Chung
  Noise and Health.2024; 26(122): 346.     CrossRef
• Comparing the accuracy of an ultrasound height measurement device with a wooden measurement board among children aged 2–5 years in rural Lao People’s Democratic Republic: A methods-comparison study
  Shan Huang, Joel Conkle, Caroline S. E. Homer, Sengchanh Kounnavong, Khampheng Phongluxa, Joshua P. Vogel, Sayedur Rahman
  PLOS ONE.2023; 18(11): e0289514.     CrossRef
• Differences in accuracy of height, weight, and body mass index between self-reported and measured using the 2018 Korea Community Health Survey data
  Yoonsil Ko, Sunhye Choi, Jisoo Won, Yeon-Kyeng Lee, Dong-Hyun Kim, Seon Kui Lee
  Epidemiology and Health.2022; 44: e2022024.     CrossRef

Background
This study aimed to explore the relationship between fruit intake, changes in fruit intake, and changes in cardiometabolic factors in people with obesity.
Methods
A total of 21,270 subjects (8,718 men, 12,552 women) aged 40 years and over, from the Korean-based Genome and Epidemiology Study, were followed up for an average of 4.4 years. Fruit intake was assessed using a food frequency questionnaire at baseline and the second follow-up. The beta coefficient and confidence intervals for changes in cardiometabolic risk factors according to fruit consumption were calculated using a linear regression model.
Results
In men, the abdominal circumference decreased with changes in fruit intake (P=0.029). Fruit intake and increased fruit intake in men were associated with a lower systolic blood pressure (P=0.012 and P=0.02, respectively) and lower triglyceride levels (P=0.002 and P<0.001, respectively). In women, abdominal circumference decreased with both fruit intake and increased fruit intake (P<0.001 and P=0.013, respectively). Systolic blood pressure and triglycerides tended to decrease only with fruit intake (P=0.048 and P<0.001, respectively). Unlike in men, fasting blood glucose tended to decrease in women with both fruit intake and increased fruit intake (P=0.011 and P=0.005, respectively).
Conclusion
Fruit intake and increased fruit intake may have beneficial effects on cardiometabolic risk factors among individuals who are obese.

Citations

• Associations of cMIND Diet with depressive and anxiety symptoms among old people in China: a nationwide study
  Tengfei Niu, Yu Zhang, Xilin Zhou, Kun Shen, Xinyan Ji, Juan Zhu, Ouxiang Wu, Xiaobing Xian
  European Journal of Nutrition.2025;[Epub]     CrossRef
• Fruits and the Risk of Type 2 Diabetes: The Korean Genome and Epidemiology Study Cohort
  Hojun Yu, Cheol Min Lee, Seung-Won Oh
  Korean Journal of Family Medicine.2024; 45(1): 44.     CrossRef
• Association between cMIND diet and hypertension among older adults in China: a nationwide survey
  Yazhu Wang, Yu Zhang, Xinrong Zeng, Xiaobing Xian, Jingyu Chen, Tengfei Niu
  Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
• Impact of fruits and vegetables consumption on metabolic health: a case–control study
  Azza Abd El-Shaheed, Nermine N. Mahfouz, May M. Abdel Hamid
  Bulletin of the National Research Centre.2024;[Epub]     CrossRef
• Effects of Semaglutide on Cardiac Protein Expression and Cardiac Function of Obese Mice
  Xiaoyu Pan, Lin Yue, Jiangli Ban, Lin Ren, Shuchun Chen
  Journal of Inflammation Research.2022; Volume 15: 6409.     CrossRef
• Current status of nutrient intake in Korea: focused on macronutrients
  Seung-Won Oh
  Journal of the Korean Medical Association.2022; 65(12): 801.     CrossRef
• Current status of health promotion in Korea
  Soo Young Kim
  Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef

Background
The aim of this study was to evaluate the association between near work time and depression.
Methods
Data of 1,551 workers aged 19–49 years from the sixth Korea National Health and Nutrition Examination Survey were examined. The Patient Health Questionaire-9 scores were used to screen for depression. Participants who scored a total of 10 or above, which is suggestive of the presence of depression, were classified as the depression group; the rest were classified as normal. The correlation between daily near work time and depression was analyzed using multivariate logistic analysis after adjusting for other sociodemographic and health behavior-related variables.
Results
Multivariate logistic analysis found that workers with 3 or more hours of near work were more likely to report depression compared to the reference group who had 2 or fewer hours per day of near work (adjusted odds ratio, 2.471; 95% confidence interval, 1.062–5.747).
Conclusion
Longer near work time was associated with depression among South Korea’s workers. Therefore, it is necessary to reduce near work time to prevent depression.

Citations

• Low Vision Rehabilitation and Eye Exercises: A Comprehensive Guide to Tertiary Prevention of Diabetic Retinopathy
  Tibor Rák, Andrea Kovács-Valasek, Etelka Pöstyéni, Róbert Gábriel, Adrienne Csutak
  Life.2025; 15(6): 857.     CrossRef

Background
It is a well-known fact that exclusive breastfeeding benefits both mothers and their babies. The aim of this study is to assess the associated factors influencing exclusive breastfeeding of babies until 6 months of age.
Methods
The study used data from the 2017 Indonesia Demographic and Health Survey. Overall, 1,542 women who had infants aged below 6 months were included in the study. Sociodemographic and maternal health service utilization factors were examined for association with exclusive breastfeeding, using logistic regression for a complex sample design.
Results
The proportion of exclusive breastfeeding was 52.3% (95% confidence interval [CI], 0.498–0.548). Parity, antenatal care visits, early initiation of breastfeeding, low-income households, and rural areas were significant factors associated with the increased likelihood of exclusive breastfeeding. However, working status (adjusted odds ratio [aOR], 0.70; 95% CI, 0.57–0.86) and caesarean delivery or C-section (aOR, 0.75; 95% CI, 0.57–0.99) were factors for a lower likelihood of exclusive breastfeeding.
Conclusion
Working women are at risk of discontinuation of exclusive breastfeeding. Mothers who had a normal vaginal delivery and practiced early initiation of breastfeeding had a higher rate of exclusive breastfeeding. These findings have important implications for developing comprehensive guidance and resources for women regarding the importance of exclusive breastfeeding during the early postpartum period.

Citations

• Correlations between family characteristics and childcare in optimizing the growth of children under six years
  Laili Rahayuwati, Desy Indra Yani, Sri Hendrawati, Arlette Suzy Setiawan, Damar Irza, Sherllina Rizqi Fauziah
  BMC Public Health.2025;[Epub]     CrossRef
• Economic and environmental impacts of commercial milk formula in Indonesia: estimates and comparisons using the Cost of Not Breastfeeding, Green Feeding, and Mothers’ Milk Tools
  Nabila Nur Septiani, Andini Pramono, Tuan Thanh Nguyen, Roger Mathisen, Julie Smith
  International Breastfeeding Journal.2025;[Epub]     CrossRef
• Educational Packages on Breastfeeding Increase Behavior and Self-Efficacy of Mothers
  Stefi Maizuputri, Muthia Mutmainnah, Meinarisa
  Jurnal Berita Ilmu Keperawatan.2024; 17(2): 152.     CrossRef
• Role of proper postnatal care in continued exclusive breastfeeding among young Indonesian mothers
  Wahyu Triadmajani, Shinta Prawitasari, Abdul Wahab
  Clinical and Experimental Pediatrics.2024; 67(12): 686.     CrossRef
• Does caesarean section have an impact on exclusive breastfeeding? Evidence from four Southeast Asian countries
  Kyaw Lwin Show, Nampet Jampathong, Pyae Linn Aung, Kyawt Mon Win, Chetta Ngamjarus, Porjai Pattanittum, Thae Maung Maung, Khaing Nwe Tin, Su Mon Myat, Meghan A Bohren, Nogati Chairunnisa, Pisake Lumbiganon
  BMC Pregnancy and Childbirth.2024;[Epub]     CrossRef
• The practice of exclusive breastfeeding by region in Indonesia
  Haerawati Idris, Dea Widya Astari
  Public Health.2023; 217: 181.     CrossRef
• Social media utilization and knowledge levels in exclusive breastfeeding among mothers in Indonesia
  Deswani Deswani, Dea Eki Rahmawati, Yuli Mulyanti, Syafdewiyani Syafdewiyani, Rita Ismail, Sri Djuwitaningsih
  Healthcare in Low-resource Settings.2023;[Epub]     CrossRef
• Analysis of Supporting Factors Associated with Exclusive Breastfeeding Practice in the Urban Setting during the COVID-19 Pandemic
  Agrina Agrina, Dedi Afandi, Suyanto Suyanto, Erika Erika, Yulia Irvani Dewi, Siska Helina, Dita Pramita, Nanda Safira
  Children.2022; 9(7): 1074.     CrossRef

This case illustrates the medical complication of a child that arose as a consequence of parents with intellectual disabilities in a primary care setting. A 9-month-old girl presented with multiple admissions because of recurrent pneumonia and was later diagnosed with failure to thrive based on child neglect resulting from the parents’ disabilities. This exemplifies a failure to thrive case with a complex and undiagnosed psychosocial background that required interdepartmental involvement to mitigate the health problem.

Background
The diagnosis of food allergies needs to be confirmed through an oral food challenge (OFC). However, specific immunoglobulin E (sIgE) concentrations analyzed by serological tests are also helpful in determining OFC items and predicting the presence of allergic reactions. Unfortunately, there is a limit to the number of antigens that can be simultaneously evaluated at one time. The purpose of this study was to analyze the possibility of detecting sIgE antibodies against food using clues in self-reported food allergy symptoms.
Methods
Medical records of 377 patients aged 3 years or younger were collected for egg white-, cow’s milk-, walnut- and soybean-sIgE sensitization, and related clinical history. Each clinical history was classified into class 1: direct-isolated intake resulting in anaphylaxis or hives with consistent clincical history; class 2a: class 1 with inconsistency; class 2b: indirect-mixed intake resulting in anaphylaxis or hives regardless of consistency; class 2c: direct/indirect-isolated/mixed intake resulting in itching without hives, vomiting, or diarrhea with consistent clincical history; or class 3: class 2c with inconsistency or asymptomatic to direct, isolated exposure.
Results
The area under the curve (AUC) of class 1 for cow’s milk was 0.790, and the accuracy was 78.0%. The AUC of class 1 and 2 for egg white was better than that of class 1 (0.750), and the accuracy rate was 77.6%. The AUCs of class 1 for walnut and soybean were 0.775 and 0.662, respectively.
Conclusion
In conclusion, sIgE sensitization to foods could be predicted by the combination of exposure and selfreported symptoms in children under 3 years of age.

Citations

• Oral Food Challenge in Children with Tree Nut and Peanut Allergy: The Predictive Value of Diagnostic Tests
  Ludovica Cela, Alessandro Gravina, Antonio Semeraro, Francesca Pastore, Rebecca Morelli, Lavinia Marchetti, Giulia Brindisi, Francesca Olivero, Maria Grazia Piccioni, Anna Maria Zicari, Caterina Anania
  Diagnostics.2024; 14(18): 2069.     CrossRef