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Volume 43(2); March 2022

Editorial

Severe Adverse Drug Reactions in Korean Elderly Patients
Jungun Lee
Korean J Fam Med 2022;43(2):91-92.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.43.2E
  • 3,123 View
  • 80 Download

Review Articles

Teaching Family Medicine and General Practice
Muhammad Jawad Hashim
Korean J Fam Med 2022;43(2):93-100.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.20.0223
The teaching of family medicine and general practice should aim to develop an appreciation of the unique nature and role of the specialty. Teachers should relate patient cases to the principles of family medicine. These principles include (1) compassionate care; (2) a generalist/holistic approach focusing on the whole person, family, and community; (3) continuity of relationship, i.e., building a patient-physician bond of trust; (4) reflective mindfulness; and (5) lifelong learning. The curriculum, instructional strategy, and assessment should be carefully aligned. Core competencies include patient-centered communication, physical examination skills, clinical procedures, palliative care, humanities in medicine, holistic care, shared decision-making, family therapy, home and community visits, chronic disease care, problem-based documentation, team-based care, data-driven improvement, information mastery, ethics and professionalism, and work-life balance. Family medicine/general practice is defined as the medical specialty that manages common and long-term illnesses, focusing on overall health and well-being. Hence, clerkship schedules should maximize clinical exposure and opportunities for self-reflection. A learner-centered approach should begin with a self-identified inventory of learning needs based on the curriculum; next, these needs should be chosen as topics for student presentations. Teaching methods should include mini-workshops: a combination of didactic lectures and small-group exercises. Individual face-to-face formative feedback should occur at midcourse and culminate in a group reflection on the learning experience. Clinical supervision should gradually decrease as each resident demonstrates safe patient care. Procedure skills training should be closely supervised, formally documented, and constitute about one-fourth of learning sessions.

Citations

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    Seung-Won Oh
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  • 4 Web of Science
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Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates
Rania Itani, Lama Soubra, Samar Karout, Deema Rahme, Lina Karout, Hani M J Khojah
Korean J Fam Med 2022;43(2):101-108.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.21.0103
Primary dysmenorrhea (PD) is a common, disregarded, underdiagnosed, and inadequately treated complaint of both young and adult females. It is characterized by painful cramps in the lower abdomen, which start shortly before or at the onset of menses and which could last for 3 days. In particular, PD negatively impacts the quality of life (QOL) of young females and is the main reason behind their absenteeism from school or work. It is suggested that increased intrauterine secretion of prostaglandins F2α and E2 are responsible for the pelvic pain associated with this disorder. Its associated symptoms are physical and/or psychological. Its physical symptoms include headache, lethargy, sleep disturbances, tender breasts, various body pains, disturbed appetite, nausea, vomiting, constipation or diarrhea, and increased urination, whereas its psychological symptoms include mood disturbances, such as anxiety, depression, and irritability. While its diagnosis is based on patients’ history, symptoms, and physical examination, its treatment aims to improve the QOL through the administration of nonsteroidal anti-inflammatory drugs, hormonal contraceptives, and/or the use of non-pharmacological aids (e.g., topical heat application and exercise). Patients must be monitored to measure their response to treatment, assess their adherence, observe potential side effects, and perform further investigations, if needed.

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    Gowhar Rashid, Nihad Ashraf Khan, Deena Elsori, Andleeb Rehman, Tanzeelah, Haleema Ahmad, Humaira Maryam, Amaan Rais, Mohd Salik Usmani, Asaad Ma Babker, Mohammad Azhar Kamal, Wael Hafez
    Frontiers in Medicine.2023;[Epub]     CrossRef
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    Rania Itani, Hani MJ Khojah, Samar Karout, Rana Abu-Farha, Tareq L. Mukattash, Deema Rahme, Khouloud Housary, Hiam El Achi, Ali O. Safar, Ismail Karam Al Hajj, Abdalla El-Lakany
    BMC Health Services Research.2023;[Epub]     CrossRef
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    Lauren J. Gray, Hannah Durand
    BMC Women's Health.2023;[Epub]     CrossRef
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    Healthcare.2023; 11(11): 1633.     CrossRef
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    Dhea Regita Sastika Putri, Budi Prasetyo, Annis Catur Adi, Anton Komaini, Novadri Ayubi
    Fizjoterapia Polska.2023; 23(5): 185.     CrossRef
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    International Journal of Complementary & Alternative Medicine.2023; 16(3): 138.     CrossRef
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    Amira Abdallah El-Houfey, Amany A. Ahmed, Shimaa Gamal Eldein Ibraheim, Wafaa Atta Mohammed
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    Roberta Francavilla, Maddalena Petraroli, Giulia Messina, Brigida Stanyevic, Arianna Maria Bellani, Susanna MR Esposito, Maria E. Street
    Clinical and Experimental Obstetrics & Gynecology.2023;[Epub]     CrossRef
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    Cureus.2022;[Epub]     CrossRef
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    Samar Karout, Lama Soubra, Deema Rahme, Lina Karout, Hani M J Khojah, Rania Itani
    BMC Women's Health.2021;[Epub]     CrossRef
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Original Articles

Is Ankle Kinesio Taping Effective to Immediately Change Balance, Range of Motion, and Muscle Strength in Healthy Individuals? A Randomized, Sham-Controlled Trial
Melda Soysal Tomruk, Murat Tomruk, Emrullah Alkan, Nihal Gelecek
Korean J Fam Med 2022;43(2):109-116.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.21.0015
Background
The ankle–foot complex plays a key role in maintaining balance because it collects proprioceptive data. Kinesio taping (KT) is a rehabilitative method performed by the cutaneous application of a special elastic tape. The mechanical correction technique of KT was suggested to reposition the joints and alter balance parameters. The aim was to reveal the pure effects of ankle KT on balance, range of motion (ROM), and muscle strength in healthy individuals.
Methods
Forty healthy students were recruited for this randomized, sham-controlled study at a local university. Participants were divided into two groups—experimental and sham application groups. The primary outcome measures were balance parameters. Athlete Single Leg (ASL), Limits of Stability (LoS), and Clinical Test of Sensory Interaction and Balance (CTSIB) were used to measure single-leg dynamic balance, dynamic postural control, and sensory interaction of balance, respectively. Dorsiflexion ROM and dorsiflexor muscle strength were the secondary outcomes.
Results
The ASL score showed significant improvement only in the experimental KT group (P=0.02); however, the LoS score increased significantly in both groups (P<0.05). CTSIB scores, dorsiflexion ROM, and dorsiflexor muscle strength for both ankles did not change in any of the groups after intervention (P>0.05). Moreover, there was no superiority of one intervention over the other in improving any of the variables (P>0.05).
Conclusion
The mechanical correction technique of KT can be useful in providing immediate improvement in single-leg dynamic balance in healthy individuals. However, it may not be effective to significantly change the sensory interaction of balance, dorsiflexion ROM, and muscle strength.

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    Jiaqi Lou, JiLiang Li, Youfen Fan, Chun Zhang, Neng Huang
    Pain Management Nursing.2024; 25(4): 377.     CrossRef
  • Acute effects of kinesiology taping on physical parameters and functional performance in handball players: a double-blinded, randomised placebo-controlled trial
    Eren Arabaci, Ertugrul Deniz Kose, Kubra Okuyucu
    Sport Sciences for Health.2024; 20(4): 1333.     CrossRef
  • Functional ankle taping correction on plantar foot ulcer healing in diabetic patients: Randomized controlled trial
    Ahmed Elfahl, Sobhy Aly, Heba Elfeky
    Physiotherapy Practice and Research.2024; : 1.     CrossRef
  • Immediate effects of elastic tape application on the foot sole: a randomized controlled trial
    Riyaka Ito, Tatsuya Igawa, Ryunosuke Urata, Shomaru Ito, Kosuke Suzuki, Marino Suzuki, Akira Kubo
    Journal of Physical Therapy Science.2023; 35(7): 497.     CrossRef
  • 4,137 View
  • 109 Download
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Exposure to Secondhand Smoke and a Tobacco-Specific Carcinogen in Non-Smokers
Jae-woo Lee, Woojung Yang, Ye-Seul Kim, Yonghwan Kim, Hyo-Sun Yoo, Hee-Taik Kang
Korean J Fam Med 2022;43(2):117-124.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.21.0073
Background
The International Agency for Research on Cancer classifies 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) as a known carcinogen. This study aimed to investigate the association between exposure to secondhand smoke (SHS) and NNAL concentrations in non-smokers.
Methods
This was a cross-sectional study based on data from the 2016 to 2018 Korea National Health and Nutrition Examination Survey. Urine NNAL concentrations were categorized into tertiles of 3,615 study participants who were non-smokers. All sampling and weight variables were stratified, and analyses to account for the complex sampling design were conducted.
Results
The overall, male, and female percentages of SHS exposure among non-smokers were 22.4%, 29.2%, and 20.4%, respectively. The geometric means of urine NNAL concentrations were 1.896±0.098 pg/mL and 1.094±0.028 pg/mL in the SHS exposure and non-exposure groups, respectively. After adjusting for confounding variables, in the total group, the geometric mean of urine NNAL concentrations was significantly higher in the SHS exposure group than in the SHS non-exposure group (adjusted P-value <0.001). Compared with the non-exposure group, the adjusted odds ratios (95% confidence intervals) for the highest NNAL tertile group of overall SHS exposure in the total, men, and women groups were 2.44 (1.95–3.05), 1.65 (1.08–2.53), and 2.73 (2.11–3.52), respectively, after full adjustment.
Conclusion
The urine NNAL concentration in the SHS exposure group was significantly higher than that in the non-exposure group. Exposure to SHS was associated with a higher risk of elevated urine NNAL concentrations in non-smokers.

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  • Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study
    S. Michael Ansari, Patrice Leroy, Guillaume de La Bourdonnaye, Sandrine Pouly, Lindsay Reese, Christelle Haziza
    Biomarkers.2025; 30(2): 178.     CrossRef
  • High throughput and sensitive quantitation of tobacco-specific alkaloids and nitrosamines in wastewater
    Zhe Wang, Qiuda Zheng, Benjamin J. Tscharke, Jinglong Li, Jake W. O'Brien, Brad Patterson, Zeyang Zhao, Kevin V. Thomas, Jochen F. Mueller, Phong K. Thai
    Talanta.2024; 277: 126401.     CrossRef
  • Association Between Second-Hand Smoke Exposure and Respiratory Symptoms Among the General Population of Non-smoker Adults in Saudi Arabia: A Cross-Sectional Study
    Mohammed Madkhali, Safa Shariff, Raghad Albalawi, Abdulrahman Aqeel, Abdulqader Alshahrani, Raghd Alabdullah, Raghad Alasmari, Wajd Aljohani
    Cureus.2023;[Epub]     CrossRef
  • Short-Term Effects of Side-Stream Smoke on Nerve Growth Factor and Its Receptors TrKA and p75NTR in a Group of Non-Smokers
    Anna Maria Stabile, Alessandra Pistilli, Desirée Bartolini, Eleonora Angelucci, Marco Dell’Omo, Gabriele Di Sante, Mario Rende
    International Journal of Environmental Research and Public Health.2022; 19(16): 10317.     CrossRef
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  • 133 Download
  • 4 Web of Science
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Risk Factors Related to Serious Adverse Drug Reactions Reported through Electronic Submission during Hospitalization in Elderly Patients
Seon-Hye Won, Sang-Yeon Suh, Eunji Yim, Hong-Yup Ahn
Korean J Fam Med 2022;43(2):125-131.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.21.0086
Background
Many studies have assessed the risk factors for adverse drug reactions (ADRs) in elderly patients. However, most of these studies have focused on risk factors for ADRs, not serious ADRs (s-ADRs). s-ADRs are commonly found in hospitalized patients. s-ADRs warrant imminent but thorough investigations, given their critical impact on patient health. Therefore, this retrospective study aimed to assess the associated risk factors for s-ADRs in elderly hospitalized patients.
Methods
In-patients aged >65 years having ADRs during hospitalization at a university hospital in Korea between 2010 and 2012 were included. Medical professionals spontaneously reported ADRs using an electronic submission system at the study hospital. Further, all descriptions of ADRs were characterized and categorized through the screening of electronic medical records. We compared the characteristics of patients having s-ADRs with those of patients not having s-ADRs.
Results
There were 353 cases of ADRs, 67 of which were s-ADRs. Patients taking more than eight concomitant drugs showed the highest odds ratio (OR, 11.99; 95% confidence interval [CI], 3.42–42.03). The ratio of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) was also significantly related to s-ADRs (OR, 2.78; 95% CI, 1.33–5.81). The use of antibiotics (OR, 2.39; 95% CI, 1.13–5.02) and antineoplastics (OR, 4.17; 95% CI, 1.09–15.94) were significant risk factors.
Conclusion
Our findings highlight the importance of polypharmacy. Liver function tests (AST/ALT ratio) must be monitored carefully within high-risk groups for ADRs.

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    Ran An, Dong‐Jie Sun, Hao‐Xue Lei, Ang‐Ran He, Ying Tu, Jun‐Ting Tang
    The Journal of Dermatology.2025; 52(1): 87.     CrossRef
  • Risk factors for severe adverse drug reactions in hospitalized patients
    Nemanja Z. Petrović, Ana V. Pejčić, Miloš N. Milosavljević, Slobodan M. Janković
    Open Medicine.2025;[Epub]     CrossRef
  • Drug-Induced Serious Cutaneous Reactions in Hospitalized Patients: A Cross-Sectional Study
    Warisara Jiamsathit, Kansuda Bunarong, Sonthiya Papenkort, Anthony R. Cox, Narumol Jarernsiripornkul
    Journal of Clinical Medicine.2025; 14(3): 857.     CrossRef
  • Epidemiology of reported serious adverse drug reactions due to anti-infectives using nationwide database of Thailand
    Sopit Sittiphan, Apiradee Lim, Haris Khurram, Nurin Dureh, Kwankamon Dittakan, Obed Kwabena Offe Amponsah
    PLOS ONE.2025; 20(2): e0318597.     CrossRef
  • Potential inappropriate medications and drug–drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database
    Huaqiao Jiang, Yanhua Lin, Weifang Ren, Lina Lu, Xiaofang Tan, Xiaoqun Lv, Ning Zhang
    Frontiers in Pharmacology.2025;[Epub]     CrossRef
  • Drug Related Problems among Older Inpatients at a Tertiary Care Setting
    Porrawee Pramotesiri, Krongtong Putthipokin, Sirasa Ruangritchankul
    Journal of Clinical Medicine.2024; 13(6): 1638.     CrossRef
  • Exploring the community pharmacist’s knowledge, attitude, and practices regarding adverse drug reactions and its reporting in the United Arab Emirates: a survey-based cross-sectional study
    Javedh Shareef, Sathvik Belagodu Sridhar, Mullaicharam Bhupathyraaj, Atiqulla Shariff, Sabin Thomas
    Therapeutic Advances in Drug Safety.2024;[Epub]     CrossRef
  • Severe Adverse Drug Reactions in Korean Elderly Patients
    Jungun Lee
    Korean Journal of Family Medicine.2022; 43(2): 91.     CrossRef
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  • 96 Download
  • 7 Web of Science
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Association between Complementary and Alternative Medicine Use and Fear of Cancer Recurrence among Breast Cancer Survivors
Esther Eun Hwa Kim, Jihun Kang
Korean J Fam Med 2022;43(2):132-140.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.20.0158
Background
This study aimed to evaluate the association between complementary and alternative medicine (CAM) use and fear of cancer recurrence (FCR) among breast cancer survivors, using a validated multidimensional FCR-assessing instrument. Despite the debate over its medical effects, the use of CAM in breast cancer survivors is increasing.
Methods
We recruited 326 breast cancer survivors who had completed the primary cancer treatment. Information on CAM use was obtained using a self-administered questionnaire, and FCR was assessed using the Korean version of the FCR Inventory (FCRI). Multivariate linear regression analysis was performed to evaluate the association between CAM use and FCR.
Results
CAM users had higher total FCR scores than CAM non-users after covariate adjustment (CAM users: 74.6 vs. CAM non-users: 68.7; P=0.047). Among the FCRI subscales, CAM users showed higher coping strategy scores (CAM users: 22.3 vs. CAM non-users: 20.6; P=0.034) in the multivariable adjusted analysis. The use of multiple types of CAM was associated with increased FCR in a dose-dependent manner (P=0.002).
Conclusion
Breast cancer survivors who used CAM had a higher FCR than CAM non-users. The dose-response relationship between the use of multiple types of CAM and FCR suggests that breast cancer survivors who use multiple types of CAM should be provided with appropriate psychological interventions to decrease FCR.

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  • Critical Considerations Regarding the Article “Association between Complementary and Alternative Medicine Use and Fear of Cancer Recurrence among Breast Cancer Survivors”
    Niloufar Johari Varnoosfaderani, Ehsan Amiri-Ardekani
    Korean Journal of Family Medicine.2023; 44(1): 66.     CrossRef
  • Use of complementary and alternative medicine for reducing fear of cancer recurrence among cancer survivors: Does it work?
    Heliang Wu, Adnan Rashid Aziz, Mahlagha Dehghan, Leyla Ahmadi Lari, Rasmieh Al-Amer, Mohammad Ali Zakeri
    Asia-Pacific Journal of Oncology Nursing.2023; 10(10): 100278.     CrossRef
  • Adherence to lifestyle recommendations among Norwegian cancer survivors and the impact of traditional and complementary medicine use: the Tromsø Study 2015–2016
    Kiwumulo Nakandi, Faith O. Benebo, Laila A. Hopstock, Trine Stub, Agnete E. Kristoffersen
    BMC Complementary Medicine and Therapies.2023;[Epub]     CrossRef
  • 4,210 View
  • 77 Download
  • 3 Web of Science
  • 3 Crossref
Cultural Adaption and Psychometric Analysis of Family APGAR Scale in Iranian Older People
Zeinab Karimi, Zahra Taheri-Kharameh, Fatemeh Sharififard
Korean J Fam Med 2022;43(2):141-146.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.21.0028
Background
Family function is a necessary factor that influences older people’s health. The Family APGAR has been widely used to study family functions. However, there has been no Persian version of this instrument to assess family function in older people. The aim of this study was to determine the psychometric properties of the Persian version of the Family APGAR Scale to evaluate the perception of family functions.
Methods
The “forward-backward” procedure was applied to translate the scale from English into Persian. The translated version was checked in terms of validity and reliability, with a sample of 281 older people selected from retirement centers. The factor structure of the scale was also tested using a confirmatory factor analysis. To test reliability, internal consistency and test–retest analyses were performed.
Results
The results of the confirmatory factor analysis indicated a good structural model. Criterion-related validity was strongly supported by the pattern of association between the APGAR Scale and the social support survey. Cronbach’s α of the scale was 0.88 and test–retest reliability ranged from 0.96 to 0.98, indicating a good range of reliability.
Conclusion
The findings of this study suggest that the Iranian version of the Family APGAR is a valid and reliable scale to evaluate family functions in health intervention programs.

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    Journal of Clinical Medicine.2025; 14(2): 617.     CrossRef
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    Jinping Li, Yan Wang, Minfeng Zhai, Mengyuan Qin, Dandi Zhao, Qian Xiang, Zaoyuan Shao, Panrong Wang, Yan Lin, Yiting Dong, Yan Liu
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  • Psychometric adequacy of the persian adapted version of the tilburg frailty indicator (P-TFI)
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Case Reports
A Rare Case of Spinal Epidural Abscess Following Urinary Tract Infection Caused by Escherichia coli in a Patient with Pre-existing Stress Fractures of the Lumbar Spine
Wooram Shin, Ju Hwan Oh, A Young Cho, In Sup Song, Young Suk Kim, Kwang Young Lee, In O Sun
Korean J Fam Med 2022;43(2):147-149.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.20.0226
Spinal epidural abscess (SEA) caused by Escherichia coli is an uncommon condition. It usually occurs secondary to urinary tract infection (UTI), following hematogenous propagation. Disruption of spinal anatomic barriers increases susceptibility to SEA. Although rarely, such disruption can take the form of lumbar spine stress fractures, which can result from even innocuous activity. Here, we describe a case of SEA secondary to UTI in a patient with pre-existing stress fractures of the lumbar spine, following use of an automated massage chair. Successful treatment of SEA consisted of surgical debridement and a six-month course of antibiotic therapy.

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A Case Report of Male Systemic Lupus Erythematous with Antinuclear Antibodies-Negative: A Challenging Diagnosis
Ruziana Baharudin, Nur Suhaila Idris, Juliawati Muhammad, Wan Noor Hasbee Wan Abdullah
Korean J Fam Med 2022;43(2):150-154.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.20.0211
Systemic lupus erythematosus (SLE) is a connective tissue disease of unknown etiology that predominantly affects women of childbearing age. We report a case of male systemic lupus erythematous with antinuclear antibodies and typical clinical presentations of multiple skin lesions, polyarticular joint pain, fatigue, anorexia, and hair loss. Full evaluations were used to establish a diagnosis of SLE. The lower prevalence of SLE among males and antinuclear antibody-negative patients poses a great challenge for diagnosis. Therefore, as primary care doctors, we need to have a high suspicion of systemic lupus erythematous even in male and antinuclear antibody-negative patients. Thus, early treatment may help patients improve their quality of life.

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    Qaisar Ali Khan, Tehmina khan, Parsa Abdi, Christopher Farkouh, Michelle Anthony, Faiza Amatul Hadi, Sumaira Iram
    Clinical Medicine Insights: Case Reports.2023;[Epub]     CrossRef
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