Citations

• Higher frequency of adding salt to foods increases the risk of low bone mineral density in individuals over 60 - A Mendelian randomization study
  Ying Li, Yuhan Wang, Lianying Guo, Ye Yu, Mengqi Jiang, Lili Deng, Qingyi Zhou, Lu Sun, Xu Feng, Zhuo Zhang
  Nutrición Hospitalaria.2025;[Epub]     CrossRef

Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visit family physicians. The aim of this article was to describe a case of delayed-onset ACEIIA and to present a concise scoping review. Using a case report and a scoping review study design, we report a case of ACEIIA, with clinically confirmed diagnosis. The symptoms resolved after replacing the offending ACEI with another antihypertensive agent. After excluding other causes of perioral swelling and discontinuation of ACEI, the patient was symptom-free within a few days thereafter. Based on this case presentation, we performed a meta-narrative scoping review including up-todate diagnosis and management of ACEIIA, based on published data in English, French, and German from inception to April 1, 2021. Patients with angioedema of unknown origin should be cautiously examined to rule out oral diseases, including allergy to dental materials and drug-induced angioedema. Clinicopathological aspects and current treatment guidelines for ACEI-associated angioedema are also presented.

Citations

• A stepwise approach to chainsaw kickback injury of the nasoorbital complex: a case-based meta-narrative review
  Poramate Pitak-Arnnop, Ornvenus Nimitwongsakul, Nattapong Sirintawat, Keskanya Subbalekha, Christian Stoll, Jean-Paul Meningaud
  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2024; 138(1): e1.     CrossRef

The incidence of diabetes mellitus (DM) is increasing exponentially globally, with 90% of the confirmed cases being type 2 DM. The global incidence of DM is expected to increase by 48% during 2017–2045. The coronavirus disease 2019 (COVID-19) pandemic continues to have a massive impact on human health, causing sudden lifestyle changes through quarantine measures, such as lockdown, social distancing, various curfews, and isolation at home. This in turn might increase the risk of developing numerous chronic diseases, such as DM, obesity, and cardiovascular diseases, which increase the severity of COVID-19. To this end, we performed a comprehensive review to determine viable measures for the prevention of DM and its subsequent upsurge globally. Additionally, we have determined strategies that should be adopted globally to ensure a healthy lifestyle during the COVID-19 pandemic and later.

Citations

• Enhancement of Virtues: Key to a Healthy Lifestyle against Chronic Diseases and Future Health Crisis
  Dalmacito A. Cordero Jr.
  Korean Journal of Family Medicine.2023; 44(4): 244.     CrossRef

Background
Dietary Na⁺ or Na⁺/K⁺ ratio has been reported to be associated with bone mineral density (BMD). However, this remains unclear, and only a few studies have been reported on the Korean population. Therefore, this study aimed to determine the association between dietary Na⁺, K⁺, and Na⁺/K⁺ ratios and BMD in middle-aged Korean women.
Methods
This study used data from the Korea National Health and Nutrition Examination Survey 2008–2011. A total of 3,690 women aged >50 years were included. Study participants were classified into quartiles (lowest quartile Q1–highest quartile Q4) according to dietary Na⁺, K⁺, and Na⁺/K⁺ ratio, and we examined the association of these parameters with BMD. Total femur and lumbar spine BMD were measured using dual-energy X-ray absorptiometry. Multiple linear regression analyses were performed using IBM SPSS ver. 19.0.
Results
The mean age was 62 years, and a significant negative trend in the β-coefficient regarding dietary Na⁺ was only observed in the total femur BMD. However, the total femur and lumbar spine BMD decreased from Q1 to Q4 regarding the dietary Na⁺/K⁺ ratio (P-value for trend: 0.044 for total femur BMD and 0.002 for lumbar spine BMD).
Conclusion
A significant negative trend in the β-coefficient for both total femur and lumbar spine BMD was observed regarding the Na⁺/K⁺ ratio. Therefore, based on the results of this study, a higher dietary Na⁺/K⁺ ratio may be associated with a lower BMD.

Citations

• Bioactive Compounds and Health Functions of Plums: Current Status and Future Opportunities
  Ming-Qiang Xu, Samuel Ariyo Okaiyeto, Xiao-Xiao Niu, Qing-Hui Wang, Sriram K. Vidyarthi, Haiou Wang, Li-Zhen Deng, Parag Prakash Sutar, Hong-Wei Xiao
  Food Reviews International.2025; 41(5): 1360.     CrossRef
• Does Changing the Ratio of Dietary Sodium-to-Potassium Intake Affect Bone Mineral Density?
  Soo Young Kim
  Korean Journal of Family Medicine.2023; 44(1): 1.     CrossRef

Background
A total of 8,303 individuals (4.3%) with adverse reactions (n=191,860) after vaccination developed serious conditions or died. Such health developments could cause people not vaccinated yet or waiting for a booster shot to become fearful of the vaccination.
Methods
The 3-month (July–September 2021) clinical data of 41 patients from the family medicine department of a single medical center were analyzed retrospectively to determine risk factors and to investigate the clinical course to identify the cause of symptoms in detail.
Results
A significant number of older adults aged over 50 years reported experiencing general weakness (P=0.026) but fewer incidences of fever than patients aged 50 years or younger (P=0.011). Eighteen of the 41 patients were requested to visit more than twice or consult a specialist. In 14 patients, the symptoms were explained by other medical causes.
Conclusion
The primary physician has a pivotal role in thoroughly evaluating patients who complain of adverse effects after vaccination, considering the broad multitude of symptoms and medical conditions presented. To thoroughly evaluate and appropriately advise patients with adverse reactions to their chosen vaccine, taking detailed medical history and nutritional counseling are required to identify possible underlying causes, resolve symptoms, and educate them on self-care and regarding vaccines.

Citations

• Correspondence: Clinical Course of Adverse Effects after COVID-19 Vaccination
  Amnuay Kleebayoon, Viroj Wiwanitkit
  Korean Journal of Family Medicine.2023; 44(5): 299.     CrossRef

Background
Human immunodeficiency virus (HIV), the agent responsible for acquired immunodeficiency syndrome, remains a worldwide public health problem. Therefore, this study aimed to assess Portuguese healthcare students’ knowledge of HIV, identify risk behaviors for HIV transmission, and assess the frequency of HIV testing and its dissemination by general practitioners.
Methods
A cross-sectional observational study was conducted using an anonymous questionnaire published online. The questionnaire was administered to Portuguese healthcare students who voluntarily agreed to participate in the study after clarifying its objectives and procedures.
Results
Most students were aware of the three main HIV transmission routes; however, 66.3% were unaware of the level A recommendation for HIV screening in adolescents and adults. In addition, 59.6% of the students were never informed by their general practitioner about HIV screening tests or risk behaviors for HIV transmission. Of the sample, 78.9% had never been tested for HIV infection. Of the 74.6% of sexually active students, 82.0% had or had already had unprotected sex (without a condom). Men showed riskier sexual behaviors than women. None of the inquiries reported intravenous drug use, and most students (69.9%) never shared personal objects.
Conclusion
General practitioners and awareness campaigns need to alert and disseminate HIV screening tests. Sexual health and risk behaviors should be addressed more frequently in schools to educate this population because prevention is the best strategy against HIV transmission/contraction.

Citations

• Sexual awareness, high-risk sexual behaviors and HIV testing: a cross-sectional survey among university students in Xuzhou, Jiangsu
  Hualing Li, Qi Wu, Qinghan Li, Enze Gao, Dehui Yin
  Frontiers in Public Health.2025;[Epub]     CrossRef

Background
A written asthma action plan (WAAP) is one of the treatment strategies to achieve good asthma control in children.
Methods
This randomized controlled trial was conducted to observe the effect of WAAP on asthma control and quality of life using the Asthma Control Questionnaire and Pediatric Asthma Quality of Life Questionnaire (PAQLQ) at baseline and after 3 months. A repeated measure analysis of variance was used to analyze the mean score difference between the two groups.
Results
There was no significant difference in mean score for asthma control at baseline between groups (F[degree of freedom (df)]=1.17 [1, 119], P=0.282). However, at 3 months, a significant difference in mean scores between groups was observed (F[df]=7.32 [1, 119], P=0.008). The mean±standard deviation (SD) scores in the intervention and control groups were 0.96±0.53 and 1.21±0.49, respectively. For the analysis of the PAQLQ, no significant difference was observed in the mean score for the quality of life baseline in both groups. There were significant mean score changes for the quality of life (F[df]=10.9 [1, 119], P=0.001) at 3 months follow-up, where those in the intervention group scored a mean±SD score of 6.19±0.45, and those in the control group scored 5.94±0.38. A time-group interaction analysis using repeated-measures analysis of variance showed significant differences in mean score changes (F[df]=5.03 [1, 116], P=0.027) and (F[df]=11.55 [1, 116], P=0.001) where a lower mean score was observed in the intervention group, indicating better asthma control and quality of life, respectively. A significant (P<0.001) negative Pearson correlation between asthma control and quality of life (-0.65) indicated a moderate correlation.
Conclusion
WAAP, along with standard asthma treatment, improves asthma care.

Citations

• Accessibility of health and preventive care for patients with bronchial asthma
  L.Yu. Nikitina, O.S. Mishina, V.V. Gainitdinova, T.Yu. Gneusheva, O.V. Nagatkina, R.M. Aynetdinov, G.V. Lukyanova, I.A. Bogdanov, I.A. Deev, S.N. Avdeev
  Journal of Respiratory Medicine.2025; 1(1): 15.     CrossRef
• The impact of asthma education grounded in virtual reality technology upon the quality of life of pediatric patients with bronchial asthma
  Huijuan Wang, Qing Dong, Xiaowei Wang
  Frontiers in Pediatrics.2025;[Epub]     CrossRef
• The utility of the necessity-concerns framework (NCF) in explaining adherence and parental beliefs about controller medication in Saudi Arabian children with asthma
  Marja A. Alyami, Mohammed M. Alyami, Ahmed H Alasimi, Jaber S. Alqahtani, Abdullah A. Alqarni, Abdulelah M. Aldhahir
  Journal of Asthma.2024; 61(5): 436.     CrossRef

Background
Erythropoietin (EPO), which is associated with anemia, exerts neuroprotective effects in ischemic stroke. In cases of stenosis or narrowing of the main cerebral blood vessel, the prognosis is favorable if collateral blood circulation is well developed in acute stroke. Several studies have investigated the relationship between EPO administration and stroke outcomes. The present study investigated the correlation between serum EPO level and cerebral collateral circulation, which could result in favorable clinical outcomes.
Methods
The study subjects were patients diagnosed with acute ischemic stroke who underwent initial brain magnetic resonance imaging between January 2020 and March 2022. Following brain computed tomography perfusion for collateral flow, serum EPO levels were measured. Collaterals were assessed according to the Mass system and divided into good collateral (GC) or poor collateral (PC) groups. Serum EPO levels were determined using a chemiluminescence immunoassay method. A correlation coefficient analysis was conducted to determine the correlation between serum EPO levels and GC. A receiver operating characteristic curve analysis determined the cutoff value of EPO for GC.
Results
Serum EPO levels were significantly higher in the GC than that in the PC group (P<0.05). The cut-off level of serum EPO for a good outcome was 9.1 mIU/mL.
Conclusion
A high serum EPO (>9.1 mIU/mL) could be a marker of GC in patients with acute ischemic stroke that predicts good clinical outcomes.

Citations

• Reinforcement of Transdural Angiogenesis: A Novel Approach to Treating Ischemic Stroke With Cerebral Perfusion Impairment
  Ji Man Hong, Hee Sun Shin
  Journal of Stroke.2025; 27(1): 30.     CrossRef
• Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway
  Zhenxing Tao, Pengpeng Li, Yushi Tang, Wenhui Yang, Yilu Li, Jieqiong Yang, Jiajia Tian, Yating Zhang, Yan Zou, Bai Xu, Xudong Zhao
  Neurochemical Research.2025;[Epub]     CrossRef
• Albumin levels and cerebral collateral circulation in patients with acute ischemic stroke due to intracranial arteriosclerotic: A propensity score-matched analysis
  Le Wang, Qiang Shi, Yi-dong Xue, Chan Cao, Ying-Ying Zheng
  Medicine.2024; 103(21): e38254.     CrossRef

Background
Serum thyroid-stimulating hormone (TSH) levels change during body weight reduction. However, the changes that occur during short-term body weight control interventions remain controversial. Thus, this study aimed to evaluate the changes in TSH levels according to body fat reduction.
Methods
We performed a 3-month intervention study involving partial meal replacement. Forty-nine participants completed the study. Correlations between changes in TSH levels and other body composition parameters were determined. The subjects were divided into two groups according to their body fat reduction (>1 kg, n=20; <1 kg, n=29). The changes in metabolic parameters, including TSH levels, were compared. For significant values, a multivariate analysis was performed after adjustment to evaluate the relationship between TSH changes and body fat reduction.
Results
The 3-month intervention caused favorable changes in body proportions and metabolic parameters. TSH levels changed significantly only after changes in total body fat, showing a partial correlation. Changes in TSH levels were significantly different between groups (P=0.014). Moreover, the change in TSH levels was significantly different after adjustment (P=0.012).
Conclusion
A body fat reduction, especially >1 kg, can reduce serum TSH concentrations in subjects with metabolic syndrome after short-term body weight intervention.