Noncommunicable diseases (NCDs), including cancer, diabetes, hypertension, cardiovascular diseases, and chronic respiratory conditions, are the leading global causes of morbidity and mortality. Depression frequently co-occurs with these conditions, and may significantly reduce medication adherence, thereby worsening health outcomes. This narrative review examines the relationship between depression and medication adherence in patients with NCDs. It also highlights the current challenges in managing this comorbidity and explores potential strategies for improving adherence outcomes. Most studies have reported a significant negative association between depression and medication adherence in diverse NCD populations. Depressive symptoms impair motivation, memory, and executive functioning, which are essential for the maintenance of treatment regimens. However, inconsistencies across studies have been observed due to variability in the measurement of depression and adherence, study design, and control of confounding factors. Despite evidence from high-income countries supporting integrated care models such as collaborative care and cognitive behavioral therapy, implementation of these models in low- and middle-income countries remains limited. Emerging strategies, including task shifting, digital health tools (e.g., mobile health apps and telemedicine), and community-based support systems, offer promising avenues for intervention. Addressing this issue requires integrated and scalable interventions tailored to local contexts. Future research should focus on longitudinal and interventional studies, particularly in resource-limited settings, to inform policies and practices.

Citations

• The Critical Role of Medicine Adherence in Management of Chronic Conditions: A Review Article
  Lucky Norah Katende-Kyenda
  Journal of Mind and Medical Sciences.2026; 13(1): 2.     CrossRef
• Psychological distress and its influence on medication adherence among patients with co-morbid hypertension and diabetes: an explanatory sequential mixed-methods study
  Adwoa Oforiwaa Kwakye, Ama Agyeman-Dua, Joana Afful Larry-Afutu, Irene Akwo Kretchy
  BMC Public Health.2026;[Epub]     CrossRef
• The Mental Health–Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications
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  Medical Sciences.2026; 14(1): 138.     CrossRef
• Patient-Drug Related Factors Associated with Nonadherence to Chronic Treatment in Patients Attending a Primary Care Setting in South Africa
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  Hospitals.2026; 3(2): 8.     CrossRef
• Advances in the treatment of pediatric hidradenitis suppurativa: emerging therapies and future directions
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  Current Opinion in Pediatrics.2026; 38(4): 389.     CrossRef
• Health behaviors, lifestyle factors, and healthcare challenges in family medicine: a comprehensive review of recent evidence from Asian populations
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  Korean Journal of Family Medicine.2025; 46(4): 215.     CrossRef
• Assessment of depression and anxiety in Tunisian patients with chronic diseases: impact on quality of life and medication adherence
  Cherif Farah, Masmoudi Rim, Frikha Chourouk, Abdelkefi Mariam, Guermazi Fatma, Emna Meziou, Feki Ines, Masmoudi Jawaher
  Frontiers in Psychiatry.2025;[Epub]     CrossRef