Korean Journal of Family Medicine

"Dong Hyeok Shin"

Original Articles

The Efficacy and Safety of a Combined Alendronate and Calcitriol Agent (Maxmarvil): A Postmarketing Surveillance Study in Korean Postmenopausal Women with Osteoporosis: Hee-Won Suh, Hyun-Ok Kim, Young Sik Kim, Sung Sunwoo, Jung Ah Lee, Hye-Ree Lee, Byungsung Kim, Dae Hyun Kim, Youn Seon Choi, Yoo Seock Cheong, Keunsang Yum, Yun Jun Yang, Byung-Yeon Yu, Chung Hwan Cho, Sat-Byul Park, Dong Hyeok Shin; Korean J Fam Med 2012;33(6):346-355. Published online November 27, 2012; DOI: https://doi.org/10.4082/kjfm.2012.33.6.346

Abstract
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Background

Combined therapy with alendronate and calcitriol may have additive effects on bone density. An observational study was performed to evaluate the efficacy and safety of Maxmarvil, a combinative agent of alendronate (5 mg) and calcitriol (0.5 µg), and to identify factors associated with efficacy.

Methods

A total of 568 postmenopausal women with osteoporosis were enrolled by family physicians in 12 hospitals. The study subjects took Maxmarvil daily for 12 months. Questionnaires about baseline characteristics, socioeconomic status, and daily calcium intake were completed at the first visit. Adverse events were recorded every 3 months and bone mineral density (BMD) in the lumbar spine was measured using dual-energy X-ray absorptiometry at baseline and after 12 months. We evaluated the efficacy and safety of Maxmarvil, and the factors related to BMD improvement.

Results

A total of 370 patients were included in final analysis. The median BMD was 0.81 ± 0.12 g/cm² at pre-treatment and 0.84 ± 0.13 g/cm² after one year. The average BMD improvement was 3.4% ± 6.4% (P < 0.05), and 167 (45.1%) patients showed improvement. Factors associated with improved BMD were continuation of treatment (odds ratio [OR], 2.41; 95% confidence interval [CI], 1.15 to 5.07) and good compliance (OR, 2.54; 95% CI, 1.29 to 5.00). Adverse events were reported by 35 of the 568 patients, with the most common being abdominal pain and dyspepsia.

Conclusion

Maxmarvil was found to be safe, well tolerated and effective in osteoporosis treatment. Continuation of treatment and good compliance were the factors associated with efficacy.

Citations

Citations to this article as recorded by

Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study
Kui Han, Xiaoyan Wang
Medicine.2024; 103(45): e40171. CrossRef
Fracture Preventing Effects of Maxmarvil® Tablets (Alendronate 5 mg + Calcitriol 0.5 µg) in Patients with Osteoporosis
Jun-Il Yoo, Yong-Chan Ha, Ye-Yeon Won, Kyu-Hyun Yang, Sang-Bum Kim, Ju-Hyung Yoo, Dong-Soo Kim
Journal of Bone Metabolism.2017; 24(2): 91. CrossRef
The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF)
Luisella Cianferotti, Claudio Cricelli, John A. Kanis, Ranuccio Nuti, Jean-Y. Reginster, Johann D. Ringe, Rene Rizzoli, Maria Luisa Brandi
Endocrine.2015; 50(1): 12. CrossRef

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Attitudes of medical students and housestaff toward euthanasia.: Joo Tae Kim, Kyung Chul Kim, Dong Hyeok Shin, Hang Suk Cho, Jae Yong Shim, Hye Ree Lee; J Korean Acad Fam Med 2001;22(10):1494-1502. Published online October 1, 2001

Abstract
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Background
: Medical decisions concerning the prolongation of life. the right to die and euthanasia are among the most extensively discussed issues within medicine and law today. The purpose of this study was to evaluate the attitudes of medical of students and housestaff toward euthanasia.

Methods : From July 15 to september 15 of the 1998, the responses of 180 medical students and 132 housestaff to a self-adbministered questionnaire were analyzed to identify attitudes toward euthanasia. Over 312 respondents about attitudes toward euthanasia, the analysis of differences between proportions was made by the Chi-square test.

Results : About 69.9% of the respondents thought euthanasia should be legalized. The findings suggest that Buddhists (77.5%) and non-religious groups (88.1%) tend to support euthanasia more than Christians. Futhermore, medical students (74.4%) support euthanasia more than housestaffs(63.6%), male(75.1%) more often than female(57.9%). about 73.1% of the respondents said that active euthanasia is not justifiable, and 79.2% said that they do not like performing active euthanasia. In respect to passive euthanasia, 69.0% said that it is not ethically justifiable, but 63.0% would perform this as if it were legal. Housestaffs of internal medicine (76.9%) were more willing to do euthanasia than pediatrics (70.0%), surgery (63.6%), family practice (53.8%) and Ob/Gyn(33.3%).

Conclusion : Respondents have positive attitudes toward legalization of euthanasia.. Most considered that passive euthanasia is not morally justifiable. But if it were legalized, they would still be disturbed by active euthanasia. The opinions of physician and medical students directly affect patient care and their attitudes must be considered if clear plicies are to be developed concerning euthanasia.