Background Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults.
Methods The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined.
Results Higher serum UA levels were associated with decreased levels of d-ROMs (P<0.05). The UA levels were positively associated with BAP levels (P<0.001).
Conclusion Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans.
Citations
Citations to this article as recorded by
Oxidative stress and type 2 diabetes: the development and the pathogenesis, Jordanian cross-sectional study Khalid M Abu Khadra, Mohammad Izzat. Bataineh, Ahmad Khalil, Jumana Saleh European Journal of Medical Research.2024;[Epub] CrossRef
The relationship between anemia and hyperuricemia and hypertension in Korean adults: the Korea National Health and Nutrition Examination Survey 2016–2018 Sang Muk Park, Mi Young Gi, Ju Ae Cha, Hyun Ho Sung, So Young Park, Cho Hee Park, Hyun Yoon Current Medical Research and Opinion.2023; 39(6): 819. CrossRef
Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells Reyhane Ebrahimi, Parvin Pasalar, Hajar Shokri, Maryam Shabani, Solaleh Emamgholipour Journal of Physiology and Biochemistry.2022; 78(2): 343. CrossRef
Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS Ángela Hernández-Ruiz, Belén García-Villanova, Eduardo J. Guerra-Hernández, Cayetano Javier Carrión-García, Pilar Amiano, María-José Sánchez, Esther Molina-Montes Antioxidants.2022; 11(2): 300. CrossRef
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus Iuliia Azarova, Elena Klyosova, Alexey Polonikov European Journal of Clinical Investigation.2022;[Epub] CrossRef
Usefulness of routine blood test-driven clusters for predicting acute exacerbation in patients with asthma Ji Hyun Oh, Kyung-Min Ahn, Soo Jie Chung, Ji-Su Shim, Heung-Woo Park Respiratory Medicine.2020; 170: 106042. CrossRef
The Postprandial Effect of Anthocyanins on Cardiovascular Disease Risk Factors: a Systematic Literature Review of High-Fat Meal Challenge Studies Vinicius Andre do Rosario, Jaclyn Spencer, Katrina Weston-Green, Karen Charlton Current Nutrition Reports.2020; 9(4): 381. CrossRef
Nephrotoxic effects caused by co-exposure to noise and toluene in New Zealand white rabbits: A biochemical and histopathological study Amirreza Abouee-Mehrizi, Yahya Rasoulzadeh, Mehran Mesgari-Abbasi, Ahmad Mehdipour, Abbas Ebrahimi-Kalan Life Sciences.2020; 259: 118254. CrossRef
Association of sleep quality and sleep duration with serum uric acid levels in adults Yu-Tsung Chou, Chung-Hao Li, Wei-Chen Shen, Yi-Ching Yang, Feng-Hwa Lu, Jin-Shang Wu, Chih-Jen Chang, Xianwu Cheng PLOS ONE.2020; 15(9): e0239185. CrossRef
Background Metabolic syndrome (MS) is a well-known risk factor of cardiovascular diseases that is focused on central obesity. Recent studies have reported the association between pericardial adipose tissue (PAT) volume and MS. However, no studies have demonstrated the cutoff PAT volume that represents the best association with MS.
Methods The data of 374 subjects were analyzed cross-sectionally to compare PAT, measured on coronary multidetector computed tomography, and various metabolic parameters according to MS. After PAT volumes were divided into tertiles, various metabolic parameters were compared among tertiles; furthermore, the odds ratio for developing MS was calculated. Finally, we demonstrated the cutoff PAT volume that represented the best association with MS by using the receiver-operating characteristic curve.
Results We found that 27.5% of the subjects had MS, and the mean PAT volume was 123.9 cm3 . PAT showed a significant positive correlation with body mass index, waist circumference, and levels of glucose, triglyceride, high-sensitivity C-reactive protein, uric acid, and homocysteine, but a negative correlation with high-density lipoprotein cholesterol. Furthermore, after dividing into tertiles, PAT volume was also significantly associated with various metabolic parameters. The odds ratio for having MS was 4.19 (95% confidence interval, 2.27–7.74) in the top tertile of PAT volumes after adjusting for age, sex, and smoking. The cutoff PAT volume that represented the best association with MS was 142.2 cm3 .
Conclusion PAT was significantly associated with MS and various metabolic parameters. The cutoff PAT volume of 142.2 cm3 showed the best association with MS.
First
Prev
