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"Kyu-Nam Kim"

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"Kyu-Nam Kim"

Original Articles

Background
The blood level of alanine aminotransferase (ALT) is associated with increased coronary heart disease (CHD) risk. However, its use as an independent factor for CHD risk prediction remains unclear in Asian populations. The purpose of this study was to examine the association between serum ALT levels and CHD risk in Koreans.
Methods
This was a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011). The ALT levels of 3,215 individuals were analyzed. The Framingham Risk Score (FRS) modified by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) was used to compute the 10-year CHD risk prediction.
Results
Positive correlations were established between log-transformed ALT concentration and FRS (r=0.433, P<0.001). After adjusting for body mass index, low-density lipoprotein cholesterol, the amount of alcohol intake, and gamma-glutamyl transferase, the odds ratio (95% confidence interval) for intermediate or greater risk of 10- year CHD prediction (10-year risk ≥10%) for the lowest quartile of participants was 2.242 (1.405–3.577) for the second quartile, 2.879 (1.772–4.679) for the third quartile, and 3.041 (1.789–5.170) for the highest quartile.
Conclusion
In Koreans, a higher serum ALT concentration was significantly correlated with 10-year CHD risk prediction according to NCEP ATP III guidelines.

Citations

Citations to this article as recorded by  
  • Endothelin-converting Enzyme-1b Genetic Variants Increase the Risk of Coronary Artery Ectasia
    Gulcin Ozkara, Ezgi Irmak Aslan, Fidan Malikova, Cagatay Aydogan, Ozgur Selim Ser, Onur Kilicarslan, Sadiye Nur Dalgic, Ahmet Yildiz, Oguz Ozturk, Hulya Yilmaz-Aydogan
    Biochemical Genetics.2025; 63(2): 1806.     CrossRef
  • Early prediction of cardiovascular events following treatments in female breast cancer patients: Application of real-world data and artificial intelligence
    Quynh T.N. Nguyen, Shwu-Jiuan Lin, Phung-Anh Nguyen, Phan Thanh Phuc, Min-Huei Hsu, Chun-Yao Huang, Chin-Sheng Hung, Christine Y. Lu, Jason C. Hsu
    The Breast.2025; 81: 104438.     CrossRef
  • An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses
    Hongxi Yang, Yuhan Jiang, Ju Guo, Jianhua Wang, Xin Ma, Kexin Chen, Hua Yan, Ying Yu, Dandan Huang
    European Journal of Preventive Cardiology.2024;[Epub]     CrossRef
  • Evaluating SORT1 and SESN1 genes expression in peripheral blood mononuclear cells and oxidative stress status in patients with coronary artery disease
    Tayebe Ghiasvand, Jamshid Karimi, Iraj Khodadadi, Amirhossein Yazdi, Salman Khazaei, Zahra Abedi Kichi, Seyed Kianoosh Hosseini
    BMC Genomic Data.2024;[Epub]     CrossRef
  • Daily intake of heat-killed Lactobacillus plantarum L-137 improves inflammation and lipid metabolism in overweight healthy adults: a randomized-controlled trial
    Yusuke Tanaka, Yoshitaka Hirose, Yoshihiro Yamamoto, Yasunobu Yoshikai, Shinji Murosaki
    European Journal of Nutrition.2020; 59(6): 2641.     CrossRef
  • 5,553 View
  • 89 Download
  • 7 Web of Science
  • 5 Crossref
A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue
Sang-Hoon Lee, Doo-Yeoun Cho, Seok-Hoon Lee, Kyung-Sun Han, Sung-Won Yang, Jin-Ho Kim, Su-Hyun Lee, Soo-Min Kim, Kyu-Nam Kim
Korean J Fam Med 2019;40(1):2-8.   Published online October 26, 2018
DOI: https://doi.org/10.4082/kjfm.17.0064
Background
This double-blind, randomized controlled design study aimed to assess the dose-dependent effects of synbiotics on gastrointestinal symptoms of and fatigue in irritable bowel syndrome (IBS).
Methods
Thirty subjects with IBS were randomly assigned into the following three groups and received 2 capsules a day for 8 weeks: (1) high-dose (2 capsules of synbiotics); (2) low-dose (1 capsule of synbiotics and 1 capsule of placebo); and (3) placebo (2 capsules of placebo). At baseline and 8 weeks, they completed the study questionnaires.
Results
Two subjects in the high-dose group were lost to follow-up, leaving a total of 28 patients for the analysis. After 8 weeks, abdominal discomfort, abdominal bloating, frequency of formed stool, fatigue Visual Analog Scale (VAS), and Multidimensional Fatigue Inventory were significantly different among the groups (P=0.002, 0.006, 0.007, 0.028, and 0.041, respectively, by Kruskal-Wallis test). However, only abdominal discomfort, abdominal bloating, frequency of formed stool, and fatigue VAS were significantly improved in the high-dose group compared with those in the placebo group (P=0.002, 0.003, 0.002, and 0.013, respectively) by Mann-Whitney test with Bonferroni correction. No adverse drug reactions were reported.
Conclusion
High-dose synbiotics were superior to placebo in improving bowel symptoms and fatigue of IBS patients, suggesting that synbiotic dosage plays an important role in the treatment of IBS.

Citations

Citations to this article as recorded by  
  • Effectiveness of a Balanced Nine-Strain Synbiotic in Primary-Care Irritable Bowel Syndrome Patients—A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial
    Henning Sommermeyer, Krzysztof Chmielowiec, Malgorzata Bernatek, Pawel Olszewski, Jaroslaw Kopczynski, Jacek Piątek
    Nutrients.2024; 16(10): 1503.     CrossRef
  • The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis
    Youhe Wu, Yuetong Li, Qi Zheng, Lanjuan Li
    Nutrients.2024; 16(13): 2114.     CrossRef
  • Synbiotics as Treatment for Irritable Bowel Syndrome: A Review
    Henning Sommermeyer, Jacek Piątek
    Microorganisms.2024; 12(7): 1493.     CrossRef
  • The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson’s disease: A double-blind, placebo-controlled, randomized controlled trial
    Sanaz Mehrabani, Fariborz Khorvash, Zahra Heidari, Maryam Tajabadi-Ebrahimi, Reza Amani
    Journal of Functional Foods.2023; 100: 105397.     CrossRef
  • Irritable Bowel Syndrome: Treating the Gut and Brain/Mind at the Same Time
    Maleesha Jayasinghe, John A Damianos, Omesh Prathiraja, Melysze D Oorloff, Gairu M Nagalmulla K, Adithya Nadella, Dilushini Caldera, Ali Mohtashim
    Cureus.2023;[Epub]     CrossRef
  • The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer: a randomized placebo-controlled double-blind clinical trial
    Yasaman Khazaei, Ali Basi, Maria Luz Fernandez, Hossein Foudazi, Rafat Bagherzadeh, Farzad Shidfar
    BMC Complementary Medicine and Therapies.2023;[Epub]     CrossRef
  • The role of gut microbiota in the treatment of irritable bowel syndrome
    Hamed Ebrahimzadeh Leylabadlo, Fatemah Sadeghpour Heravi, Elghar Soltani, Amin Abbasi, Hossein Samadi Kafil, Mahdi Parsaei, Sarvin Sanaie, Zainab Ahmadian, Reza Ghotaslou
    Reviews in Medical Microbiology.2022; 33(1): e89.     CrossRef
  • How to Improve Health with Biological Agents—Narrative Review
    Anna Zawistowska-Rojek, Stefan Tyski
    Nutrients.2022; 14(9): 1700.     CrossRef
  • Why Use Nutraceutical Strategies for the Irritable Bowel Syndrome?
    Flavia di Michele
    Current Medicinal Chemistry.2022; 29(12): 2075.     CrossRef
  • Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial
    J.A. Maldonado-Lobón, R. Blanco-Rojo, J. Maldonado, M.A. Ali, M.V. Almazán, A. Suanes-Cabello, E. Callejón, R. Jaldo, M.R. Benavídes, A.M. Negrillo, A. Sañudo, C. Rodríguez, O. Bañuelos, J. Fonollá, M. Olivares, _ _
    Beneficial Microbes.2021; 12(1): 55.     CrossRef
  • Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome
    Elemer Simon, Lavinia Florina Călinoiu, Laura Mitrea, Dan Cristian Vodnar
    Nutrients.2021; 13(6): 2112.     CrossRef
  • Evaluation of the Effect of Limosilactobacillus fermentum CECT5716 on Gastrointestinal Infections in Infants: A Systematic Review and Meta-Analysis
    Belén Pastor-Villaescusa, Ruth Blanco-Rojo, Mónica Olivares
    Microorganisms.2021; 9(7): 1412.     CrossRef
  • Probiotics, Prebiotics, and Synbiotics in the Irritable Bowel Syndrome Treatment: A Review
    Agnieszka Chlebicz-Wójcik, Katarzyna Śliżewska
    Biomolecules.2021; 11(8): 1154.     CrossRef
  • The effects of synbiotic supplementation on thyroid function and inflammation in hypothyroid patients: A randomized, double‑blind, placebo‑controlled trial
    Sepide Talebi, Mozhgan Karimifar, Zahra Heidari, Hamed Mohammadi, Gholamreza Askari
    Complementary Therapies in Medicine.2020; 48: 102234.     CrossRef
  • Current and emerging pharmacological approaches for treating diarrhea-predominant irritable bowel syndrome
    Akhil Munjal, Bhavtosh Dedania, Brooks D. Cash
    Expert Opinion on Pharmacotherapy.2020; 21(1): 63.     CrossRef
  • Irritable Bowel Syndrome and Synbiotics
    Soo Young Kim
    Korean Journal of Family Medicine.2019; 40(1): 1.     CrossRef
  • Anti-Inflammatory Diets and Fatigue
    Ulrike Haß, Catrin Herpich, Kristina Norman
    Nutrients.2019; 11(10): 2315.     CrossRef
  • Research Progress in Fecal Microbiota Transplantation as Treatment for Irritable Bowel Syndrome
    Yao Wang, Fengling Zheng, Shan Liu, Huanhuan Luo
    Gastroenterology Research and Practice.2019; 2019: 1.     CrossRef
  • 12,098 View
  • 307 Download
  • 19 Web of Science
  • 18 Crossref
Case Report
Epiglottic Cyst Incidentally Discovered During Screening Endoscopy: A Case Report and Review of Literature
Seung-Hwa Lee, Duck-Joo Lee, Kwang-Min Kim, Kyu-Nam Kim, Sang-Wook Seo, Young-Kyu Park, Sung-Min Cho, Young-Ah Choi, Jung-Un Lee, Dong-Ryul Lee
Korean J Fam Med 2014;35(3):160-166.   Published online May 22, 2014
DOI: https://doi.org/10.4082/kjfm.2014.35.3.160

From the endoscopists' point of view, although the main focus of upper gastrointestinal endoscopic examination is the esophagus, stomach, and duodenum (usually bulb and 2nd portion including ampulla of Vater), the portions of the upper airway may also be observed during insertion and withdrawal of the endoscope, such as pharynx and larynx. Thus, a variety of pathologic lesions of the upper airway can be encountered during upper endoscopy. Among these lesions, an epiglottic cyst is relatively uncommon. The cyst has no malignant potential and mostly remains asymptomatic in adults. However, if large enough, epiglottic cysts can compromise the airway and can be potentially life-threatening when an emergency endotracheal intubation is needed. Thus, patients may benefit from early detection and treatment of these relatively asymptomatic lesions. In this report, we present a case of epiglottic cyst in an asymptomatic adult incidentally found by family physician during screening endoscopy, which was successfully removed without complication, using a laryngoscopic carbon dioxide laser.

Citations

Citations to this article as recorded by  
  • When benign lesions cause significant morbidity: A case of a massive epiglottic cyst
    Walter Yung Chwen Lim, Atikah Rozhan, Chenthilnathan Periasamy
    Visual Journal of Emergency Medicine.2025; 39: 102260.     CrossRef
  • Incidental finding of two epiglottic cysts: Case report and literature review
    Razan Alosaimi, Lara Alyahiwi, Abdulrahman Fahad Aljadoa, Bandar Abushal, Fahad Mohammed Alruwaili, Abdulmajeed Zakzouk
    International Journal of Surgery Case Reports.2025; 133: 111537.     CrossRef
  • An Uncommon Epiglottic Cyst Presentation in an Adolescent: A Case Report and Literature Review
    Hisham Alrashdan, Khaldoun Alshugran, Osama M Alshiyyab, Jawad F Khasawneh, Ethar N Ibrahim
    Cureus.2024;[Epub]     CrossRef
  • Giant Epiglottic Cyst: A Comprehensive Case Report and Literature Review
    Po-Hsuan Jeng, Tien-Ru Huang, Cheng-Ping Shih
    Ear, Nose & Throat Journal.2024;[Epub]     CrossRef
  • Epiglottic Epidermoid Cyst: Cadaveric Case Report and Clinical-Surgical Applications
    Juan J Cardona, Katie Stormes, Neal Jackson, Yushi Abe, Joe Iwanaga, R. Shane Tubbs
    Cureus.2023;[Epub]     CrossRef
  • Pedunculated Fibrolipoma of the Hypopharynx: A Case Report
    Tae Seong Eo, Hyang Ae Shin, Jeong Hae Kie, Ji-Hoon Kim
    Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics.2022; 33(2): 115.     CrossRef
  • 9,900 View
  • 72 Download
  • 3 Web of Science
  • 6 Crossref
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