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"Mi Kyeong Oh"

Original Articles

Relationship between Neck Length, Sleep, and Cardiovascular Risk Factors
Tae Seung Han, Mi Kyeong Oh, Su Min Kim, Hyun Ju Yang, Bum Soon Lee, Soon Yeob Park, Won Joon Lee
Korean J Fam Med 2015;36(1):10-21.   Published online January 31, 2015
DOI: https://doi.org/10.4082/kjfm.2015.36.1.10
Background

Neck circumference, as a predicator of obesity, is a well-known risk factor for obstructive sleep apnea and cardiovascular diseases. However, little research exists on neck length associated with these factors. This study explored the association of neck length with sleep and cardiovascular risk factors by measuring midline neck length (MNL) and lateral neck length (LNL).

Methods

We examined 240 patients aged 30 to 75 years who visited a health check-up center between January 2012 and July 2012. Patients with depressive disorder or sleep disturbance were excluded from this study. MNL from the upper margin of the hyoid bone to the jugular notch and LNL from the mandibular angle to the mid-portion of the ipsilateral clavicle were measured twice and were adjusted by height to determine their relationship with sleep and cardiovascular disease risk factors.

Results

Habitual snorers had shorter LNL height ratios (P = 0.011), MNL height ratios in men (P = 0.062), and MNL height ratios in women (P = 0.052). Those snoring bad enough to annoy others had shorter MNL height ratios in men (P = 0.083) and women (P = 0.035). Men with objective sleep apnea had longer distances from the mandible to the hyoid bone to the mandible (P = 0.057). Men with metabolic syndrome had significantly shorter LNL height ratios (P = 0.021), and women with diabetes, hyperlipidemia, and metabolic syndrome had shorter MNL height ratios (P < 0.05).

Conclusion

This study shows that a short neck by measuring the MNL is probably associated with snoring. In addition, MNL is related to cardiovascular disease risk factors in women.

Citations

Citations to this article as recorded by  
  • A multiple linear regression model calculates the anterior neck skin surface area in Chinese individuals: Implications for neck resurfacing and reconstruction
    Rui Li, Jianmin Yang, Zilong Cao, Qiang Yue, Hu Jiao, Jia Tian, Zengjie Yang, Liqiang Liu, Cheng Gan
    Journal of Plastic, Reconstructive & Aesthetic Surgery.2025; 102: 363.     CrossRef
  • Prediction of hypertensive responses associated with interscalene block, a prospective cohort study
    Mahmut Sami Tutar, Ahmet Polat, Rabia Korkmaz, İlhami Aksoy, Fatih Doğar, Ahmet Yildirim, Muhammed Halit Satici, Munise Yildiz, Betul Kozanhan
    BMC Anesthesiology.2025;[Epub]     CrossRef
  • Determinants of Cormack–Lehane grading for glottic exposure in microlaryngeal surgery in Middle Delta Egyptian patients
    Ahmed Zakaria Mahmoud, Mohamed Adel Khalifa, Hassan Moustafa Hegazy, Emad Mohammed Shehata
    The Egyptian Journal of Otolaryngology.2024;[Epub]     CrossRef
  • Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study
    Mayra dos Santos Silva, Dalva Poyares, Luciana Oliveira Silva, Ksdy M. Souza, Monica L. Andersen, Maurice M. Ohayon, Sergio Tufik, Ronaldo D. Piovezan
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • The Gupta Perioperative Risk for Myocardial Infarct or Cardiac Arrest (MICA) Calculator as an Intraoperative Neurologic Deficit Predictor in Carotid Endarterectomy
    Juliana Pereira-Macedo, Beatriz Lopes-Fernandes, Luís Duarte-Gamas, António Pereira-Neves, Joana Mourão, Ahmed Khairy, José Paulo Andrade, Ana Marreiros, João Rocha-Neves
    Journal of Clinical Medicine.2022; 11(21): 6367.     CrossRef
  • The impact of forward head posture on the electromyographic activity of the spinal muscles
    Zaenab Alowa, Walaa Elsayed
    Journal of Taibah University Medical Sciences.2021; 16(2): 224.     CrossRef
  • An Accessible, 16-Week Neck Strength Training Program Improves Head Kinematics Following Chest Perturbation in Young Soccer Athletes
    Enora Le Flao, Andrew W. Pichardo, Sherwin Ganpatt, Dustin J. Oranchuk
    Journal of Sport Rehabilitation.2021; 30(8): 1158.     CrossRef
  • An Alternative Approach to Carotid Endarterectomy in the High Carotid Bifurcation
    Ashley Farhat-Sabet, Brittany O. Aicher, Besher Tolaymat, Vladimir Coca-Soliz, Khanjan H. Nagarsheth, Areck A. Ucuzian, Joshua E. Lubek, Shahab Toursavadkohi
    Annals of Vascular Surgery.2020; 65: 240.     CrossRef
  • The accuracy of neck circumference for assessing overweight and obesity: a systematic review and meta-analysis
    Caroline Kroll, Silmara S. B. S. Mastroeni, Sandra A. Czarnobay, John Paul Ekwaru, Paul J. Veugelers, Marco F. Mastroeni
    Annals of Human Biology.2017; 44(8): 667.     CrossRef
  • Predictive value of craniofacial and anthropometric measures in obstructive sleep apnea (OSA)
    Krishnan Jyothi Remya, Krishnakumar Mathangi, Damal Chandrasekhar Mathangi, Yerlagadda Sriteja, Ramamoorthy Srihari, Soundararajan Govindaraju, David R. Hillman, Peter R. Eastwood
    CRANIO®.2017; 35(3): 162.     CrossRef
  • Prevalence of insomnia and its risk factors in older individuals: a community-based study in four cities of Hebei Province, China
    Yu-Mei Wang, Hong-Guang Chen, Mei Song, Shun-Jiang Xu, Lu-Lu Yu, Lan Wang, Ran Wang, Le Shi, Jia He, Yue-Qin Huang, Hong-Qiang Sun, Cheng-Ying Pan, Xue-Yi Wang, Lin Lu
    Sleep Medicine.2016; 19: 116.     CrossRef
  • Relationship between Neck Length, Sleep, and Psychiatric Disorders: A Psychiatric Aspect
    Cemil Celik, Barbaros Ozdemir, Taner Oznur
    Korean Journal of Family Medicine.2015; 36(3): 156.     CrossRef
  • 5,009 View
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  • 12 Crossref
Inter-arm Differences in Simultaneous Blood Pressure Measurements in Ambulatory Patients without Cardiovascular Diseases
Kyoung Bog Kim, Mi Kyeong Oh, Haa Gyoung Kim, Ji Hoon Ki, Soo Hee Lee, Su Min Kim
Korean J Fam Med 2013;34(2):98-106.   Published online March 20, 2013
DOI: https://doi.org/10.4082/kjfm.2013.34.2.98
Background

It has traditionally been known that there is normally a difference in blood pressure (BP) between the two arms; there is at least 20 mm Hg difference in the systolic blood pressure (SBP) and 10 mm Hg difference in the diastolic blood pressure (DBP). However, recent epidemiologic studies have shown that there are between-arm differences of < 5 mm Hg in simultaneous BP measurements. The purposes of this study is to examine whether there are between-arm differences in simultaneous BP measurements obtained from ambulatory patients without cardiovascular diseases and to identify the factors associated these differences.

Methods

We examined 464 patients who visited the outpatient clinic of Gangneung Asan Hospital clinical department. For the current analysis, we excluded patients with ischemic heart disease, stroke, arrhythmia, congestive heart failure, or hyperthyroidism. Simultaneous BP measurements were obtained using the Omron MX3 BP monitor in both arms. The inter-arm difference (IAD) in BP was expressed as the relative difference (right-arm BP [R] minus left-arm BP [L]: R - L) and the absolute difference (|R - L|).

Results

The mean absolute IAD in SBP and DBP were 3.19 ± 2.38 and 2.41 ± 1.59 mm Hg, respectively, in men and 2.61 ± 2.18 and 2.25 ± 2.01 mm Hg, respectively, in women. In men, there were 83.8% of patients with the IAD in SBP of ≤ 6 mm Hg, 98.1% with the IAD in SBP of ≤ 10 mm Hg, 96.5% with the IAD in DBP of ≤ 6 mm Hg and 0% with the IAD in DBP of > 10 mm Hg. In women, 89.6% of patients had IAD in SBP of ≤ 6 mm Hg, 92.1% with IAD in DBP of ≤ 6 mm Hg, and 0% with IAD in SBP of > 10 mm Hg or IAD in DBP of > 10 mm Hg. Gangneung Asan Hospital clinical series of patients showed that the absolute IAD in SBP had a significant correlation with cardiovascular risk factors such as the 10-year Framingham cardiac risk scores and higher BP in men and higher BP in women. However, the absolute IAD in SBP and DBP had no significant correlation with the age, obesity, smoking, drinking, hyperlipidemia, diabetes, metabolic syndrome, and renal function.

Conclusion

Our results showed that there were no significant between-arm differences in simultaneous BP measurements. It was also shown that most of the ambulatory patients without cardiovascular diseases had an IAD in SBP of < 10 mm Hg and an IAD in DBP of < 6 mm Hg.

Citations

Citations to this article as recorded by  
  • Unilateral Exercise and Bilateral Vascular Health in Female Tennis Players and Active Controls
    Chanhtel E. Thongphok, Abena O. Gyampo, Elisa Fioraso, Anneli O. Ramolins, Elianna G. Hills, Claire E. Coates, Stephen J. Ives
    Sports.2025; 13(4): 107.     CrossRef
  • Simultaneously measured inter-arm blood pressure difference is not associated with pulse wave velocity in a clinical dataset of at-risk hypertensive patients
    Janis M. Nolde, Leslie Marisol Lugo-Gavidia, Dennis Kannenkeril, Justine Chan, Sandi Robinson, Ancy Jose, Anu Joyson, Luca Schlaich, Revathy Carnagarin, Omar Azzam, Márcio Galindo Kiuchi, Markus P. Schlaich
    Journal of Human Hypertension.2022; 36(9): 811.     CrossRef
  • A new approach for daily life Blood-Pressure estimation using smart watch
    Jiayu He, Jianlin Ou, An He, Lin Shu, Tao Liu, Ruowen Qu, Xiangmin Xu, Zhuoming Chen, Yifeng Yan
    Biomedical Signal Processing and Control.2022; 75: 103616.     CrossRef
  • Prevalence of inter-arm blood pressure difference among young healthy adults: Results from a large cross-sectional study on 3235 participants
    Rawand Abdulrahman Essa, Sirwan Khalid Ahmed
    Annals of Medicine & Surgery.2022;[Epub]     CrossRef
  • Characteristics of Inter-Arm Difference in Blood Pressure in Acute Aortic Dissection
    Nozomi Sasamoto, Koichi Akutsu, Takeshi Yamamoto, Toshiaki Otsuka, Hideto Sangen, Hiroshi Hayashi, Hiroshige Murata, Hideki Miyachi, Yusuke Hosokawa, Shuhei Tara, Yukichi Tokita, Satoshi Miyata, Tetsuro Morota, Takashi Nitta, Wataru Shimizu
    Journal of Nippon Medical School.2021; 88(5): 467.     CrossRef
  • The Future Alert of Inter-Arm Blood Pressure Difference Among Young Healthy Population: A Cross-Sectional Study. (Preprint)
    Rawand Essa, Sirwan K. Ahmed, Sanaa Hassan Abdul-Sahib, Rozhgar Mohammed Qadir, Zhala Khdir Miire
    Journal of Medical Internet Research.2020;[Epub]     CrossRef
  • Inter‐arm systolic blood pressure dependence on hand dominance
    Harvey N. Mayrovitz
    Clinical Physiology and Functional Imaging.2019; 39(1): 35.     CrossRef
  • Inter-arm Systolic Blood Pressure Difference in Physically Active, Adult Subjects
    Daniel Neunhäuserer, Andrea Gasperetti, Sara Ortolan, Francesca Battista, Pietro Pettenella, Marco Zaccaria, Marco Bergamin, Andrea Ermolao
    High Blood Pressure & Cardiovascular Prevention.2018; 25(3): 303.     CrossRef
  • The interarm blood pressure difference: Do we know enough yet?
    Christopher E. Clark
    The Journal of Clinical Hypertension.2017; 19(5): 462.     CrossRef
  • Monitorización de la presión arterial en esfuerzo. ¿Brazo dominante, no dominante o ambos? / Monitoring of the Arterial Pressure in Effort. Dominant, not Dominant Arm or Both?
    C.E. Polo-Portes, M.J. Del Castillo-Campos, J.J. Ramos-Álvarez, M.T. Lara-Hernández
    Revista Internacional de Medicina y Ciencias de la Actividad Física y del Deporte.2017;[Epub]     CrossRef
  • Interarm Difference in Systolic Blood Pressure in Different Ethnic Groups and Relationship to the “White Coat Effect”: A Cross-Sectional Study
    Claire Lorraine Schwartz, Christopher Clark, Constantinos Koshiaris, Paramjit S Gill, Shelia M Greenfield, Sayeed M Haque, Gurdip Heer, Amanpreet Johal, Ramandeep Kaur, Jonathan Mant, Una Martin, Mohamed A Mohammed, Sally Wood, Richard J McManus
    American Journal of Hypertension.2017; 30(9): 884.     CrossRef
  • Interarm blood pressure difference in a post-stroke population
    Eva Gaynor, Linda Brewer, Lisa Mellon, Patricia Hall, Frances Horgan, Emer Shelley, Eamonn Dolan, Anne Hickey, Kathleen Bennett, David J. Williams
    Journal of the American Society of Hypertension.2017; 11(9): 565.     CrossRef
  • Prevalence of systolic inter-arm differences in blood pressure for different primary care populations: systematic review and meta-analysis
    Christopher E Clark, Rod S Taylor, Angela C Shore, John L Campbell
    British Journal of General Practice.2016; 66(652): e838.     CrossRef
  • Gender differences in the relationship between adiposity and systolic inter-arm blood pressure difference in Korea adults
    Gwang-Seok Kim
    Journal of the Korea Society of Computer and Information.2016; 21(11): 113.     CrossRef
  • The Relationship Between the Metabolic Syndrome and Systolic Inter-Arm Systolic Blood Pressure Difference in Korean Adults
    Hyun Yoon, Seong Woo Choi, Jong Park, So Yeon Ryu, Mi Ah Han, Gwang Seok Kim, Sung Gil Kim, Hye Jong Oh, Cheol Won Choi
    Metabolic Syndrome and Related Disorders.2015; 13(8): 329.     CrossRef
  • Association of Inter-arm Blood Pressure Difference with Atherosclerosis in Patients without Cardiovascular Diseases
    Young-Jin Tak, Yun-Jin Kim, Sang-Yeoup Lee, Jeong-Gyu Lee, Dong-Wook Jeong, Yu-Hyeon Yi, Young-Hye Cho, Eun-Jung Choi, Kyung-Jee Nam, Hye-Rim Hwang
    Journal of the Korean Society of Hypertension.2013; 19(3): 71.     CrossRef
  • 4,830 View
  • 33 Download
  • 16 Web of Science
  • 16 Crossref
Background

According to the current guidelines for blood pressure monitoring, clinicians are recommended to measure blood pressure by completely exposing the upper arm. However, it is a common practice that blood pressure is measured with the cuff placed over the sleeve or with the sleeve rolled up. We therefore conducted this study to examine whether there are any differences in blood pressure measurements among the three different settings: the sleeve group, the rolled sleeve group, and the bare arm group.

Methods

We conducted the current study in 141 male and female adult patients who visited our clinical department. In these patients, we took repeatedly blood pressure measurements using the same automatic oscillometric device on three different settings. Then, we analyzed the results with the use of randomized block design analysis of variance.

Results

The mean values of systolic blood pressure (SBP) between the first reading and those of the second reading were 128.5 ± 10.6 mm Hg in the sleeve group, 128.3 ± 10.8 mm Hg in the rolled sleeve group, and 128.3 ± 10.7 mm Hg in the bare arm group. These results indicate that there were no significant differences among the three groups (P = 0.32). In addition, the mean values of diastolic blood pressure (DBP) between the first reading and those of the second reading were 80.7 ± 6.1 mm Hg in the sleeve group, 80.7 ± 6.1 mm Hg in the rolled sleeve group, and 80.6 ± 5.9 mm Hg in the bare arm group. These results indicate that there were no significant differences among the three groups (P = 0.77). In addition, based on the age, sex, past or current history of hypertension or diabetes mellitus, the thickness of sleeve, weight, a drinking history, and a smoking history, there were no significant differences in SBP and DBP among the three groups.

Conclusion

There were no significant differences in blood pressure measurements between the three different settings (the sleeve group, the rolled sleeve group, and the bare arm group).

Citations

Citations to this article as recorded by  
  • A Survey on Blood Pressure Measurement Technologies: Addressing Potential Sources of Bias
    Seyedeh Somayyeh Mousavi, Matthew A. Reyna, Gari D. Clifford, Reza Sameni
    Sensors.2024; 24(6): 1730.     CrossRef
  • The Effect of Clothes on Blood Pressure Measurement in Normotensive and Hypertensive Subjects in a Real-Life Setting
    Edwin Castillo Velarde, Jorge Roca-Sánchez-Moreno, Alison Núñez Muñoz, Alessandra Guillen Rivera, Mary Hidalgo Babilonia, Jherson García Meneses, Lisseth Mamani Turpo, Willian Cepeda Horna
    Kidney and Blood Pressure Research.2024; : 1.     CrossRef
  • Comparison of blood pressure measurements on the bare and sleeved arms – what does it uncover?
    Rotem Tal-Ben Ishay, Adi Leiba, Vladimir Rappoprt, Avital Angel-Korman, Zeev Katzir
    Blood Pressure Monitoring.2023;[Epub]     CrossRef
  • Sources of automatic office blood pressure measurement error: a systematic review
    Jian Liu, Yumin Li, Jianqing Li, Dingchang Zheng, Chengyu Liu
    Physiological Measurement.2022; 43(9): 09TR02.     CrossRef
  • No effect of sleeved arms on the accuracy of blood pressure measurement
    Ya Li, Yi Li, Fang Li, Demin Liu, Yanan Zhang, Xiaoran Cui, Wei Cui
    Internal Medicine Journal.2021; 51(12): 2087.     CrossRef
  • Blood pressure measurements on a bare arm, over a sleeve or below a rolled-up sleeve: a systematic review and meta-analysis
    David Seguret, Danaé Gamelon, Caroline Dourmap, Olivier Steichen
    Journal of Hypertension.2020; 38(9): 1650.     CrossRef
  • The Reliability of Noninvasive Blood Pressure Measurement Through Layers of Autumn/Winter Clothing: A Prospective Study
    Przemysław Wołoszyn, Ignacy Baumberg, David Baker
    Wilderness & Environmental Medicine.2019; 30(3): 227.     CrossRef
  • 3,653 View
  • 38 Download
  • 7 Crossref

Review

Secondary Hypertension.
Mi Kyeong Oh
Korean J Fam Med 2010;31(6):420-429.   Published online June 20, 2010
DOI: https://doi.org/10.4082/kjfm.2010.31.6.420
Hypertension is a major risk factor for the development of cardiovascular disease. The prevalence of secondary hypertension, 10% is known as a common cause of resistant hypertension. Development of diagnostic technology and the aging is likely to be increased of the prevalence. Secondary hypertension, if it is not appropriate etiologic treatment may sometimes be fatal, as well as to the proper treatment be treatable or curable hypertension. Secondary causes of hypertension include a greater prevalence of obstructive sleep apnea, renal parenchymal disease, renovascular disease and primary aldosteronism. Uncommon secondary causes include pheochromocytoma, Cushing's syndrome, hyperparathyroidism and thyroid disease. Clinical clues for secondary hypertension is onset of hypertension in persons younger than age 20 or older than age 50 without family history of hypertension, poor response to therapy, worsening of control in previously stable hypertensive patient, markedly elevated blood pressure or hypertension with severe end-organ damage, presence of abdominal bruit (renal artery stenosis), moon face and abdominal striae (Cushing's syndrome), paroxysmal headaches and palpitations (pheochromocytoma), pronounced hypokalemia due to low dose diuretic therapy (primary aldosteronism), acute renal failure or hypokalemia after initiation of angiotensin converting enzyme inhibitors or angiotensin II receptor blocker (renal artery stenosis), hypercalcemia (hyperparathyroidism), snoring and daytime somnolence (obstructive sleep apnea). A combination of a good history and physical examination, astute observation, and accurate interpretation of available data usually are helpful in the diagnosis of a specific causation. This article provides an overview of the range of secondary hypertension, including key clinical features, appropriate diagnostic approach and treatment for primary physician.
  • 2,360 View
  • 88 Download

Case Report

A Case of Successful Correction of Subclavian Steal Syndrome by Percutaneus Transluminal Angioplasty with Stenting Who Found Incidentally Significant Interarm Blood Pressure Difference.
Won Back Kim, Mi Kyeong Oh, Soo Hee Lee, Jin Roh, Haa Gyoung Kim, Jin Young Kim, Sang Sig Cheong, Seung Mun Jung
Korean J Fam Med 2009;30(12):979-984.   Published online December 20, 2009
DOI: https://doi.org/10.4082/kjfm.2009.30.12.979
A case of successful correction of subclavian steal syndrome by percutaneous transluminal angioplasty with stenting in a male patient who found incidentally signifi cant interarm blood pressure difference. Small difference in blood pressure (BP) between two arms is a relatively common. Significant interarm BP difference is a potential marker of peripheral vascular disease such as subclavian artery stenosis and a predictor of cardiovascular disease. The subclavian steal syndrome is a condition that results from stenosis of subclavian artery proximal to the vertebral artery. The resulting symptoms are vertebrobasilar insuffi ciency symptoms due to reversal of blood fl ow from the contralateral vertebral and basilar artery into the ipsilateral upper extremity vessels and arm ischemic symptoms. Stenotic lesion of subclavian artery has traditionally been treated surgically. However recent trends are undergoing a paradigm shift from open surgery to endovascular approach. We report a patient with subclavian steal syndrome who found incidentally 35 mmHg interarm systolic BP difference. It was successfully treated by percutaneus transradial angioplasty with stenting on stenotic lesion of the subclavian artery.

Citations

Citations to this article as recorded by  
  • Duplex Sonography in Subclavian Steal Syndrome Treated by Stent Insertion
    Minho Han
    The Korean Journal of Clinical Laboratory Science.2018; 50(3): 370.     CrossRef
  • The Role of Duplex Sonography in Right Subclavian Double Steal Syndrome
    Minho Han, Bok Hee Jin, Hyo Suk Nam
    The Korean Journal of Clinical Laboratory Science.2017; 49(3): 316.     CrossRef
  • Inter-arm Differences in Simultaneous Blood Pressure Measurements in Ambulatory Patients without Cardiovascular Diseases
    Kyoung Bog Kim, Mi Kyeong Oh, Haa Gyoung Kim, Ji Hoon Ki, Soo Hee Lee, Su Min Kim
    Korean Journal of Family Medicine.2013; 34(2): 98.     CrossRef
  • 2,209 View
  • 11 Download
  • 3 Crossref

Review

Clinical Application of Family-Centered Health Care.
Jong Sung Kim, Mi Kyeong Oh, Joo Sung Park
Korean J Fam Med 2009;30(6):405-414.   Published online June 20, 2009
DOI: https://doi.org/10.4082/kjfm.2009.30.6.405
For practicing comprehensive approach to health problems, family physicians should see both biomedical aspects and psychosocial aspects of each patient at the same time. Family physicians can hypothesize and intervene effectively the psychosocial aspects of patients through family-centered health care. Genogram, family life cycle, family's resources for stressful life events, and adaptability and cohesiveness of patients' family are the four eyes of family physicians, those enable family physicians to see the family of patients in their health care practice. Family-centered health care in family practice can be achieved by applications of family-related questions to routine health care practice, approaches to the family dynamics in patients with red fl ags, and family conferences for inpatients and patients with more diffi cult problems. Family-centered health care is the core practice of comprehensive approach to health problems and an important identity of family medicine.

Citations

Citations to this article as recorded by  
  • Relationship between Family Adaptability, Cohesion and Adolescent Problem Behaviors: Curvilinearity of Circumplex Model
    Ju Youn Joh, Sun Kim, Jun Li Park, Yeon Pyo Kim
    Korean Journal of Family Medicine.2013; 34(3): 169.     CrossRef
  • 2,067 View
  • 23 Download
  • 1 Crossref

Original Articles

Infective Endocarditis Not Easily Diagnosed in Primary Care.
Song yi Paek, Doo Young Lee, Mi Kyeong Oh, Sang Sig Cheong
J Korean Acad Fam Med 2008;29(6):431-437.   Published online June 10, 2008
Background
Despite the use of antibiotics and cardiac surgery, infective endocarditis, remains a life-threatening disease. Unfortunately, diagnosis and treatment may be delayed. This is due, in part, to the vague and, at times, baffling clinical picture of this disease and to the frequency with which antibiotics were administered prior to obtaining a microbiological diagnosis. We conducted this study to improve the suspicion index from difficult diagnostic process of this serious disease. Methods: We retrospectively reviewed the medical records of 39 patients admitted to the Gangneung Asan Hospital in Gangwon-do with infective endocarditis from December 1996 to July 2004. We evaluated initial chief complaints and presumed diagnosis on first visit to medical care facilities, duration of referral from primary care to our hospital, the time period to confirm the diagnosis, treatment modality, and survival rate. Results: Among the total, 23 out of 39 patients fulfilled the criteria for definite infective endocarditis, whereas the others (16 patients) were for possible group in Duke criteria. In 79.5%, infective endocarditis was the first clinical presentation without medical history of any cardiac disease. Most frequent initial presenting symptoms and signs were fever and chills (56.4%), abnormal neurologic deficit (12.8%), and myalgia (7.6%). The most common initial diagnosis at first medical facilities was common cold. The mean duration of referral from primary care to our hospital was 9.5 days. The mean duration of symptoms before the definite diagnosis was 20.3 days. The most frequent etiologic microorganisms were streptococcus and staphylococcus. Blood culture negative infective endocarditis was found in 35.9% of cases. Almost all patients were treated with 3rd generation cephalosporins. Among the total, 71.6% patients were treated with medical treatment only, and 28.2% patients required surgical intervention. The mortality rate was 20.5% with the major cause of death being sepsis. Conclusion: Since the symptoms and signs of infective endocarditis are nonspecific, it is difficult to suspect and reach to correct diagnosis of infective endocarditis in primary care, requiring prolonged duration of 3 weeks to reach diagnosis. The consequences can result in higher rate of systemic complications and mortality. (J Korean Acad Fam Med 2008;29:431-437)
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Cardio-thoracic Ratio (CTR) for Detection of Left Ventricular Hypertrophy (LVH) in Elderly People.
Sung Hoon Kim, Yun Jeong Shin, Hee Suk Kang, Hai Gyung Yoon, Mi Kyeong Oh, Sang Sig Cheong
J Korean Acad Fam Med 2007;28(9):690-697.   Published online September 10, 2007
Background
Left ventricular hypertrophy (LVH) is closely related with a high death rate, rhythmia, ischemic heart disease, stroke and sudden death. It is known that the prognosis becomes better as LVH regresses. Therefore, it is important to diagnose it correctly with ease in primary care. The authors evaluated the most standard cardio-thoracic ratio (CTR) with respect to LVH oriented towards elderly people whose body habitus changed over time as they had become older, and evaluated the factors which affect the rate of diagnosis including sensitivity and specificity. Methods: A total of 231 subjects over 60 years of age who visited a general hospital health promotion center from March 1997 to August 2003, underwent echocardiography and identified not to have heart disease were selected. LV (left vetricular) mass was measured through echocardiography. LV mass was divided by 2.7 times of height (m) by Deveruex's method, and 49.1 g/m2.7 for men and 46.7 g/m2.7 for women were set to be standards of LVH. CTR was obtained by dividing the maximum transverse diameter of the heart by maximum transverse diameter of thorax on chest PA. Results: CTR was observed on the basis of 0.45, 0.5, 0.55, and the agreement was highest of 0.5 for men and 0.45 for women. However, considering the sensitivity, the specificity, and the positive predictive value, it was thought to be most proper to be set at 0.5 was be standard for both men and women. When diagnosing LVH through chest PA, if 0.5 was set to be standard, false positive become high in women, false negative became high as height increased, and false negative became high as body mass index (BMI) increased. The smoking group showed higher false negative compared to the non- smoking group, and the false negative was higher as the level of hemoglobin increased. Conclusion: When diagnosing LVH through CTR in elderly people, it was appropriate to set 0.5 as a standard, but it is necessary to consider sex, body habitus, BMI, smoking and the level of hemoglobin. (J Korean Acad Fam Med 2007;28:690-697)
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Relationship of Left Ventricular Mass to Obesity in Normotensive Adults.
Sun Woo Yang, Dong Sig Yoo, Eun Jin Choi, Yun Jung Shin, Doo Young Lee, Sang Sig Cheong, Jung Song Kim, Wong Seb Park, Mi Kyeong Oh
J Korean Acad Fam Med 2007;28(4):249-255.   Published online April 10, 2007
Background
Left ventricular hypertrophy (LVH) has been shown to be an independent risk factor for cardiovascular morbidity and mortality. The combination of hypertension and obesity are well known to act as risk factors of left ventricular hypertrophy in a number of studies, but it is unclear whether obesity itself stimulates LVH independently. Therefore, we investigated the relationship of left ventricular mass to body size in normotensive adults. Methods: A population sample of 240 normotensive (systolic BP <140 mmHg and diastolic BP <90 mmHg) adults (139 men and 101 women) was examined by echocardiography. We excluded adults with history of hypertension, thyroid diseases, diabetes mellitus and other cardiac diseases. Left ventricular mass normalized for height2.7 was used in the analyses and left ventricular hypertrophy was defined as a value of 50 g/m2.7 men or 47 g/m2.7 in women. Results: Left ventricular mass significantly and positively correlated with body mass index. On univariate correlation analysis after adjusting for age, the body mass index was associated with LV mass/height2.7 (LVMI: Left Ventricular Mass Index) in males and body mass index, waist circumference, hip circumference and waist/hip circumference ratio were associated with LVMI in females. Left ventricular hypertrophy was more frequent in overweight (33.3%) and obese (39.4%) groups than in lean group (15.9%). Conclusion: Left ventricular mass was strongly related to obesity in normotensive adults, especially in females. Obesity may be an independent risk factor for left ventricular hypertrophy. (J Korean Acad Fam Med 2007;28:249- 255)
  • 1,253 View
  • 12 Download

Review

Postexposure Prophylaxis of Infectious Disease.
Mi Kyeong Oh
J Korean Acad Fam Med 2006;27(12):955-966.   Published online December 10, 2006
  • 1,347 View
  • 25 Download

Original Articles

Electrocardiogram as a Diagnostic Method for Left Ventricular Hypertrophy.
Yun Jeong Shin, Eun Jin Choi, Dong Sik Yu, Doo Young Lee, Mi Kyeong Oh, Sang Sig Cheong, Woong Sub Park
J Korean Acad Fam Med 2005;26(9):551-560.   Published online September 10, 2005
Background
: The purpose of this study was to examine the sensitivity and specificity of ECG as a tool for detecting echocardiographically defined LVH in a population-based sample and to examine the impact of a variety of factors that affect the sensitivity and specificity of ECG for detection of LVH.

Methods : A total of 1,130 subjects who received a thorough medical checkup for cardiologic department voluntarily were selected. The subjects were examined using M-mode echocardiography and standard 12-lead ECG. The x2 test was used to test for differences in sensitivity and specificity of ECG for echocardiographically defined LVH. Cochran-Mantel-Haenszel statistic was used to adjust for sex, age, and obesity and to test the association between cigarette smoking, amount of alcohol, exercise, hypertension, diabetes mellitus (DM) and sensitivity and specificity of ECG.

Results : Echocardiographic LVH was detected in 434 (38.4%) and electrocardiographic features of LVH were present in 146 (12.9%). ECG for diagnosis of LVH showed sensitivity of 20.0%, specificity of 91.5%, and diagnostic accuracy of 64.1%. Sensitivity of ECG for LVH was higher in persons with obesity (P=.04) or hypertension (P=.04). Specificity of ECG for LVH was lower in persons with hypertension (P=.003).

Conclusion : ECG has a low sensitivity and a high specificity for echocardiographically defined LVH. Attention must be paid to carefully interpret ECG for diagnosis of LVH in persons with obesity or hypertension, because the rate of false positives and negatives can be increased.
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Change of Antibiotic Sensitivities to Causative Organisms of Urinary Tract Infection in Out Patients 2 years Before and After the Separation of Prescription and Dispensing Medicines.
Eun Jin Choi, Mi Kyeong Oh, Seoun Woo Yang, Dong Sik You, Yeun Jung Sin, Sang Sig Cheong, Jong Sung Kim
J Korean Acad Fam Med 2005;26(2):88-95.   Published online February 10, 2005
Background
: The overuse and misuse of antimicrobial agents and their resultant emergence of resistant microorganisms have made choices regarding antimicrobial therapy more difficult. Therefore, a new system that separated prescribing and dispensing medicine began on July 1, 1997 to prevent overuse and misuse of medicine. We studied to evaluate changes of antibiotic sensitivities to causative microorganisms of urinary tract infection 2 years before and after the new medical system.

Methods : During each 2 years before and after the new medical system, we analyzed antibiotic sensitivities of causative microorganisms for urinary tract infection among the 447 outpatients who visited a hospital in GangNeung. The diagnosis of urinary tract infection was based on greater than 105 CFU (Colony For Unit) per ml urine.

Results : The most common pathogenic microorganisms as E.coli (76.5%), followed by Klebsiella pneumoniae (5.1%), and Proteus mirabilis (3.6%) in urine culture. A first generation cephalosporin, cephalothin, against E.coli, had more significant sensitivity after the introduction of the new medical system (52.6%) than before (33.9%), especially in the 8th decade (P=0.023) and in females (P<0.001). Also, trimethoprim/sulfamethoxazole against E.coli showed signifcant improving sensitivity (P=0.025).

Conclusion : There was little change of antibiotic sensitivity of urinary tract infection in outpatients before and after the new medical system in cephalothin and trimethoprim/sulfamethoxazole against E.coli. The change of antibiotic sensitivities will require further observation for a longer term after the introduction of the new medical system.
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Case Report

One Case of Systemic Lupus Erythematosus with Chief Complaint of Xerostomia and Abnormal Liver Function.
Je Wook Yeon, Song Yee Baek, Ho Woong Cho, Youn Jeong Shin, Dong Sik U, Eun Jin Choi, Mi Kyeong Oh
J Korean Acad Fam Med 2004;25(6):475-480.   Published online June 10, 2004
Dry mouth is a common symptom in over middle- aged women. Xerostomia itself can be caused by multifactorial etiolgy. Dry mouth may occur with the use of medications, as a complication of connective tissue and autoimmune disease, such as Sjogren's syndrome or sicca syndrome, with radiation therapy to the head and neck or diabetes mellitus, or with a number of other condition. Even stress and anxiety can lead to a dry mouth. Also, Abnormal liver function is associated with drugs, viral infection, alcohol, obesity, autoimmne disease and a number of other disease. A 41-year-old women complaining of xerostomia and known abnormal liver fuction since 1 year was admitted to our medical examination center. In this case, Final diagnosis was systemic lupus erythematosus with autoimmune hepatitis and secondary Sjogren's syndrome through characteristic clinical finding, liver biopsy, positive Schirmer's test, salivary gland biopsy, and salivary scintigraphy. The various immunosuppresant medication has taken and then liver function indices and clinical symptoms were improved.
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Original Articles

The Difference of Health Status between Urban and Rural Elderly.
Jin Yong Jun, Sang A Kim, Woong Sub Park, Mi Kyeong Oh
J Korean Acad Fam Med 2002;23(11):1348-1358.   Published online November 10, 2002
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Relationship between Carcinoembryonic Antigen (CEA) and Pulmonary Function in Middle-aged Male Smokers.
Byoung Joon Moon, Dong Jin Lee, Kyeong Duk Ko, Sun Woo Yang, Kyeong Su Chun, Mi Kyeong Oh
J Korean Acad Fam Med 2002;23(7):925-933.   Published online July 10, 2002
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Review

Diagnosis and treatment of urinary tract infection in adults.
Mi Kyeong Oh
J Korean Acad Fam Med 2001;22(12):1707-1716.   Published online December 1, 2001
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Original Articles
Prevalence of thyroid diseases among adult for health check-up in a Youngdong area of Kwangwon province.
Mi Kyeong Oh, Kung Soo Cheon, Seung Mun Jung, Dae Sik Ryu, Man Soo Park, Sang Sig Cheong, Jong Sung Kim, Byoung Gang Park
J Korean Acad Fam Med 2001;22(9):1363-1374.   Published online September 1, 2001
Background
: Thyroid diseases is common in adult and frequently has significant clinical consequences. But, Prevalence have not been accurately estimated before performance of sensitive TSH and high resolution ultrasound devices on thyroid gland in practice. The objective of the study was to obstain prevalance rate of thyroid dysfunciton and structural abnormality by sensitive TSH, Free T4 and high resolution ultrasound.

Methods : The subjects were 10,543(5,638 male and 4,815 female) individuals who visited a health care center of a general hospital in Kangnung city during the period of Jun. 1st, 1997 through May 31st, 2000. For thyroid dysfunction, serum TSH(Thyroid Stimulation Hormone)and Free T4 concentration of those were measured by RIA or IRMA. During the period of Dec. 1St, 1997 through May 25th, 1998, 1,316 individuals were examined by radiology specialists using high resolution ultrasonography with 7.5 MHz linear array. Consequently 21 patients who showed thyroid nodule were performed ultrasound-guided fine needle aspiration. Accordingly medical records containing results of physical examination made by 3 specialists in family medicine before thyroid ultrasonography were investigated in association with other diagnostic modalities.

Results : The measurements of thyroid function revealed that 10,090(96.5%) were normal, 240(2.3%) low(below 0.39 mU/L) and 123(1.2%) high (above 5.1 mU/l) in TSH. In terms of prevalence rate per 1,000 population, 15.2 cases were with subclinical hyperthyroidism, and 9.0 cases with subclinical hypothyroidism, 7.7 cases with hyperthyroidism and 3.3 cases with hypothyroidism. Among 94 individuals(7.1%) with structural abnormality on thyroid gland by ultrasonography, 60(4.6%) showed solitary solid nodule, 12(0.9%) multiple solid nodules, 18(1.4%) cystic nodules and 3(0.3%) diffuse parenchymal lesions. Physical examination found only 13.3% of 91 nodules found by high-resolution ultrasongraphy, and nodules as large as above 1.0 cm in size were palpable only in 22.2%. 21 Of 91 thyroid nodules was received ultrasound-guided FNA and 4(19%) were found to have malignant nodules.

Conclusion : The study results showed the relatively high rate of thyroid diseases among general population, with the prevalence rate of thyroid dysfunction 3.6%, thyroid nodule 6.9%, malignant incidentaloma among thyroid nodules 4.4%. Physical examination was relative ineffective in detection for thyroid nodules in routine health examinations.
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Influence of alcoholic's insight on their abstinent outcomes for one year after discharge.
Jong Sung Kim, Byoung Kang Park, Young Chae Cho, Mi Kyeong Oh, Gap Jung Kim, Jang Kyun Oh
J Korean Acad Fam Med 2001;22(7):1052-1066.   Published online July 1, 2001
Background
: This study was intended to present the importance of insight status concerning the abstinence of alcoholics.

Methods : The 214 subjects, who participated in insight-improving programs during hospitalization in an alcohol treatment center, were followed up for their abstinent status during the 12month period after discharge, The relation between their abstinence results and insight status was investigated. To find out the influence of other factors upon abstinence. stepwise multiple regression was performed over variables including disease severity, sociodemographic, therapeutic and familial features.

Results : The 73 individuals (34.1%) had 'no remission', 110 (51.4%) 'early full remission', and 31 (14.5%) 'sustained full remission'. The insight degree was significantly correlated with both 'initial consecutive months of sobriety'(IMS) after discharge and 'total months of sobriety'(TMS) during the follow-up. The 153 subjects (71.5%) relapsed within four months after discharge, and the rage of continuous abstinence at each month differed significantly among three insight groups. On the inter-group shifts during hospitalization, the abstinent months were greater in the group whose insight changed from 'poor-' to 'good-insight' than the one from 'fair-' to 'good-insight'. By stepwise multiple regression analysis, the higher insight scores, older age and shorter hospital days, in a decreasing order of association, the longer IMS and TMS, while absence of religion and lower MAST scores was associated only with IMS, with their overall R2 value of 18.5% and 20.8%, respectively.

Conclusion : The insight degree was related to the length of abstinence and thus it is necessary to develop insight-improving programs which can be of help to recovering patients.
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A seroepidemiologic and it's 1 year follow up study on anti HAV IgG for college students living in dormitory.
Mi Kyeong Oh
J Korean Acad Fam Med 2001;22(5):647-655.   Published online May 1, 2001
Background
: In Korea, Improvements of standards of hygiene, sanitation and water supply led to a significant reduction in the endemicity of HAV infection, so that hepatitis A outbreaks have shifted from children to adolescents and young adults. Hepatitis A infection becomes more symptomatic with increasing age. We studied Hepatitis A antibody prevalence in college students, who start living a active life in a community. Hepatitis A infection is primarily by the fecal-oral route transmitted disease by either person-to-person contact or ingestion or contaminated food or water. So, We studied follow up prevalance of anti-HAV IgG in college students who were living together in dormitory during 1 year.

Methods : The 668 serum samples were obtained from college students living in dormitory. Kangung National University during the period of May 2nd through 5th, 1999. For follow up study, the 158 serum samples were obtained from this group during the period of May, 2000. Anti-HAV IgG was measured by HAVAB radioimmunoassy.

Results : The overall seroprevalence rate of anti-HAV IgG 16.3% in 1999. According to age, the anti-HAV IgG positive rate was increase with age, 10.5% in 18 years, 12.4% in 19 years, 15.9% in 20 years, 22.5% in 21 years, 27.9% in 22-26 years. The seroprevalence of anti-HAV IgG was increase with year of university entrance, but not different with sex, department of college and number of family. The anti-HAV IgG positive rate in urban group(14.7%) of native place was lower than in rural group(21.5%). Seroconversion rate of negative anti-HAV IgG was only 1.3% during I year.

Conclusion : This study showed that the seroprevalence of hepatitis A virus was a dramtic drop among adolsecent and young adulthood in korea. Natural acquisition of HAV antibody rarely occurs during 1 year in living condition such as dormitory.
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The Clinical significance of HBV markers in chronic HBsAg carrier: Titers of HBsAg, and HBeAg, and presence or absence of HBeAg and HBV-DNA.
Mi Kyeong Oh, Dong Jin Lee, Joo Hyun Han, Kung Soo Chon, Jong Sung Kim, Kung Suk Won
J Korean Acad Fam Med 2000;21(10):1307-1316.   Published online October 1, 2000
Background
: All individuals chronically positive for HBsAg are not always complicated by advanced liver diseases and have various differences in their clinical progression. In an attempt to find out the factors determining clinical progression, comparative analysis was made among four groups (asymptomatic, chronic hepatitis, liver cirrhosis and hepatocellular group) according to the titers of HBeAg and HBeAg, and the presence or absence of HBeAg and HBV-DNA.

Methods : This study included 198 males and 96 females who visited Asan foundation Kangnung Hospital from Sep. 1, 1996 to May 31, 1998 and the subjects were HBsAg-positive for at least six months. They were classified into four groups on the basis of their worst results after CBC, LFT, and abdominal ultrasonography carried out on two occasions at least at three-month intervals. For confirmation of hepatoma abdominal CT and hepatic angiography were performed. Among the four groups compared were the mean titers of HBsAg and HBeAg, and positive rate of HBeAg and HBV-DNA.

Results : A total of 294 subjects was diagnosed as having no symptoms in 169(57%), chronic hepatitis in 71 (24.1%), liver cirrhosis in 41 (13.9%), and hepatoma in 13 subjects (4.4%). The more advanced in age (p<0.01) and sexual preference of males (p<0.05) were found to be associated with worse liver conditions. The Asymptomatic Group showed lower titers of HBsAg (p<0.01) and HBV-DNA (p<0.01). In the case of subjects without HBeAg, the presence of HBV-DNA was significantly linked to chronic hepatitis and liver cirrhosis (p<0.01). Based on age by multiple regression, the group of less than 29 years of age had higher titer of HBeAg as determinant factor for clinical progression, 30-39 years of age the presence of HBV-DNA, 40-49 years of age the presence of HBeAg, the presence of HBeAg and male, the group of more than 50 years of age had higher titers of HBeAg, the presence of HBV-DNA, and higher titers of HBsAg.

Conclusion : The present study revealed that clinical progression depended upon the titers of HBsAg and HBeAg, and the presence or absence of HBeAg and HBV-NDA in the same age group, and sexual preference for males as well as older age counted for clinical worsening of chronic HBsAg-positive subjects.
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Seroprevalence of hepatitis B virus markers among adult in a Youngdong area of Kwangwon Province.
Mi Kyeong Oh, Jong Sung Kim, Yong Bin Lee, Joo Hyun Han
J Korean Acad Fam Med 2000;21(1):91-99.   Published online January 1, 2000
Background
: Hepatitis B is a leading cause of chronic hepatitis, cirrhosis, and hepatocelluar carcinoma. It is a well-known fact that Korea is one of the hyperendemic areas of Hepatitis B virus among East Asian countries. Many pnst reports have shown that positive rate of HBsAg in Korea was about 6-14%. But precise data for Yongdong area of Kwangwon Province in Korea was lacking. Here authors report on the prevalence of viral markers of hepatitis B among adults in this area.

Methods : Sera were collected from 7469 residents in Yongdong area of Kwangwon Province who visited the Health Care Center, Asan Kangnung Hospital from September 11th to August 31th. HBsAg, AntiHBc-lgG, and AntiHBs were tested by radioimmunoassay.

Results : Positive rate of HSsAg of total study subjects was 8.5%, and significantly decreased as age increased, and higher in males(10.2%) than in females (6.6%). Positive rate for one or more markers among HBsAg, AntiHBc-lgG, and AntiHBs was 84%, and was significantly increased as age increased, and higher in males(86.2%) than in females(81.2%). All negative rate for HBsAg, AntiHBc-lgG, and AntiHBs was 16.0% and all positive rate was 0.5%. Positive rate of AntiHBc-lgG without HBsAg and AntiHBs was 15.7% Positive rate of AntiHBs without HBsAg and AntiHBc-lgG was 11.7%. Positive rate of AntihHBc-lgG and AntiHBs was 72.1% and 60.2%, respectively.

Conclusion : There was no significant difference in positive rate of HBsAg between this study for residents in Yongdong area of Kwangwon Province and past many reports. 84% of the total study subjects showed serological evidence of previous exposure to hepatitis B virus (HBV) naturally exposed or by vaccine immunization. 16% of the total study subjects was a proper candidate for hepatitis B vaccination.
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The change of health-related behavior after health examination.
Kyeong Soo Cheon, Mi Kyeong Oh, Yeong Jeon Shin, Bo Youl Choi
J Korean Acad Fam Med 1999;20(8):1012-1026.   Published online August 1, 1999
Background
: In a health examination program, advice from physician for change of health-related behavior and distribution of health educational pamphlets is routine. This study was done prospectively to analyze factors such as personal general characteristics, results of health examination, health examination satisfaction that related to change of health promotion attitudes and compliance towards overweight, smoking, heavy drinking, elevated blood pressure, dyslipidemia, chronic diseases such as diabetes, hypertension.

Methods : The subject population was 689 cases from May 1997 to Jue 1997i a general hospital health examination center. After health examination, 60.2%(415 cases) showed personal satisfaction by questionnaire. Three to four months later 78.4%(540 cases) responded to eh telephone survey on change of health beliefs, health-related attitudes and compliance.

Results : In the telephone survey, 239 cases(46.0%) comprised high compliance group that had positive attitudes toward abnormal health examination results, 145 cases(27.9%) were mid compliance group. In males there was higher frequency of high compliance group than females(p<0.05). According to age, the older, the higher frequencies of high compliance group(p<0.05). In educational level group, the higher the educational level, the lower the frequencies of high compliance group(p<0.01). There was no difference in frequency of each compliance group between symptom motive and non-symptom motive group with each satisfaction group(p>0.05). In positive responders to the correspond advice of physician or health educational pamphlets, the frequencies for quit smoking, reduction of drinking amount, regular exercise, Compliance with taking antihypertensive, blood sugar control, diet control for dyslipidemia, taking antihyperlipidemics were higher(p<0.01).

Conclusion : Health examination service including advice of physician and education changed health belief and influenced positively to health promotion attitudes. Health examination is not only important for early detection of disease but also to promote positive change of health-related behavior. Further studies are needed to understand the changing process of management of health and disease.( J Korean Acad Fam Med 1999;20:1012-1026)
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The effect of smoking on eradication of helicobacter pylori.
Mi Kyeong Oh, Woo Seuk Choi, Young Bin Lee, Haingsub R Chung, Gil Hyun Kang, Jong Sung Kim
J Korean Acad Fam Med 1999;20(8):991-999.   Published online August 1, 1999
Background
: Helicobacter pylori(H. Pylori) is a major risk factor for chronic gastritis, peptic ulcer, and low grade gastric lymphoma of mucosa-associated lymphoid tissues(MALT). Eradication of H. pylori can induce prevention of peptic ulcer relapse and regression of gastric MALT lymphoma. Smoking has also been known to be a major risk factor for peptic ulcer. The purpose of this study is to evaluate the effects of smoking on eradication of H. pylori according to smoking status, amount of smoking, and smoking cessation.

Methods : We studied 132 patients with H. pylori-positive gastroduodenal diseases. Diseases com-posed of gastritis in 36.4%, peptic ulcer 62.1%, gastric MALT lymphoma 1.5%. Patients were treated with amoxicillin 1.0g, clarithromycin 500mg, omeprazole 20mg bid for a period of 7 days. Patients underwent a follow-up gastroendoscopy 6 weeks later after eradication treatment. H. Pylori status was confirmed by initial and follow up biopsies of gastric antrum and corpus using Hematoxylin0Eosin stain and Wharthin0Starry silver stain. At the beginning of treatment, 66.7% of 132 patients were smokers, 9.8% ex-smokers, 25.3% non-smokers. Smokers were advised to stop smoking through education and counseling at each office visit.

Results : H. Pylori eradication was achieved in 111 patients(84.1%). The number of smokers who had quit smoking successfully during treatment were 25(28.4%). The rate of eradication did not seem to influence by initial smoking status and total amount of smoking(pack-years). However, during treatment, success group for smoking cessation(100%) had a higher rate or eradication than non-cessation group. Daily amount of smoking had an effect o eradication with significant statistical difference; Non-smokers showed 89.9% eradication rate, mild smokers (≤20 cigarettes/day) 81.8%, and heavy smokers ( >20/day) 50%.

Conclusion : These results suggest that current smoking status and daily amount of smoking during treatment seem to influence the rate of eradication of H. Pylori rather than past smoking history alone. There was some improvement in the eradication rate by quitting or reducing smoking together with H. Pylori eradication treatment. ( J Korean Acad Fam Med 1999;20:991-999)
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Validity of the clinical recommendation of Hepatitis B virus vaccine to adults with negative HBsAg and AntiHBs.
Mi Kyeong Oh, Kyeong Soo Cheon, Jong Sung Kim, Byoung Kang Park
J Korean Acad Fam Med 1997;18(10):1027-1034.   Published online October 1, 1997
Background
: Administration of hepatitis B vaccine has played a major part in the man-agment of public health in this country. There were many researches to assess the immunogenecity, safety, long-term ffectiveness, does, and route of administration of hepa-titis B vaccine. But there was lack of validation of the recommendation that hepatitis B vaccine should be administered in adults with negative HBsAg and AntiHBs, in an endemic area with high prevalence of HBsAg. Authors tried to establish a proper candidate for hepatitis B vaccination evaluating viral markers of hepatitis B in adults vaccinated.

Methods : 172 hepatitis B vaccinated-subjects(35.0%) were drawn from 491 adults who have visited at health care center, Asan Kangnung Hospital from April 1st to May 31th, 1997. They were asked designed questions about the beginning year, frequency of vaccina-tion, and the presence of family members with HBsAg in a direct line.

Results : Of the subejcts(172), 2.3% were HBsAg(+), 63.4% AntiHBs(+), 68.6% AntiHBc(+). Among the HBsAg(-) adults(149) who had been vacinated more than three times, 70.4%(105) were AntiHBs(+), of whom 66.6%(70) were AntiHBc(+) and 29.6%(44) were AntiHBs(-), of whom 56.8%(25) were AntiHBc(+). In the subjects(20) with family history of HBsAg, 80% were AntiHBc(+), which is higher than 61.2% in the group(129) without family history. Among the HBsAg(-) and AntiHBc(-) adults(54) who had been vaccinated more than three times, AntiHBs(+) group was not significantly different from AntiHBs(-) group in comparison of age and years after initial vaccination.
Conslusions: The two thirds(68.9%) of vaccinated subjects showed AntiHBc(+), which means reflection of previous exposure to Hepatitis B virus. Accordingly, vaccination is not thought to be required for these. Consequently, all individuals are thought to have to be pretested for the presence of AntiHBc as well as HBaAg and AntiHBs in Korea.
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