Background
Prediabetes is a metabolic state between normoglycemia and diabetes and is known to carry a higher risk of developing overt diabetes and cardiovascular disease (CVD). The relative and absolute risks of all-cause mortality, CVD, coronary heart disease, and stroke in prediabetes patients, as well as in diabetic patients, is higher than that in patients with normoglycemia. Carotid intima-media thickness (cIMT) is a method used to stratify CVD risk. In this study, we aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR) correlates with cIMT in prediabetes patients.
Methods
From January 1, 2016, to February 20, 2021, 581 adults their 30s–70s who underwent carotid ultrasonography as part of a comprehensive medical examination at the Dongtan Sacred Heart Hospital were enrolled. Statistical analysis using SPSS presented t-test and chi-square test significance levels into a group with normal cIMT (nIMT; cIMT <1 mm) and a group with thick cIMT (tIMT; cIMT ≥1 mm). Binary logistic regression analysis was performed to confirm the correlation between NLR and cIMT.
Results
In prediabetic adults, age, hemoglobin A1c (HbA1c), systolic blood pressure, and NLR were significantly higher in the tIMT group than in the nIMT group. In the regression analysis, NLR, age, and HbA1c were significantly correlated with cIMT.
Conclusion
NLR was significantly higher in the tIMT group than in the nIMT group; therefore, NLR may be used to assess CVD risk in prediabetes patients.

Citations

• The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes
  Zeki Dogan, Abdulhalim Senyigit, Sinem Durmus, Canan Duvarcı, Remise Gelişgen, Hafize Uzun, Omur Tabak
  Scientific Reports.2025;[Epub]     CrossRef
• Triglyceride–glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride–glucose strata
  Xueguang Lin, Shishuai Xie, Bingbing Pu, Zheyu Wang, Hui Zhang, Yunxia Li, Jingdong Tang, Bo Yu, Shuai Jiang
  BMC Cardiovascular Disorders.2025;[Epub]     CrossRef
• Exploring the Correlation between Systemic Inflammatory Markers and Carotid Atherosclerosis Indices in Middle-Aged Adults: A Cross-Sectional Study
  Ji-Eun Song, Ji-In Hwang, Hae-Jin Ko, Ji-Yeon Park, Hee-Eun Hong, A-Sol Kim
  Journal of Cardiovascular Development and Disease.2024; 11(3): 73.     CrossRef
• Could Systemic Inflammation in Healthy Individuals With Obesity Indicate Subclinical Atherosclerosis?
  Nail B. Ozbeyaz, Gokhan Gokalp, Engin Algul, Pinar Kilic, Orkun Saricam, Faruk Aydinyilmaz, Ilkin Guliyev
  Angiology.2023; 74(1): 62.     CrossRef
• A Relação entre a Relação Ácido Úrico/Albumina e a Espessura Média-Intimal da Carótida em Pacientes com Hipertensão
  Faysal Şaylık, Tufan Çınar, Murat Selçuk, İbrahim Halil Tanboğa
  Arquivos Brasileiros de Cardiologia.2023;[Epub]     CrossRef
• A Study to Assess and Correlate Metabolic Parameters with Carotid Intima-Media Thickness after Combined Approach of Yoga Therapy Among Prediabetics
  Neha Saboo, Sudhanshu Kacker
  Advanced Biomedical Research.2023;[Epub]     CrossRef

Background
Malnutrition is a well-known risk factor of falls, although studies examining the association between nutritional status and falls are rare. We aimed to investigate the association between nutritional status and falls according to gender among Korean older adults.
Methods
The study included 10,675 participants (4,605 men and 6,070 women) aged 65 years and older and used data from the 2011 Survey of Living Conditions and Welfare Needs of Korean Older Persons. Nutritional status of the participants was assessed using the Nutritional Screening Initiative checklist, and the participants were categorized into the following groups: “good,” “moderate nutritional risk,” and “high nutritional risk.” Odds ratios (OR) of fall risk in the above groups based on gender were evaluated using multivariate logistic regression analyses.
Results
Fallers in both genders showed significant association with older age, lower household income, inadequate exercise, and poor nutritional status compared with non-fallers. Considering the good nutritional status group as the reference group, the high nutritional risk group showed a higher risk of falls in men (OR, 1.59; 95% confidence interval [CI], 1.26–1.99); both moderate and high nutritional risk groups showed a higher risk of falls after adjusting for confounding factors in women (OR, 1.39; 95% CI, 1.19–1.62 and OR, 1.90; 95% CI, 1.61–2.24, respectively).
Conclusion
The risk of falls was associated with poor nutritional status, and statistical significance of the association between nutritional status and falls was stronger in women than in men.

Citations

• Mapping sex and gender differences in falls among older adults: A scoping review
  Crista Sebastiani, Jamie Yee Xin Wong, Amandeep Litt, Julia Loewen, Karly Reece, Nicole Conlin, Tessa Dunand, Manuel Montero Odasso, Cassandra D'Amore, Stephanie Saunders, Marla Beauchamp
  Journal of the American Geriatrics Society.2024; 72(3): 903.     CrossRef
• Temporal trends and the association between self-rated oral health and falls in community-dwelling older adults in South Korea: a secondary analysis of survey data
  Hyun-Ju Seo, Soon-Ki Ahn, Min-Jung Choi
  BMJ Open.2024; 14(4): e081549.     CrossRef
• Age and Gender Differences in Fall-Related Factors Affecting Community-Dwelling Older Adults
  Minhee SUH, Da Hye KIM, Insook CHO, Ok Kyung HAM
  Journal of Nursing Research.2023; 31(2): e270.     CrossRef
• Development of a protein energy malnutrition screening tool for older Thais in public residential homes
  Thitima Phodhichai, Warapone Satheannoppakao, Mathuros Tipayamongkholgul, Carol Hutchinson, Siriphan Sasat
  Public Health Nutrition.2022; 25(3): 565.     CrossRef
• Current status of nutrient intake in Korea: focused on macronutrients
  Seung-Won Oh
  Journal of the Korean Medical Association.2022; 65(12): 801.     CrossRef