Acute pancreatitis is a sudden inflammation affecting the exocrine region of the pancreatic parenchyma. Infectious etiologies are rare. Here we report an exceptional case of a 44-year-old woman from a rural area who was referred to our hospital with fever and abdominal pain. A physical examination revealed pale skin and epigastric tenderness. Thoracoabdominal computed tomography revealed a Balthazar score of D. Serum laboratory findings revealed hemolytic anemia, hepatic cytolysis, and high C-reactive protein level. Calcium and lipase levels were normal. There was no history of recent trauma, alcohol consumption, or drug intoxication. The diagnosis of “query” pancreatitis was confirmed by serological Coxiella burnetii positivity. Oral doxycycline 200 mg daily was initiated. The clinical evolution was favorable. To our knowledge, no association between acute pancreatitis and hemolytic anemia caused by C. burnetii was reported previously. Q fever must be considered in cases of acute pancreatitis, especially when the patient is from a rural area or has a high-risk profession.

Background
Being common, mild anemia is sometimes considered a mere consequence of aging; however, aging alone is unlikely to lead to anemia. Therefore, this study aimed to investigate the association between mild anemia and total mortality and cause-specific mortality in apparently healthy elderly subjects.
Methods
A retrospective cohort study was conducted on 10,114 apparently healthy elderly individuals who underwent cancer screening and routine medical check-ups at one Health Promotion Center between May 1995 and December 2007. We defined mild anemia as a hemoglobin concentration between 10.0 g/dL and 11.9 g/dL in women and between 10.0 g/dL and 12.9 g/dL in men. We assessed the relationship between the overall, cardiovascular (CV), and cancer mortality and mild anemia using Cox proportional hazard models.
Results
Mild anemia was present in 143 men (3.1%) and 246 women (6.1%). During an average follow-up of 7.6 years, 495 deaths occurred, including 121 CV and 225 cancer deaths. After adjustments, mild anemia was associated with a 128% increase in the risk of all-cause mortality hazard ratio (HR, 2.28; 95% confidence interval [CI], 1.54– 3.37) in men and cancer-related mortality (HR, 2.25; 95% CI, 1.22–4.13), particularly lung cancer (HR, 2.70; 95% CI, 1.03–7.08) in men, but not in women. In the subgroup analyses based on smoking status, obesity, and age, the associations were more prominent in never or former smoker groups and the older group.
Conclusion
The present study shows that overall and cancer-related mortality was associated with mild anemia in elderly men. Future prospective studies are needed to consolidate our findings.

Citations

• Anemia, Iron Deficiency, and Cause-Specific Mortality: The Atherosclerosis Risk in Communities Study
  Ethan J. Cannon, Jeffrey R. Misialek, Leo F. Buckley, Iman A.F. Aboelsaad, Christie M. Ballantyne, John Leister, James S. Pankow, Pamela L. Lutsey
  Gerontology.2024; 70(10): 1023.     CrossRef
• The Effect of Anemia on Prognostic in Non-Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy
  Ulfah Kartikasari, Suryanti Dwi Pratiwi, Tri Wahju Astuti, Nanik Setijowati
  Jurnal Respirasi.2024; 10(2): 120.     CrossRef
• Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years
  Sonali R. Gnanenthiran, Austin C.C. Ng, Robert G. Cumming, David B. Brieger, David G. le Couteur, Louise M. Waite, Markus Seibel, David J. Handelsman, Vasi Naganathan, Leonard Kritharides, Fiona M. Blyth
  Canadian Journal of Cardiology.2022; 38(6): 745.     CrossRef
• Hematopoiesis, Inflammation and Aging—The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals
  Øystein Bruserud, Anh Khoi Vo, Håkon Rekvam
  Journal of Clinical Medicine.2022; 11(3): 706.     CrossRef
• Prevalence and Associated Factors of Anemia among Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study
  Fares M.S Muthanna, Mahmathi Karuppannan, Egbal Abdulrahman, Suriyon Uitrakul, Bassam Abdul Hassan Rasool, Ali Haider Mohammed, Abdelhakim Bouyahya
  Advances in Pharmacological and Pharmaceutical Sciences.2022; 2022: 1.     CrossRef
• On-Admission Anemia and Survival Rate in COVID-19 Patients
  Reza Asadzadeh, Aliashraf Mozafari, Elham Shafiei, Mohammadreza Kaffashian, Iraj Ahmadi, Mohammadzaman Darvish, Saiyad Bastaminejad
  Iranian Biomedical Journal.2022; 26(5): 389.     CrossRef
• Exploring biomarkers in routine diagnostics for the risk stratification of older patients in the Chest Pain Unit: a prospective cohort study
  Anna Lisa Kunz, Anton Schönstein, Philipp Bahrmann, Evangelos Giannitsis, Hans-Werner Wahl, Hugo A Katus, Norbert Frey, Anke Bahrmann
  BMJ Open.2022; 12(12): e056674.     CrossRef
• ASSOCIATION OF ANEMIA WITH EXTRASYSTOLIA IN PATIENTS WITH SENIOR ASTHENIA
  Aksyutina N.V., Davydov E.L., Bolshakova T.Yu., Nadezhdina D.A., Voronin I.S., Suleymanov Yu.S., Matryonina A.V., Kusaev V.V.
  "Medical & pharmaceutical journal "Pulse".2022; : 80.     CrossRef
• A patient with cardiovascular disease and anaemia: fatal combination or consistent pattern?
  N. O. Khovasova, A. V. Naumov
  Russian Journal of Geriatric Medicine.2020; (1): 81.     CrossRef
• High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES
  Hee Won Chueh, Hye Lim Jung, Ye Jee Shim, Hyoung Soo Choi, Jin Yeong Han
  BMC Geriatrics.2020;[Epub]     CrossRef

Background
Sickle cell disease is an autosomal recessive condition that results from the presence of a mutated form of hemoglobin. Some genetic variants of BCL11A are amenable to therapeutic manipulation. The present study investigated the relationship of a BCL11A variant (rs1427407) and its plasma levels with vaso-occlusive crises and stroke complications among patients in Sudan with sickle cell disease.
Methods
This cross-sectional study was performed between June 2014 and October 2016. The subjects included 166 patients who were diagnosed with sickle cell disease and 35 healthy control subjects, who were grouped according to sex and age (<15 years, 15–25 years, and >25 years). All patients and/or their guardians provided informed consent. Blood samples were collected from the patients and controls under aseptic conditions.
Results
Plasma BCL11A levels were elevated in cases with vaso-occlusive crises that lasted for >3 years. In addition, plasma BCL11A levels were high in cases with the GG genotype (vs. GT and TT) at rs1427407. Furthermore, the BCL11A rs1427407 GG/GT genotypes increased the risk of vaso-occlusive crisis and stroke in the patients with sickle cell disease.
Conclusion
The BCL11A variant (rs1427407) and its plasma levels were associated with vaso-occlusive crisis and stroke in patients with sickle cell disease.

Citations

• Genetic Variants Associated with the Risk of Stroke in Sickle Cell Anemia: Systematic Review and Meta-Analysis
  Aradhana Kumari, Ganesh Chauhan, Partha Kumar Chaudhuri, Sushma Kumari, Anupa Prasad
  Hemoglobin.2024; 48(2): 101.     CrossRef
• Genetic Modifiers of Stroke in Patients with Sickle Cell Disease—A Scoping Review
  Morohuntodun O. Oni, Miguel Brito, Chloe Rotman, Natasha M. Archer
  International Journal of Molecular Sciences.2024; 25(12): 6317.     CrossRef
• Genetic Variation and Sickle Cell Disease Severity
  Justin K. Kirkham, Jeremie H. Estepp, Mitch J. Weiss, Sara R. Rashkin
  JAMA Network Open.2023; 6(10): e2337484.     CrossRef

Background
Iron is an essential element for women of reproductive age, especially in the period before and during the pregnancy. This study investigates the consumption of iron to prevent iron deficiency anemia among pregnant women visiting Neyshabur healthcare centers based on the theory of planned behavior.
Methods
In this experimental study, data were collected through a questionnaire survey. It included 160 pregnant women who were receiving maternity services at twelve healthcare centers in the city of Neyshabur in Iran between 2015 and 2017. The participants’ demographic and anthropometric characteristics, Using the theory of planned behavior, and blood lab examination results, including ferritin levels were measured and the data were analyzed using IBM SPSS ver. 22.0 (IBM Corp., Armonk, NY, USA).
Results
The average scores of knowledge, attitude, perceived behavioral control, subjective norms, and intention categories for the intervention group were meaningfully increased after the participants received education on iron supplementation (P<0.05). However, these changes were not found to be significant in the control group (P>0.05). No statistically significant difference was obtained in the subjective norms category between the two groups after the education intervention (P=0.92).
Conclusion
Based on the experimental effects of education encouraging iron supplementation in pregnant women, it is suggested that workshops promoting iron supplementation should be conducted in health centers with the aim of preventing widespread iron deficiency anemia.

Citations

• Effectiveness of a Web-Based Medication Education Course on Pregnant Women’s Medication Information Literacy and Decision Self-Efficacy: Randomized Controlled Trial
  Suya Li, Hui-Jun Chen, Jie Zhou, Yi-Bei Zhouchen, Rong Wang, Jinyi Guo, Sharon R Redding, Yan-Qiong Ouyang
  Journal of Medical Internet Research.2025; 27: e54148.     CrossRef
• Nursing Intervention "EducaTHE" to Improve Knowledge and Self-care Behaviors for Hypertensive Disorders in Pregnant Women: a Randomized Controlled Pilot Study
  Iliana Milena Ulloa Sabogal, Mauricio Arias Rojas
  Investigación y Educación en Enfermería.2025;[Epub]     CrossRef
• Factors affecting parental awareness of the nutritional intake to their children’s growth
  T H S T Abu Bakar, S Z Ibrahim, S Zakaria, M M Nor, N M Zain, S N H Mohammad Azmin, J Y Liew, F A Abdullah, F Rosli
  IOP Conference Series: Earth and Environmental Science.2024; 1397(1): 012024.     CrossRef
• Effectiveness of Health Education Interventions in Enhancing Iron-Folic Acid Supplement Utilization Among Pregnant Women: Systematic Review and Meta-analysis
  Jira Wakoya Feyisa, Judy Yuen-Man Siu, Xue Bai
  Nutrition Reviews.2024;[Epub]     CrossRef
• Reproductive health of women with endometriosis: an improving educational intervention based on the planned behavior theory
  Niusha Zandi, Zahra Behboodi Moghadam, Batool Hossein Rashidi, Masoumeh Namazi, Shima Haghani
  Middle East Fertility Society Journal.2023;[Epub]     CrossRef
• Salient Beliefs in the Intention for Self-Care Behaviors when Facing Hypertensive Disorders in Pregnant Women
  Iliana Milena Ulloa Sabogal, Edier Mauricio Arias Rojas
  Aquichan.2023; 23(2): 1.     CrossRef
• Telephonic intervention to combat non-adherence to oral iron-folic acid supplementation in pregnancy: A randomized controlled trial
  Sakshi Sharma, M.V. Smitha, Deepthy Balakrishnan
  European Journal of Obstetrics & Gynecology and Reproductive Biology: X.2023; 20: 100235.     CrossRef
• Instrumento “Determinantes del comportamiento de autocuidado ante hipertensión en el embarazo”
  Iliana Milena Ulloa Sabogal, Mauricio Arias-Rojas , Diego Alejandro Salazar Blandón
  Avances en Enfermería.2023;[Epub]     CrossRef
• The effect of educational intervention based on the theory of planned behavior aimed at mothers on osteoporosis prevention behaviors in lower secondary school female students
  Fatemeh Shahmohamadi, Meimanat Hoseini, Mahsa Matbouei, Malihe Nasiri
  Journal of Education and Health Promotion.2022; 11(1): 15.     CrossRef
• Interventions to increase adherence to micronutrient supplementation during pregnancy: a systematic review
  Filomena Gomes, Shannon E. King, Diana Dallmann, Jenna Golan, Ana Carolina Feldenheimer da Silva, Kristen M. Hurley, Gilles Bergeron, Megan W. Bourassa, Saurabh Mehta
  Annals of the New York Academy of Sciences.2021; 1493(1): 41.     CrossRef
• Effectiveness of Theory of Planned Behavior-Based Educational Intervention on Newborn Care in Pregnant Mothers: A Quasi-experimental Study
  Azamalsadat Navabi, Mohsen Shamsi, Mahboobeh Khorsandi, Maryam Zamanian
  Jundishapur Journal of Health Sciences.2021;[Epub]     CrossRef
• Determining Prevalence of Anemia and Its Associated Factors in Cameroon: A Multilevel Analysis
  Betregiorgis Zegeye, Bight Opoku Ahinkorah, Edward Kwabena Ameyaw, Abdul-Aziz Seidu, Mpho Keetile, Sanni Yaya, Han T.N. Nguyen
  BioMed Research International.2021;[Epub]     CrossRef
• Effect of educational program based on theory of planned behavior on promoting nutritional behaviors preventing Anemia in a sample of Iranian pregnant women
  Ali Khani Jeihooni, Tayebeh Rakhshani, Pooyan Afzali Harsini, Mehdi Layeghiasl
  BMC Public Health.2021;[Epub]     CrossRef
• Folic acid consumption based on the theory of planned behaviour in pregnant women
  Zeinab Jalambadani, Maryam Delavari Heravi, Malihe Noori Sistani
  Journal of Obstetrics and Gynaecology.2020; 40(1): 37.     CrossRef
• The Effect Of Fe Tablet Consumption On Hemoglobin (Hb) Increase In Pregnant Women: A Systematic Literature Review
  Pratiwi Cahya Skania, Djaswadi Dasuki, Fitriana Siswi Utami
  Jurnal Kebidanan Midwiferia.2020; 6(2): 8.     CrossRef
• The effect of educational intervention on iron and vitamin D consumption based on the theory of planned behaviour in Iranian adolescent girls: a quasi-experimental study
  Ali Alami, Seyedeh Belin Tavakoly Sany, Hadi Tehrani, Elaheh Lael- Monfared, Zahra Hosseini, Alireza Jafari
  International Journal of Health Promotion and Education.2019; 57(6): 316.     CrossRef

Citations

• The interrelation between spirometric and erythrocyte indices in chronic obstructive pulmonary disease and its combination with hypothyroidism
  S. V. Kashul, O. S. Khukhlina
  Reports of Vinnytsia National Medical University.2025; 29(1): 64.     CrossRef
• Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review
  Yurong Xiang, Xiaobin Luo
  International Journal of Chronic Obstructive Pulmonary Disease.2024; Volume 19: 567.     CrossRef
• Anemia in chronic obstructive pulmonary disease: A systematic review
  Mohsen Alisamir, Mina Ebrahimi, Fakher Rahim
  Respiratory Investigation.2022; 60(4): 510.     CrossRef
• Study of lung function test in association with laboratory findings of serum iron in patients with chronic obstructive pulmonary disease
  Sunil Kumar Gothwal, Vikram Palsaniya, Harish Chandra Barjatiya, Ruchita Banseria, Piush Sharma, Pramod Kumar Goyal, Vasudeva Murthy Challakere Ramaswamy, Yogendra Singh, Gaurav Gupta
  Clinical Epidemiology and Global Health.2022; 16: 101091.     CrossRef

We report three cases of iron defi ciency anemia due to long-time bloodletting using cupping. Case 1 was a 52-year-old man who sought evaluation at the Health Promotion Center in our hospital due to fatigue and dyspnea on exertion (DOE). There were no abnormal fi ndings on his general health examination, except anemia. He has performed self-bloodletting for a long time with cupping on his back and extremities for fatigue, myalgias, or polyarthralgias. Case 2 was a 52-year-old woman with fatigue and DOE. The physical examination revealed a systolic murmur at her left lower anterior chest and pale conjunctiva. The initial hematocrit was 22.4% and the hemoglobin was 6.4 g/dL. She has self-bloodletted using cupping 2 to 3 times a week when she felt tired or had myalgias. Case 3 was a 35-year-old man with sudden onset fatigue and DOE. He had severe DOE during a challenging physical test. He frequently received bloodletting using cuppings on his back and extremities by a doctor of Oriental medicine. There were no abnormal findings on the general health examination, except anemia. All three patients were diagnosed with iron defi ciency anemia due to chronic blood loss. We recommended stopping bloodletting using cupping and prescribed oral iron supplements.

Citations

• Bloodletting for Acute Stroke Recovery: A Systematic Review and Meta-Analysis
  Mikyung Kim, Changho Han
  Healthcare.2024; 12(20): 2060.     CrossRef
• Adverse events related to cupping therapy in studies conducted in Korea: A systematic review
  Tae-Hun Kim, Kun Hyung Kim, Jun-Yong Choi, Myeong Soo Lee
  European Journal of Integrative Medicine.2014; 6(4): 434.     CrossRef

Background
: Helicobacter pylori has been known to be not only associated with gastrointestinal diseases but also to be reported in several cases of increased incidence of anemia. The anemia associated with H. pylori infection was reported though the population studies and case reports. But in Korea, there have been not enough studies especially in adults group, so we investigated to find out if H. pylori infection is associated with anemia in adults with gastritis.

Methods : Subjects were 382 men older than 40 years and 158 postmenopausal women, who had visited a general hospital for physical examination from May 2001 to October 2001 and diagnosed as only gastritis. Data were analysed for the effects of H. pylori infection on anemia using logistic regression test.

Results : In men, Pearson correlation coefficients between age and hemoglobin, and hematocrit were -0.163, -0.136, respectively (P＜0.01). In women, Pearson correlation coefficients between age and hemoglobin, and hematocrit were 0.180 (P＜0.05), 0.031 (P＞0.05) respectively. Logistic regression analysis adjusted for age showed the lower odds ratio for anemia in both men and women without H. pylori than in those with H. pylori, but it was not significant.

Conclusion : H. pylori infection seems not to affect hemaglobin and hematocrit in the middled-aged men and the postmenopausal women with gastritis. Further investigations will be necessary for various individuals including infants and premenopausal women who may have high incidence for anemia.

Background
: The hemoglobin is a basic tool in diagnosing anemia. Not many studies compared hemoglobin between non-smokers and smokers in Korea and they did not differentiate hemoglobin between males and females. This study was conducted to show the difference of hemoglobin between non-smokers and smokers in male population and factors affecting hemoglobin.

Methods : We gathered 313 men who underwent periodic health examination from May to July 2001 in a general hospital. The relationship between cigarette smoking and hemoglobin concentration was examined by comparing the means of hemoglobin between two groups and through multiple regression analysis.

Results : The mean of hemoglobin was significantly higher in smokers than in non-smokers, especially in smokers with more than 1 pack per day. The factors that influence the hemoglobin level were age, the amount per day, and the total amount they smoked in the past(pack-year). Daily cigarette smoking seemed to cause a general upward shift of hemoglobin distribution curve, while age and pack-year on the opposite.

Conclusion : The study suggests that hemoglobin cutoff values should be adjusted for smokers and one must consider the patient's age to compensate for masking effect of smoking and aging on detection of anemia.