Background Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults.
Methods The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined.
Results Higher serum UA levels were associated with decreased levels of d-ROMs (P<0.05). The UA levels were positively associated with BAP levels (P<0.001).
Conclusion Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans.
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Background : There are several reports that vitamin C is one of antioxidants and can be used to protect cardiovascular diseases. Inflammation plays a major role in atherosclerosis, and the measurement of inflammatory markers such as high-sensitivity C-reactive protein (hs- CRP) may provide methods for risk prediction and reveal independent risk factors of cardiovascular diseases. The purpose of our study was to assess the correlation between vitamin C intake and plasma hs-CRP concentration.
Methods : The study subjects consisted of 2,012 individuals who underwent periodic health examination in a university hospital in Busan from June 2002 to January 2003. The subjects were questioned concerning their past medical history, alcohol intake, smoking status, physical activity. Body mass index, abdominal circumference, blood pressure, fasting glucose, lipid profile, general blood test, and hs-CRP were measured. The exclusive responsible dietitian evaluated the average calorie intake and vitamin C intake by food frequency questionnaire. To quantify the correlation between vitamin C intake and plasma hs-CRP concentration, Pearson correlation coefficient and Spearman correlation coefficient were presented.
Results : The vitamin C index (r=-0.051, P＜0.05) and the vitamin C intake per calorie intake (r=-0.075, P＜0.01) showed a significant correlation with the plasma hs-CRP level. The vitamin C intake and the vitamin C intake per calorie intake were significantly correlated with the plasma hs-CRP level after adjusting for sex, age, body mass index and smoking status.
Conclusion : These findings suggest that there was a significant correlation between the vitamin C intake and the hs-CRP concentration. Therefore, inflammatory status is higher in a person who takes small amount of vitamin C than a person who takes it plentifully. The former is presumed to have a higher risk of cardiovascular diseases thereafter.
Background : The modern people ilive in excessive stress. This stress seems to be related to various diseases. The increase of daily stressful life also seems to relate closely to serum lipids and antioxidants. This study attempted to show how much daily life stress affects serum lipids and antioxidants.
Methods : sixty one healthy people who visited health screening center of a university hospital were enrolled for this study from October to November, 1998. In the survey of daily life stress, the Holmes and Rahe’s Readjustment Rating Scale, which was modified by Hong and Jung were used. The subjects were interviewed about the life stress during the past one year. The levels of retinol, B-carotene, vitamin C, tocopherol, HDL-cholesterelol, LDL-cholesterol, total cholesterol, triglyceride were measured. The subjects were divided into three groups by the stress scores. Kruaskal-Wallis test was used for analysis. Dependent variables were antioxidants in each group.
Results : There was no significant meaning in the comparison between each stress groups and the level of serum lipids, and between each stress group and the level of antioxidants.
Conclusion : The level of antioxidants was not related to stress. More studies are needed for further evaluation of the results.
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