Korean Journal of Family Medicine

"Copper"

Original Article

Association between Copper–Zinc Ratio in Hair and Neutrophil–Lymphocyte Ratio within the Context of a Normal White Blood Cell Count among Overweight or Obese Korean Individuals: A Pilot Study: Sun Young Jeong, Hyo Young Shim, Yong Jae Lee, Byoungjin Park; Korean J Fam Med 2021;42(3):240-244. Published online June 17, 2020; DOI: https://doi.org/10.4082/kjfm.20.0018

Abstract
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Background
Obesity is considered a state of enhanced oxidative stress as well as chronic and low-grade inflammation. The copper–zinc ratio in obese individuals has been reported to reflect systemic oxidative stress and inflammatory status. We investigated whether the neutrophil–lymphocyte ratio is related to the copper–zinc ratio in hair, within the context of a normal white blood cell count among overweight or obese Korean individuals.
Methods
We included 56 participants aged older than 20 years who voluntarily sought weight reduction treatment and met the inclusion criterion of body mass index of 23 kg/m² or greater. Intra-abdominal visceral adipose tissue was measured by computed tomography imaging, while the copper and zinc levels were measured by hair mineral analysis. Using multiple linear regression analysis, we examined the associations between the neutrophil–lymphocyte ratio and the copper–zinc ratio.
Results
The mean age, body mass index, and visceral adipose tissue were 46.0±10.5 years, 29.0±4.1 kg/cm² , and 142.9±68.8 cm² , respectively. Pearson’s correlation analysis revealed the association of the neutrophil–lymphocyte ratio with copper level (r=0.475, P<0.001) and copper–zinc ratio (r=0.494, P<0.001). After adjusting for confounding variables, we found the neutrophil–lymphocyte ratio was significantly associated with the level of copper and the copper–zinc ratio in hair (regression coefficient: 0.055±0.015; P<0.001 and regression coefficient: 0.761±0.185; P<0.001, respectively).
Conclusion
A higher copper–zinc ratio in hair is positively and independently associated with the neutrophil–lymphocyte ratio. Thus, a high hair copper–zinc ratio could be a useful parameter for oxidative burden of individuals predisposed to obesity-related comorbidity.

Citations

Citations to this article as recorded by

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The Protective Effect of the Crosstalk between Zinc Hair Concentration and Lymphocyte Count—Preliminary Report
Tomasz Urbanowicz, Anetta Hanć, Jolanta Tomczak, Michał Michalak, Anna Olasińska-Wiśniewska, Patrycja Rzesoś, Mateusz Szot, Krzysztof J. Filipiak, Beata Krasińska, Zbigniew Krasiński, Andrzej Tykarski, Marek Jemielity
Life.2024; 14(5): 571. CrossRef
Whole blood trace element and toxic metal concentration in dogs with idiopathic epilepsy and healthy dogs: A case-control study
Sarah Rosendahl, Johanna Anturaniemi, Tiina-Kaisa Kukko-Lukjanov, Kristiina A. Vuori, Robin Moore, Manal Hemida, Anne Muhle, Anna Hielm-Björkman
Frontiers in Veterinary Science.2023;[Epub] CrossRef
Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls
Sarah Rosendahl, Johanna Anturaniemi, Tiina‐Kaisa Kukko‐Lukjanov, Kristiina A. Vuori, Robin Moore, Manal Hemida, Anne Muhle, Anna Hielm‐Björkman
Journal of Veterinary Internal Medicine.2023; 37(3): 1100. CrossRef
Associations between Hair Mineral Concentrations and Skeletal Muscle Mass in Korean Adults
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Case Report

A Case of Wilson's Disease in Patient with Mildly Elevated Liver Enzymes: Young-Hye Cho, Dong-Wook Jeong, Sang-Yeoup Lee, Son-Ki Park, Ki-Tae Yoon, Yun-Jin Kim, Jeong-Ku Lee, Yu-Hyun Lee; Korean J Fam Med 2011;32(3):205-208. Published online March 31, 2011; DOI: https://doi.org/10.4082/kjfm.2011.32.3.205

Abstract
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Wilson's disease is an autosomal recessive disorder affecting copper transport; it results in the accumulation of copper in the liver, brain, and other organs. Wilson's disease is the most common inherited liver disease with more than 500 cases reported in Korea. An impairment in biliary excretion process leads to copper accumulation in the liver, which progressively damages the liver, leading to cirrhosis. Since effective treatment is available for this disease, early and correct diagnosis is very important. Here, we report a case of Wilson's disease with mildly elevated liver enzyme levels in a 29-year-old breast-feeding woman with weight loss.

Citations

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Hyun Joo Lee, Won Joon Seong, Seong Yeon Hong, Jin Young Bae
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Aliasghar Halimiasl, Parviz Ghadamli, Solmaz Ehteshami Afshar, Farideh Moussavi, Amir Hossein Hosseini
Journal of Comprehensive Pediatrics.2013;[Epub] CrossRef