Korean Journal of Family Medicine

"Ferritins"

Original Articles

Association of Coffee or Green Tea with Ferritin or Hemoglobin in Premenopausal Women: Dagyeong Lee, Wonyoung Jung, Dong Wook Shin; Korean J Fam Med 2023;44(2):87-94. Published online March 20, 2023; DOI: https://doi.org/10.4082/kjfm.22.0133

Abstract
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Background
This study aimed to examine the association between coffee or green tea consumption and ferritin or hemoglobin levels in premenopausal women.
Methods
We used the fifth Korea National Health and Nutrition Examination Survey (2010–2012), and a total of 4,322 individuals were surveyed. In women of reproductive age, average ferritin and hemoglobin levels were calculated according to coffee or green tea consumption. Covariates included in the analysis were demographic variables, such as age, body mass index, education, drinking, smoking, history of hypertension, history of diabetes diagnosis, physical activity, total energy intake, and daily iron intake.
Results
In 4,322 participants, the average hemoglobin level was 12.90±0.02 g/dL, and the average level of ferritin was 31.95±0.67 ng/mL. As a result of testing, correlation between ferritin and coffee intake and difference in ferritin levels according to coffee consumption was significant (P<0.05). In this study, a post hoc test indicated that ferritin level significantly differed between one and two cups, two and three cups, and three and one cup groups (overall P<0.001). Additionally, there was a negative correlation between ferritin level and coffee intake; ferritin level decreased by 2.09 ng/mL with a one-cup increase in daily coffee consumption.
Conclusion
In premenopausal women, coffee intake is associated with low serum ferritin levels. Our results indicate that drinking >2 cups of coffee significantly affect ferritin levels in Korean premenopausal women.

Citations

Citations to this article as recorded by

Accurate determination of aflatoxins in coffee by isotope dilution–ultrahigh-performance liquid chromatography–tandem mass spectrometry
Yared Getachew Lijalem, Hyeonwoo Yu, So Young Woo, Hyang Sook Chun, Kihwan Choi, Byungjoo Kim
Journal of Food Composition and Analysis.2025; 145: 107836. CrossRef
Women’s Health and Primary Care
Seung-Won Oh
Korean Journal of Family Medicine.2024; 45(1): 1. CrossRef
Guidelines for nutrition counseling in primary healthcare clinics
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Journal of the Korean Medical Association.2024; 67(4): 278. CrossRef
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Noman Sadiq, Yasmeen Gul, Muhammad M Bilal, Muhammad Afzal, Nasrin Mumtaz, Abdul Wahid
Cureus.2024;[Epub] CrossRef
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Sadiq Al-Mansury, Suhad J. Hadi, Hawraa H. Naji, Adnan M. Jassim, Shatha M. Abbas, Nada Khazal K. Hindi
Medical Journal of Babylon.2024; 21(3): 627. CrossRef
Association between Coffee and Green Tea Consumption and Iron Deficiency Anemia in Korea
Jungun Lee
Korean Journal of Family Medicine.2023; 44(2): 69. CrossRef

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8 Crossref

Association between Serum-Ferritin Levels and Sleep Duration, Stress, Depression, and Suicidal Ideation in Older Koreans: Fifth Korea National Health and Nutrition Examination Survey 2010–2012: Kyung Mi Kim, Hye Rim Hwang, Yun Jin Kim, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Sung In Chung; Korean J Fam Med 2019;40(6):380-387. Published online November 20, 2019; DOI: https://doi.org/10.4082/kjfm.18.0097

Abstract
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Background
Serum-ferritin levels may be associated with psychiatric symptoms among the elderly; however, this association has not been extensively studied. The aim of this study was to evaluate the association between serumferritin levels and mental health issues in older Koreans.
Methods
This cross-sectional study included large-scale national data from the Korea National Health and Nutrition Examination Survey 2010–2012. In total, 1,802 older Koreans (≥65 years old) were included. The assessed psychiatric symptoms included short sleep duration, stress, depressed mood, and suicidal ideation. Any association between serum-ferritin levels and mental health issues according to sex was examined using logistic regression analysis.
Results
The prevalence of short sleep duration, stress, depressed mood, and suicidal ideation was 50.9%, 21.7%, 18.2%, and 22.5%, respectively. In men, suicidal ideation decreased with increased serum-ferritin levels after multivariate adjustment for sociodemographic and lifestyle factors and comorbidities. The odds ratios (OR) and 95% confidence interval (CI) of suicidal ideation by quartiles of serum-ferritin level were 1 (reference), 1.132 (95% CI, 0.569–2.252), 0.453 (95% CI, 0.217–0.945), and 0.608 (95% CI, 0.295–1.253), respectively, (P for trend=0.039). In women, no trend was observed. However, compared to the lowest quartile, short sleep duration (<7 h) and stress perception were significantly decreased in the third quartile, with odds ratios of 0.601 (95% CI, 0.461–0.888), and 0.606 (95% CI, 0.386–0.952), respectively.
Conclusion
Moderate serum-ferritin levels were associated with decreased risk for suicide ideation in men, and were associated with decreased short sleep duration and stress perception in women.

Citations

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Irma Clemente, Gaia Sinatti, Antonio Cirella, Silvano Junior Santini, Clara Balsano
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Journal of Clinical Medicine.2022; 11(22): 6611. CrossRef

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Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women: Jee-Yon Lee, Jae-Min Park, Jung-Ah Hong, Duk-Chul Lee, Jee-Aee Im, Ji-Won Lee; Korean J Fam Med 2012;33(4):205-210. Published online July 25, 2012; DOI: https://doi.org/10.4082/kjfm.2012.33.4.205

Abstract
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Background

Ferritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women.

Methods

We evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years.

Results

In all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group.

Conclusion

Our findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity.

Citations

Citations to this article as recorded by

Gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults
Hyun Yoon, Yoon Sik Kim, Jun Ho Lee, Mi Young Gi, Ju Ae Cha, Jeong Min Seong, James Fielding Hejtmancik
PLOS ONE.2018; 13(6): e0199465. CrossRef
Serum ferritin level as an early indicator of metabolic dysregulation in young obese adults — a cross-sectional study
Harshitha Hitha, Damodara Gowda, Amrit Mirajkar
Canadian Journal of Physiology and Pharmacology.2018; 96(12): 1255. CrossRef