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"Reactive Oxygen Species"

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"Reactive Oxygen Species"

Original Articles
Association between Serum Uric Acid and Oxidative Stress in Korean Adults
Eun Jeong Ok, Kiyoung Kim, Sat Byul Park
Korean J Fam Med 2018;39(5):295-299.   Published online September 10, 2018
DOI: https://doi.org/10.4082/kjfm.17.0034
Background
Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults.
Methods
The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined.
Results
Higher serum UA levels were associated with decreased levels of d-ROMs (P<0.05). The UA levels were positively associated with BAP levels (P<0.001).
Conclusion
Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans.

Citations

Citations to this article as recorded by  
  • Oxidative stress and type 2 diabetes: the development and the pathogenesis, Jordanian cross-sectional study
    Khalid M Abu Khadra, Mohammad Izzat. Bataineh, Ahmad Khalil, Jumana Saleh
    European Journal of Medical Research.2024;[Epub]     CrossRef
  • The relationship between anemia and hyperuricemia and hypertension in Korean adults: the Korea National Health and Nutrition Examination Survey 2016–2018
    Sang Muk Park, Mi Young Gi, Ju Ae Cha, Hyun Ho Sung, So Young Park, Cho Hee Park, Hyun Yoon
    Current Medical Research and Opinion.2023; 39(6): 819.     CrossRef
  • Evidence for the effect of soluble uric acid in augmenting endoplasmic reticulum stress markers in human peripheral blood mononuclear cells
    Reyhane Ebrahimi, Parvin Pasalar, Hajar Shokri, Maryam Shabani, Solaleh Emamgholipour
    Journal of Physiology and Biochemistry.2022; 78(2): 343.     CrossRef
  • Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS
    Ángela Hernández-Ruiz, Belén García-Villanova, Eduardo J. Guerra-Hernández, Cayetano Javier Carrión-García, Pilar Amiano, María-José Sánchez, Esther Molina-Montes
    Antioxidants.2022; 11(2): 300.     CrossRef
  • Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus
    Iuliia Azarova, Elena Klyosova, Alexey Polonikov
    European Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry
    Masafumi Kurajoh, Shinya Fukumoto, Shio Yoshida, Seigo Akari, Takayo Murase, Takashi Nakamura, Haruka Ishii, Hisako Yoshida, Yuki Nagata, Tomoaki Morioka, Katsuhito Mori, Yasuo Imanishi, Kazuto Hirata, Masanori Emoto
    Scientific Reports.2021;[Epub]     CrossRef
  • Usefulness of routine blood test-driven clusters for predicting acute exacerbation in patients with asthma
    Ji Hyun Oh, Kyung-Min Ahn, Soo Jie Chung, Ji-Su Shim, Heung-Woo Park
    Respiratory Medicine.2020; 170: 106042.     CrossRef
  • The Postprandial Effect of Anthocyanins on Cardiovascular Disease Risk Factors: a Systematic Literature Review of High-Fat Meal Challenge Studies
    Vinicius Andre do Rosario, Jaclyn Spencer, Katrina Weston-Green, Karen Charlton
    Current Nutrition Reports.2020; 9(4): 381.     CrossRef
  • Nephrotoxic effects caused by co-exposure to noise and toluene in New Zealand white rabbits: A biochemical and histopathological study
    Amirreza Abouee-Mehrizi, Yahya Rasoulzadeh, Mehran Mesgari-Abbasi, Ahmad Mehdipour, Abbas Ebrahimi-Kalan
    Life Sciences.2020; 259: 118254.     CrossRef
  • Association of sleep quality and sleep duration with serum uric acid levels in adults
    Yu-Tsung Chou, Chung-Hao Li, Wei-Chen Shen, Yi-Ching Yang, Feng-Hwa Lu, Jin-Shang Wu, Chih-Jen Chang, Xianwu Cheng
    PLOS ONE.2020; 15(9): e0239185.     CrossRef
  • 8,246 View
  • 96 Download
  • 13 Web of Science
  • 10 Crossref
The Association between Oxidative Stress and Metabolic Syndrome in Adults
So-Won Chung, Sung-Goo Kang, Jun-Seung Rho, Ha-Na Kim, In-Sun Song, Yun-Ah Lee, Soo-Jeong Heo, Sang-Wook Song
Korean J Fam Med 2013;34(6):420-428.   Published online November 25, 2013
DOI: https://doi.org/10.4082/kjfm.2013.34.6.420
Background

In this Study, we investigated the effects of lifestyle and metabolic syndrome on free oxygen radical levels in men and women in Korea.

Methods

A total of 254 adults were included in this study from February 2011 to June 2012 at a health promotion center. Information of the lifestyles and presence of metabolic syndrome factors was obtained. Biochemical markers were measured and free oxygen radicals test (FORT) was performed on the blood.

Results

Of the 254 subjects, 86 (33.9%) had metabolic syndrome, and 187 (73.6%) were men. Between the subjects with and without metabolic syndrome, there was a significant increase in alanine aminotransferase and serum FORT values in the subjects with metabolic syndrome. Multiple linear regression analysis showed that high-sensitivity C-reactive protein (hs-CRP) (P = 0.004), metabolic syndrome (P = 0.037), and female gender (P = 0.030) were independent predictors of serum FORT values. The subjects with high fasting blood sugar level or low high density lipoprotein cholesterol levels showed high serum FORT values.

Conclusion

High hs-CRP, the presence of metabolic syndrome, and female gender were associated with the high oxidative stress. High oxidative stress was associated with the presence of metabolic syndrome.

Citations

Citations to this article as recorded by  
  • The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model
    Heba Fikry, Lobna A. Saleh, Doaa Ramadan Sadek, Hadwa Ali Abd Alkhalek
    Cell and Tissue Research.2025; 399(1): 27.     CrossRef
  • Evaluation of thiol/disulfide homeostasis and ischemia-modified albumin in metabolic syndrome patients
    Raju Rana, Shobha U Kamath, B Ananthakrishna Shastri, Shashikiran U, G Arun Maiya, Ullas Kamath, Raghavendra Rao S, Vani Lakshmi R
    Advances in Redox Research.2025; 14: 100116.     CrossRef
  • Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications
    Aditya Sri Listyoko, Ryota Okazaki, Tomoya Harada, Genki Inui, Akira Yamasaki
    Frontiers in Allergy.2024;[Epub]     CrossRef
  • An increased disulfide/native thiol ratio and oxidative stress index in metabolic syndrome patients with postprandial lipemia
    Serap Ozer Yaman, Fulya Balaban Yucesan, Asım Orem, Cihan Orem, Birgul Vanizor Kural, Huseyin Yaman
    International Journal of Diabetes in Developing Countries.2023; 43(1): 125.     CrossRef
  • The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid Profile and Oxidative Stress in Fructose-Fed Rats
    Maryam Mohammad-Sadeghipour, Mehdi Afsharinasab, Maryam Mohamadi, Mehdi Mahmoodi, Soudeh Khanamani Falahati-pour, Mohammad Reza Hajizadeh
    Journal of Obesity & Metabolic Syndrome.2020; 29(3): 198.     CrossRef
  • Diet dan Sindrom Metabolik pada Remaja Obesitas
    Rendi Aji Prihaningtyas, Nur Aisiyah Widjaja, Meta Herdiana Hanindita, Roedi Irawan
    Amerta Nutrition.2020; 4(3): 191.     CrossRef
  • Relationship between serum levels of oxidative stress and metabolic syndrome components
    Maryam Abbasian, Mehri Delvarianzadeh, Hossein Ebrahimi, Farideh Khosravi, Pirasteh Nourozi
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2018; 12(4): 497.     CrossRef
  • Effects of low‐fat milk consumption on metabolic and atherogenic biomarkers in Korean adults with the metabolic syndrome: a randomised controlled trial
    Y. J. Lee, J. A. Seo, T. Yoon, I. Seo, J. H. Lee, D. Im, J. H. Lee, K.‐N. Bahn, H. S. Ham, S. A. Jeong, T. S. Kang, J. H. Ahn, D. H. Kim, G. E. Nam, N. H. Kim
    Journal of Human Nutrition and Dietetics.2016; 29(4): 477.     CrossRef
  • The influence of BMI on the association between serum lycopene and the metabolic syndrome
    Guang-Ming Han, Ghada A. Soliman, Jane L. Meza, K. M. Monirul Islam, Shinobu Watanabe-Galloway
    British Journal of Nutrition.2016; 115(7): 1292.     CrossRef
  • Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
    Romina Hernández-Salinas, Valerie Decap, Alberto Leguina, Patricio Cáceres, Druso Perez, Ines Urquiaga, Rodrigo Iturriaga, Victoria Velarde
    Biological Research.2015;[Epub]     CrossRef
  • Oxidative Stress and Metabolic Syndrome
    Viroj Wiwanitkit
    Korean Journal of Family Medicine.2014; 35(1): 44.     CrossRef
  • 7,037 View
  • 38 Download
  • 11 Crossref
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