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"Triglycerides"

Original Articles
A Positive Association between the Atherogenic Index of Plasma and White Matter Hyperintensity
Hyun-Suk Kwon, Jun-Seong Ko, Jun-Hyuk Lee, Kil-Young Kwon, Jee-Hye Han
Korean J Fam Med 2022;43(3):193-198.   Published online May 20, 2022
DOI: https://doi.org/10.4082/kjfm.21.0129
Background
White matter hyperintensity (WMH) is a risk factor for dementia and ischemic stroke. The atherogenic index of plasma (AIP) is a simple and cost-effective marker for the prediction of various vascular diseases. In this study, we evaluated the relationship between AIP and WMH in adults without cerebrovascular accidents.
Methods
We analyzed the data of 281 adults, aged ≥26 years, who underwent brain magnetic resonance imaging (MRI) at the health promotion center of an education hospital between January 2014 and December 2018. Participants were divided into three categories according to tertiles of the AIP scores (T1: <0.20; T2: 0.20–0.48; and T3: >0.48). WMH was defined as a modified Fazekas scale score of 1–3 on brain MRI. A cubic spline curve was used to determine the linearity of the relationship between AIP and WMH. Multiple logistic regression analysis was used to evaluate the relationship between the AIP and WMH.
Results
The prevalence of WMH was 45.7% in T1, 57.0% in T2, and 66.0% in T3 (T3 vs. T1, P for post-hoc analysis=0.005). The increased odds of WMH were associated with increased AIP. The odds ratio (OR) with a 95% confidence interval (CI) for WMH of T2 and T3 compared with T1 were 1.57 (0.88–2.80) and 2.30 (1.28–4.14), respectively. After adjusting for confounding variables, the OR with a 95% CI for WMH in the T2 and T3 groups vs. the referent T1 were 1.55 (0.76–3.13) and 2.27 (1.06–4.84), respectively.
Conclusion
AIP is independently and positively associated with WMH in a healthy population.

Citations

Citations to this article as recorded by  
  • Triglyceride glucose index and Atherogenic index of plasma for predicting colorectal neoplasms in patients without cardiovascular diseases
    Muzhou Han, Hao Wang, Shuyue Yang, Siying Zhu, Guiping Zhao, Haiyun Shi, Peng Li
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • 4,018 View
  • 91 Download
  • 1 Web of Science
  • 1 Crossref
The Relationship between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome
Hyun-Gyu Shin, Young-Kwang Kim, Yong-Hwan Kim, Yo-Han Jung, Hee-Cheol Kang
Korean J Fam Med 2017;38(6):352-357.   Published online November 14, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.6.352
Background

Metabolic syndrome is associated with cardiovascular diseases and is characterized by insulin resistance. Recent studies suggest that the triglyceride/high-density lipoprotein cholesterol (TG/HDLC) ratio predicts insulin resistance better than individual lipid levels, including TG, total cholesterol, low-density lipoprotein cholesterol (LDLC), or HDLC. We aimed to elucidate the relationship between the TG/HDLC ratio and metabolic syndrome in the general Korean population.

Methods

We evaluated the data of adults ≥20 years old who were enrolled in the Korean National Health and Nutrition Examination Survey in 2013 and 2014. Subjects with angina pectoris, myocardial infarction, stroke, or cancer were excluded. Metabolic syndrome was defined by the harmonized definition. We examined the odds ratios (ORs) of metabolic syndrome according to TG/HDLC ratio quartiles using logistic regression analysis (SAS ver. 9.4; SAS Institute Inc., Cary, NC, USA). Weighted complex sample analysis was also conducted.

Results

We found a significant association between the TG/HDLC ratio and metabolic syndrome. The cutoff value of the TG/HDLC ratio for the fourth quartile was ≥3.52. After adjustment, the OR for metabolic syndrome in the fourth quartile compared with that of the first quartile was 29.65 in men and 20.60 in women (P<0.001).

Conclusion

The TG/HDLC ratio is significantly associated with metabolic syndrome.

Citations

Citations to this article as recorded by  
  • HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome
    Sebastià Alcover, Lisaidy Ramos-Regalado, Gabriela Girón, Natàlia Muñoz-García, Gemma Vilahur
    Antioxidants.2025; 14(4): 434.     CrossRef
  • Metabolic syndrome and related factors in Cameroonian women under contraceptive use
    Dandji Saah Marc Bertrand, Dangang Bossi Donald Séverin, Tanguenan Floraise Lynda, Zambou Ngoufack François, Ibrahim Sebutu Bello
    PLOS ONE.2024; 19(11): e0309054.     CrossRef
  • Association Between Triglycerides, High-Density Lipoprotein Cholesterol, and Their Ratio With the Pulse Wave Velocity in Adults From the ELSA-Brasil Study
    Deborah de Farias Lelis, Roberto S. Cunha, Raul D. Santos, Andrei C. Sposito, Rosane Härter Griep, Sandhi Maria Barreto, Maria del Carmen B. Molina, Maria Inês Schmidt, Bruce B. Duncan, Isabela Bensenor, Paulo Andrade Lotufo, José Geraldo Mill, Marcelo Pe
    Angiology.2023; 74(9): 822.     CrossRef
  • The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease
    Constantine E. Kosmas, Shanna Rodriguez Polanco, Maria D. Bousvarou, Evangelia J. Papakonstantinou, Edilberto Peña Genao, Eliscer Guzman, Christina E. Kostara
    Diagnostics.2023; 13(5): 929.     CrossRef
  • The Association between the Atherogenic Index of Plasma and Cardiometabolic Risk Factors: A Review
    Beatrice Lioy, Richard James Webb, Farzad Amirabdollahian
    Healthcare.2023; 11(7): 966.     CrossRef
  • Serum Asprosin Correlates with Indirect Insulin Resistance Indices
    Małgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kręgielska-Narożna, Paweł Bogdański, Wiesław Bryl, Maciej Owecki
    Biomedicines.2023; 11(6): 1568.     CrossRef
  • Lipid accumulation product is a better predictor of metabolic syndrome in Chinese adolescents: a cross-sectional study
    Zi-yi Chen, Lei Liu, Xu-xiu Zhuang, Yi-cong Zhang, Ya-nan Ma, Yang Liu, De-liang Wen
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Relationship between night shift and sleep problems, risk of metabolic abnormalities of nurses: a 2 years follow-up retrospective analysis in the National Nurse Health Study (NNHS)
    Heli Zhang, Jingpin Wang, Siwei Zhang, Sumei Tong, Jinping Hu, Ying Che, Lin Zhuo, Peng Wang, Rongmei Geng, Yujie Zhou, Panfeng Wang, Siyan Zhan, Baohua Li
    International Archives of Occupational and Environmental Health.2023; 96(10): 1361.     CrossRef
  • Association between Triglycerides to High-Density Lipoprotein Cholesterol Ratio and Death Risk in Diabetic Patients with New-Onset Acute Coronary Syndrome: A Retrospective Cohort Study in the Han Chinese Population
    Dongdong Shi, Le Wang, Hongliang Cong
    Reviews in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Predictive Value of the Triglyceride to High-Density Lipoprotein Cholesterol Ratio for All-Cause Mortality and Cardiovascular Death in Diabetic Patients With Coronary Artery Disease Treated With Statins
    Le Wang, Hongliang Cong, Jingxia Zhang, Yuecheng Hu, Ao Wei, Yingyi Zhang, Hua Yang, Libin Ren, Wei Qi, Wenyu Li
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study
    Deborah de Farias Lelis, João Vitor S. Calzavara, Raul D. Santos, Andrei C. Sposito, Rosane Härter Griep, Sandhi Maria Barreto, Maria del Carmen B. Molina, Maria Inês Schmidt, Bruce B. Duncan, Isabella Bensenor, Paulo Andrade Lotufo, José Geraldo Mill, Ma
    Journal of Clinical Lipidology.2021; 15(5): 699.     CrossRef
  • Triglyceride to high density lipoprotein cholesterol ratio may serve as a useful predictor of major adverse coronary event in female revascularized ST-elevation myocardial infarction
    Guo-xing Wan, Wen-bin Xia, Li-hua Ji, Hai-lun Qin, Yong-gang Zhang
    Clinica Chimica Acta.2018; 485: 166.     CrossRef
  • Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study
    Hyungseon Yeom, Hyeon Chang Kim, Ju-Mi Lee, Yongwoo Jeon, Il Suh
    Lipids in Health and Disease.2018;[Epub]     CrossRef
  • 5,852 View
  • 60 Download
  • 15 Web of Science
  • 13 Crossref
Serum Lipid Levels in Relation to Consumption of Yogurt: The 2012 Korea National Health and Nutrition Examination Survey
Bong-Kyung Seo, Nam-Eun Kim, Kyong-Min Park, Kye-Yeung Park, Hoon-Ki Park, Hwan-Sik Hwang
Korean J Fam Med 2017;38(5):249-255.   Published online September 22, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.5.249
Background

The purpose of this study was to evaluate serum lipid levels in Korean adults after consumption of different types of yogurt.

Methods

Study subjects were 3,038 individuals (≥19 years of age) who participated in the 2012 Korean National Health and Nutrition Examination Survey. Yogurt intake was assessed with a food frequency questionnaire by using the 24-hour recall method. We conducted complex samples general linear analysis with adjustment for covariates.

Results

The serum triglyceride levels in the group consuming viscous yogurt were lower than those in the group consuming non-viscous yogurt.

Conclusion

Consumption of viscous yogurt is associated with low serum triglyceride levels in Korean adults.

Citations

Citations to this article as recorded by  
  • Comparison and effect of plain and calcium fortified yogurt on glycemic responses, anthropometrics and metabolic biomarkers
    Asma Draz, Hafiza Madiha Jaffar, Bahisht Rizwan, Sadia Sukhera, Syeda Aiman Batool, Sana Noreen, Nazia Koser, Zeenat Islam
    Immunological Medicine.2024; 47(1): 30.     CrossRef
  • Effect of Yogurt Consumption on Metabolic Syndrome Risk Factors: a Narrative Review
    Leila Khorraminezhad, Iwona Rudkowska
    Current Nutrition Reports.2021; 10(1): 83.     CrossRef
  • 4,602 View
  • 54 Download
  • 2 Web of Science
  • 2 Crossref
Association between Hepatitis B Surface Antigen Seropositivity and Metabolic Syndrome
Tae-Heum Chung, Moon-Chan Kim, Chang-Sup Kim
Korean J Fam Med 2014;35(2):81-89.   Published online March 24, 2014
DOI: https://doi.org/10.4082/kjfm.2014.35.2.81
Background

Infection with hepatitis B virus (HBV) may be a risk factor for cardiovascular disease. We investigated the relationship between HBV infection and metabolic syndrome.

Methods

We performed a cross-sectional study of 9,474 Korean men and women who were at least 20 years old and who underwent a routine health check-up at Ulsan University Hospital in Ulsan, South Korea between March 2008 and February 2009. The associations of hepatitis B surface antigen (HBsAg) seropositivity with the presence of metabolic syndrome and its components were investigated by logistic regression analysis. Data were analyzed separately for males and females.

Results

HBsAg seropositivity was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in men (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.29 to 0.50; P < 0.001 and OR, 0.75; 95% CI, 0.57 to 0.98, P = 0.033). In women, HBsAg seropositivity was also significantly negatively associated with hypertriglyceridemia, but not with metabolic syndrome (OR, 0.40; 95% CI, 0.17 to 0.91; P = 0.029 and OR, 0.80; 95% CI, 0.38 to 1.66, P = 0.545).

Conclusion

HBV infection was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in men and hypertriglyceridemia in women.

Citations

Citations to this article as recorded by  
  • Systematic review: chronic viral hepatitis and metabolic derangement
    Chia‐Chi Wang, Pin‐Nan Cheng, Jia‐Horng Kao
    Alimentary Pharmacology & Therapeutics.2020; 51(2): 216.     CrossRef
  • Chronic hepatitis B-associated liver disease in the context of human immunodeficiency virus co-infection and underlying metabolic syndrome
    Edina Amponsah-Dacosta, Cynthia Tamandjou Tchuem, Motswedi Anderson
    World Journal of Virology.2020; 9(5): 54.     CrossRef
  • Canonical Correlation Between Self-Care Agency and Health-Related Self-Efficacy with Chronic Viral Hepatitis Patients
    HooJeung Cho, Euna Park
    Osong Public Health and Research Perspectives.2019; 10(5): 281.     CrossRef
  • Association between chronic hepatitis B infection and metabolic syndrome
    Xiaohui Zhao, Drishti Shah, Usha Sambamoorthi
    Journal of Diabetes & Metabolic Disorders.2018; 17(2): 223.     CrossRef
  • Hepatitis‐Viral

    Journal of Gastroenterology and Hepatology.2017; 32(S2): 65.     CrossRef
  • Unawareness of Hepatitis B Virus Infection confers on Higher Rate of Metabolic Syndrome: A Community-based Study
    Cheng-Hung Chien, Li-Wei Chen, Chih-Lang Lin, Su-Wie Chang, Yu-Chiau Shyu, Kuan-Fu Chen, Shuo-Wei Chen, Ching-Chih Hu, Chia-Ying Yu, Rong-Nan Chien
    Scientific Reports.2017;[Epub]     CrossRef
  • Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis
    Yuanyuan Li, Ying Zhao, Jianping Wu, Ferruccio Bonino
    PLOS ONE.2017; 12(5): e0177713.     CrossRef
  • Hepatitis B virus prevents excessive viral production via reduction of cell death-inducing DFF45-like effectors
    Jun Yasumoto, Hirotake Kasai, Kentaro Yoshimura, Teruhime Otoguro, Koichi Watashi, Takaji Wakita, Atsuya Yamashita, Tomohisa Tanaka, Sen Takeda, Kohji Moriishi
    Journal of General Virology .2017; 98(7): 1762.     CrossRef
  • Association of chronic hepatitis B infection with metabolic syndrome and its components: Meta-analysis of observational studies
    Bahman Razi, Shahab Alizadeh, Azadeh Omidkhoda, Danyal Imani, Ramazan Rezaei
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11: S939.     CrossRef
  • Occult Hepatitis B Virus Infection in Hyperlipidemia Patients
    Liu Yang, Tingting Li, Wenmin Li, Xi Tang, Jinfeng Li, Ruiwen Long, Yongshui Fu, Jean-Pierre Allain, Chengyao Li
    The Tohoku Journal of Experimental Medicine.2017; 241(4): 255.     CrossRef
  • Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study
    Hui Zeng, Hui Lin, Wenyi Liu, Jia Wang, Lingqiao Wang, Chuanfen Zheng, Yao Tan, Yujing Huang, Lixiong He, Jiaohua Luo, Chaowen Pu, Renping Zhang, Xiaohong Yang, Yingqiao Tian, Zhiqun Qiu, Ji-an Chen, Yang Luo, Xiaobin Feng, Guosheng Xiao, Liping Wu, Weiqu
    Scientific Reports.2017;[Epub]     CrossRef
  • Association between hepatitis B and metabolic syndrome: Current state of the art
    Peter Jarcuska
    World Journal of Gastroenterology.2016; 22(1): 155.     CrossRef
  • Relationship between chronic hepatitis B and metabolic syndrome: A structural equation modeling approach
    Chiao‐Yu Huang, Chia‐Wen Lu, Yi‐Lien Liu, Chien‐Hsieh Chiang, Long‐Teng Lee, Kuo‐Chin Huang
    Obesity.2016; 24(2): 483.     CrossRef
  • Chronic hepatitis B infection is not associated with increased risk of vascular mortality while having an association with metabolic syndrome
    Aezam Katoonizadeh, Shima Ghoroghi, Maryam Sharafkhah, Masoud Khoshnia, Samaneh Mirzaei, Amaneh Shayanrad, Hossein Poustchi, Reza Malekzadeh
    Journal of Medical Virology.2016; 88(7): 1230.     CrossRef
  • Hepatitis B virus infection and metabolic syndrome: Fact or fiction?
    Chia‐Chi Wang, Tai‐Chung Tseng, Jia‐Horng Kao
    Journal of Gastroenterology and Hepatology.2015; 30(1): 14.     CrossRef
  • 4,188 View
  • 25 Download
  • 13 Web of Science
  • 15 Crossref
Profile of serum lipoprotein in patients with subclinical hypothyroidism.
Wou Weon Lee, Chung Hwan Kim, Yoo Seock Cheong, Sun Mi Yoo, Il Hwan Park, Seouk Gun Park
J Korean Acad Fam Med 2000;21(3):376-381.   Published online March 1, 2000
Background
: Overt hyperthyroidism is a well-known cause of secondary hyperlipidemia and atherosclerosis. However, there have been some dissenting report of abnormalities and in serum lipid concentration in patients with subclinical hypothyroidism. We have attempted to analyze serum lipid concentrations to investigate whether they are increased in patients with subclinical hypothyroidism and to see if there is a correlation between serum LDL-C and TSH concentrations.

Methods : Serum lipid profiles(total cholesterol, triglycerides, LDL-C, HDL-C) of patients with subclinical hypothyroidism (M/F=7/119) compared with age, sex and body mass index matched control subject(M/F=14/239) from Jan. 1. 1996. to Dec. 30. 1997.

Results : There were no significant differences of serum total cholesterol, LDL cholesterol, TG, and HDL concentrations in 126 patients with subclinical hypothyroidism and 253 control subjects(178.47±35.76mg/Dl vs. 173.05±35.963mg/Dl ; 113.33±52.89mg/Dl vs.117.64±68.70mg/Dl ; 112.89±33.25mg/dL vs 109.65±29.02mg/Dl ; 48.60±11.34mg/Dl vs 46.51±11.73mg/Dl). There was no correlation between LDL cholesterol and TSH concentrations in subclinical hypothyroidism(r=0.29, p<0.05).

Conclusion : Serum lipid concentration(total cholesterol, LDL cholesterol, and TG, HDL) was not increased in patients with subclinical hypothyroidism. There was no correlation between serum LDL and TSH levels in patients with subclinical hypothyroidism.
  • 1,309 View
  • 8 Download
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