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"Vitamins"

Review Article

Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition
Susie Jung, Beom-Hee Choi, Nam-Seok Joo
Korean J Fam Med 2022;43(5):277-289.   Published online September 20, 2022
DOI: https://doi.org/10.4082/kjfm.21.0227
Identifying and preventing modifiable risk factors for cardiovascular disease is very important. Vascular calcification has been studied clinically as an asymptomatic preclinical marker of atherosclerosis and a risk factor for cardio-cerebrovascular disease. It is known that higher homocysteine levels are associated with calcified plaques and the higher the homocysteine level, the higher the prevalence and progression of vascular calcification. Homocysteine is a byproduct of methionine metabolism and is generally maintained at a physiological level. Moreover, it may increase if the patient has a genetic deficiency of metabolic enzymes, nutritional deficiencies of related cofactors (vitamins), chronic diseases, or a poor lifestyle. Homocysteine is an oxidative stress factor that can lead to calcified plaques and trigger vascular inflammation. Hyperhomocysteinemia causes endothelial dysfunction, transdifferentiation of vascular smooth muscle cells, and the induction of apoptosis. As a result of transdifferentiation and cell apoptosis, hydroxyapatite accumulates in the walls of blood vessels. Several studies have reported on the mechanisms of multiple cellular signaling pathways that cause inflammation and calcification in blood vessels. Therefore, in this review, we take a closer look at understanding the clinical consequences of hyperhomocysteinemia and apply clinical approaches to reduce its prevalence.

Citations

Citations to this article as recorded by  
  • Methionine synthetase A2756G and Cystathionine-β-synthase 844ins68 polymorphisms and coronary artery disease: A meta-analysis
    Yan-yan Li, Hui Wang, Yang-yang Zhang
    The American Journal of the Medical Sciences.2025; 369(5): 574.     CrossRef
  • Blood metabolites mediate causal inference studies on the effect of gut microbiota on the risk of vascular calcification
    Aoran Huang, Jianshuai Ma, Huijin Zhu, Yanli Qi, Yang Jin, Mingxuan Zhang, Li Yin, Minhong Luo, Sifan Chen, Chen Xie, Hui Huang
    Journal of Advanced Research.2025;[Epub]     CrossRef
  • Decoding post-myocardial infarction coronary microvascular dysfunction: The SP1-driven STAT3/KCa3.1/eNOS protective mechanism
    Zhen Wang, Yong Wang, Yan Cheng, Jingwen Zhang, Wenyang Nie, Xueqiang Liu, Hualiang Deng
    Cytojournal.2025; 22: 66.     CrossRef
  • Guidelines for nutrition counseling in primary healthcare clinics
    Gyeongsil Lee, Seung-Won Oh
    Journal of the Korean Medical Association.2024; 67(4): 278.     CrossRef
  • Plasma Homocysteine Levels as Cardiovascular Disease Risk vis-a-vis Estrogen Levels in Pre and Postmenopausal Women
    Likhitha Munnangi, K. S. S. Sai Baba, Noorjahan Mohammed, Oruganti Sai Satish, M. Vijaya Bhaskar, Siraj Ahmed Khan, N. N. Sreedevi, Bhavya Sirivelu
    Indian Journal of Cardiovascular Disease in Women.2024; 9: 143.     CrossRef
  • Impact of Hyperhomocysteinemia on Cytokine and Matrix Metalloproteinases Contents in Rat Skeletal Muscle
    Olha Kravchenko, Raksha Nataliia, Kostiuk Oleksandra, Liashevska Oleksandra, Tiron Oksana, Maievskyi Oleksandr
    Biomedical and Biotechnology Research Journal.2024; 8(3): 387.     CrossRef
  • Vitamin K and age-related diseases
    K. A. Eruslanova, Yu. S. Onuchina, E. V. Ivannikova, E. N. Dudinskaya
    Russian Journal of Geriatric Medicine.2023; (4): 236.     CrossRef
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  • 108 Download
  • 3 Web of Science
  • 7 Crossref
Original Article
Vitamin-Mineral Supplement Use Patterns in Elderly Koreans: Data from the 2007–2008 Korean National Health and Nutrition Examination Survey
So Young Park, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Hye Rim Hwang, Dong Wook Jeong, Young Hye Cho, Eun Jung Choi, Yu Hyeon Yi, Young Jin Tak, A Ra Jo, Seung Hoon Lee, Jeong Suk Jeon, Bo Wha Lee
Korean J Fam Med 2016;37(2):123-129.   Published online March 25, 2016
DOI: https://doi.org/10.4082/kjfm.2016.37.2.123
Background

Vitamin-mineral supplements are the most popular dietary supplements in Korea. However, few studies have assessed the relationship between vitamin-mineral supplementation and associated factors among the Korean elderly. The purpose of this study was to assess the use of vitamin-mineral supplements among elderly in Korea as well as its association with sociodemographic factors, health-related behaviors, medical conditions, and nutrient intake.

Methods

This study was based on data from the Korean National Health and Nutrition Examination Survey, conducted by the Korean Ministry of Health and Welfare from 2008 to 2009. Data from 3,294 elderly men and women (65 years of age and older) were analyzed. Multivariable-weighted logistic regression model analysis was used to evaluate the association between vitamin-mineral supplement use and sociodemographic factors, health-related habits, and medical conditions.

Results

Vitamin-mineral supplementation was reported by 16.3% of the participants. The most common reason for using dietary supplements was recommendations from friends and acquaintances. Highly educated person, female participants had a greater likelihood of taking vitamin-mineral supplements. In addition, analysis of nutrient intake from food sources alone revealed a lower proportion of vitamin-mineral supplement users with nutrient intakes below the estimated average requirements for vitamin A, vitamin C, thiamine, riboflavin, niacin, calcium, iron, and phosphorus, compared to nonusers. However, vitamin-mineral supplementation was not associated with health-related behaviors or medical conditions.

Conclusion

Highly educated person, elderly Korean women had a greater likelihood of using vitamin-mineral supplements. In addition, nutrient intakes from food sources alone were significantly higher among vitamin-mineral supplement users. Finally, vitamin-mineral supplementation may be an indicator of healthier diet in elderly Koreans.

Citations

Citations to this article as recorded by  
  • Effect of a Single Multi-Vitamin and Mineral Supplement on Nutritional Intake in Korean Elderly: Korean National Health and Nutrition Examination Survey 2018–2020
    Hyoeun Kim, Seung Guk Park
    Nutrients.2023; 15(7): 1561.     CrossRef
  • The Reason for Vitamin–Mineral Supplement Intake among Secondary School Adolescents in Malaysia and its Association with Nutritional Status and Dietary Practice
    Azli Baharudin, Fatimah Othman, Syafinaz Mohd Sallehuddin, Suhaila Abd Ghafar, Khairul Hasnan Amali, Norazizah Ibrahim Wong, Ahmad Ali Zainuddin
    Matrix Science Pharma.2023; 7(2): 52.     CrossRef
  • Prevalence of and Factors Associated With Nutritional Supplement Use Among Older Chinese Adults: A Nationwide Cross-Sectional Study in China
    Wanyue Dong, Zhonghe Sun, Ruhai Bai
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Vitamin, micronutrients and supplement prescribing patterns in a group of ambulatory colombian patients, 2016
    Manuel Enrique Machado-Duque, Juan Daniel Ayala-Torres, Jorge Enrique Machado-Alba
    Revista Médicas UIS.2020;[Epub]     CrossRef
  • Impact of diet-derived signaling molecules on human cognition: exploring the food–brain axis
    Raymond L. Rodriguez, John G. Albeck, Ameer Y. Taha, Kassandra M. Ori-McKenney, Gregg H. Recanzone, Tyler W. Stradleigh, Bronte C. Hernandez, Feng-Yao Vincent Tang, En-Pei Isabel Chiang, Lillian Cruz-Orengo
    npj Science of Food.2017;[Epub]     CrossRef
  • Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults
    Jeffrey Blumberg, Balz Frei, Victor Fulgoni, Connie Weaver, Steven Zeisel
    Nutrients.2017; 9(8): 849.     CrossRef
  • AVALIAÇÃO DA ROTULAGEM DE SUPLEMENTOS VITAMÍNICOS E/OU MINERAIS
    Andressa Barros Ibiapina, Monalisa de Alencar Lucena, Camila dos Reis Oliveira, Lucas Vaz de Castro Oliveira, Alessandra Braga Ribeiro
    Infarma - Ciências Farmacêuticas.2017; 29(1): 21.     CrossRef
  • 5,455 View
  • 38 Download
  • 4 Web of Science
  • 7 Crossref
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