Korean Journal of Family Medicine

"ferritin"

Original Articles

Association of Coffee or Green Tea with Ferritin or Hemoglobin in Premenopausal Women: Dagyeong Lee, Wonyoung Jung, Dong Wook Shin; Korean J Fam Med 2023;44(2):87-94. Published online March 20, 2023; DOI: https://doi.org/10.4082/kjfm.22.0133

Abstract
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Background
This study aimed to examine the association between coffee or green tea consumption and ferritin or hemoglobin levels in premenopausal women.
Methods
We used the fifth Korea National Health and Nutrition Examination Survey (2010–2012), and a total of 4,322 individuals were surveyed. In women of reproductive age, average ferritin and hemoglobin levels were calculated according to coffee or green tea consumption. Covariates included in the analysis were demographic variables, such as age, body mass index, education, drinking, smoking, history of hypertension, history of diabetes diagnosis, physical activity, total energy intake, and daily iron intake.
Results
In 4,322 participants, the average hemoglobin level was 12.90±0.02 g/dL, and the average level of ferritin was 31.95±0.67 ng/mL. As a result of testing, correlation between ferritin and coffee intake and difference in ferritin levels according to coffee consumption was significant (P<0.05). In this study, a post hoc test indicated that ferritin level significantly differed between one and two cups, two and three cups, and three and one cup groups (overall P<0.001). Additionally, there was a negative correlation between ferritin level and coffee intake; ferritin level decreased by 2.09 ng/mL with a one-cup increase in daily coffee consumption.
Conclusion
In premenopausal women, coffee intake is associated with low serum ferritin levels. Our results indicate that drinking >2 cups of coffee significantly affect ferritin levels in Korean premenopausal women.

Citations

Citations to this article as recorded by

Women’s Health and Primary Care
Seung-Won Oh
Korean Journal of Family Medicine.2024; 45(1): 1. CrossRef
Guidelines for nutrition counseling in primary healthcare clinics
Gyeongsil Lee, Seung-Won Oh
Journal of the Korean Medical Association.2024; 67(4): 278. CrossRef
Dietary diversity and preferences among pregnant women and its association with anaemia
Benedicta Twum - Dei, Richmond Aryeetey, Linda Nana Esi Aduku
Nutrition & Food Science .2024; 54(4): 805. CrossRef
Association Between Tea Drinking and Anemia in Women of Reproductive Age: A Cross-Sectional Study From the Mekran Division, Balochistan, Pakistan
Noman Sadiq, Yasmeen Gul, Muhammad M Bilal, Muhammad Afzal, Nasrin Mumtaz, Abdul Wahid
Cureus.2024;[Epub] CrossRef
Does tea intake increase the risk of anemia? Evidence from a large prospective cohort and Mendelian randomization study
Rui Hang Zhang, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Shiu Lun Au Yeung, Tai Hing Lam, Lin Xu, Jiao Wang
Food & Function.2024; 15(18): 9552. CrossRef
A Comparative Study of the Effect Coffee and Tea on Some Parameters in the Rats Blood
Sadiq Al-Mansury, Suhad J. Hadi, Hawraa H. Naji, Adnan M. Jassim, Shatha M. Abbas, Nada Khazal K. Hindi
Medical Journal of Babylon.2024; 21(3): 627. CrossRef
Association between Coffee and Green Tea Consumption and Iron Deficiency Anemia in Korea
Jungun Lee
Korean Journal of Family Medicine.2023; 44(2): 69. CrossRef

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Association between Serum-Ferritin Levels and Sleep Duration, Stress, Depression, and Suicidal Ideation in Older Koreans: Fifth Korea National Health and Nutrition Examination Survey 2010–2012: Kyung Mi Kim, Hye Rim Hwang, Yun Jin Kim, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Sung In Chung; Korean J Fam Med 2019;40(6):380-387. Published online November 20, 2019; DOI: https://doi.org/10.4082/kjfm.18.0097

Abstract
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Background
Serum-ferritin levels may be associated with psychiatric symptoms among the elderly; however, this association has not been extensively studied. The aim of this study was to evaluate the association between serumferritin levels and mental health issues in older Koreans.
Methods
This cross-sectional study included large-scale national data from the Korea National Health and Nutrition Examination Survey 2010–2012. In total, 1,802 older Koreans (≥65 years old) were included. The assessed psychiatric symptoms included short sleep duration, stress, depressed mood, and suicidal ideation. Any association between serum-ferritin levels and mental health issues according to sex was examined using logistic regression analysis.
Results
The prevalence of short sleep duration, stress, depressed mood, and suicidal ideation was 50.9%, 21.7%, 18.2%, and 22.5%, respectively. In men, suicidal ideation decreased with increased serum-ferritin levels after multivariate adjustment for sociodemographic and lifestyle factors and comorbidities. The odds ratios (OR) and 95% confidence interval (CI) of suicidal ideation by quartiles of serum-ferritin level were 1 (reference), 1.132 (95% CI, 0.569–2.252), 0.453 (95% CI, 0.217–0.945), and 0.608 (95% CI, 0.295–1.253), respectively, (P for trend=0.039). In women, no trend was observed. However, compared to the lowest quartile, short sleep duration (<7 h) and stress perception were significantly decreased in the third quartile, with odds ratios of 0.601 (95% CI, 0.461–0.888), and 0.606 (95% CI, 0.386–0.952), respectively.
Conclusion
Moderate serum-ferritin levels were associated with decreased risk for suicide ideation in men, and were associated with decreased short sleep duration and stress perception in women.

Citations

Citations to this article as recorded by

Association between suicide attempts and anemia in late-life depression inpatients
Jie Li, Lan Wang, Ziyi Wang, Fengxue Zhao, Yadi Sun, Ying Lu, Lei Yang
BMC Geriatrics.2024;[Epub] CrossRef
Sleep quality and Laboratory Findings in Patients with Varicose Vein Leg Pain
Acır Ibrahim, Atay Zeynep Vildan Okudan , Atay Mehmet , Yayla Vildan
Journal of Neuroscience and Neurological Disorders.2023; 7(1): 022. CrossRef
Alteration of Inflammatory Parameters and Psychological Post-Traumatic Syndrome in Long-COVID Patients
Irma Clemente, Gaia Sinatti, Antonio Cirella, Silvano Junior Santini, Clara Balsano
International Journal of Environmental Research and Public Health.2022; 19(12): 7103. CrossRef
Psychological and Cognitive Effects of Long COVID: A Narrative Review Focusing on the Assessment and Rehabilitative Approach
Rosaria De Luca, Mirjam Bonanno, Rocco Salvatore Calabrò
Journal of Clinical Medicine.2022; 11(21): 6554. CrossRef
Suicidal Ideation in Major Depressed Individuals: Role of Type D Personality
Mokhtar Abdelhakim Laoufi, Benjamin Wacquier, Tristan Lartigolle, Gwenolé Loas, Matthieu Hein
Journal of Clinical Medicine.2022; 11(22): 6611. CrossRef

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Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women: Jee-Yon Lee, Jae-Min Park, Jung-Ah Hong, Duk-Chul Lee, Jee-Aee Im, Ji-Won Lee; Korean J Fam Med 2012;33(4):205-210. Published online July 25, 2012; DOI: https://doi.org/10.4082/kjfm.2012.33.4.205

Abstract
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Background

Ferritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women.

Methods

We evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years.

Results

In all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group.

Conclusion

Our findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity.

Citations

Citations to this article as recorded by

Gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults
Hyun Yoon, Yoon Sik Kim, Jun Ho Lee, Mi Young Gi, Ju Ae Cha, Jeong Min Seong, James Fielding Hejtmancik
PLOS ONE.2018; 13(6): e0199465. CrossRef
Serum ferritin level as an early indicator of metabolic dysregulation in young obese adults — a cross-sectional study
Harshitha Hitha, Damodara Gowda, Amrit Mirajkar
Canadian Journal of Physiology and Pharmacology.2018; 96(12): 1255. CrossRef

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The Relationship between Serum Ferritin and High Sensitivity C-reactive Protein among Adults in a Health Promotion Center .: Eun Sil Oh, Hyun Sik Shin, Ji Won Lee, Ji Ae Lim, Duk Chul Lee, Hye Ree Lee; J Korean Acad Fam Med 2008;29(12):908-914. Published online December 10, 2008

Abstract
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Background: More attention is given to oxidative hypothesis which causes atherosclerosis to be recognized as inflammatory response. The relationship between serum ferritin which catalyzes lipid peroxidation and high sensitivity C-reactive protein which reflects vascular inflammation was investigated among adults in a health promotion center. Methods: The study group consisted of 297 men and women (men 86, women 211) who visited the health promotion center of a hospital in Seoul to have a health checkup from October 1, 2004 to April 1, 2005. These subjects answered the questionnares and were measured in the following; blood tests, brachial-ankle pulse wave velocity and several anthropometric measurements. Statistical analysis was performed on 111 subjects after exclusion of those subjects who were taking antihypertensive agents or antidiabetic agents, and who had acute inflammatory diseases, acute liver diseases, anemia, and who had a WBC ≥11,000×10³/mm³or a serum ferritin ≥200 ug/L or a ABI (Ankle Brachial Index) <0.9. Results: The average serum ferritin concentration of men against women was 132.57±43.12 ng/ml to 78.23±38.10 ng/ml which means that men have about 1.7 times as high concentration than women (P<0.001). Serum ferritin was significantly correlated with high sensitivity C-reactive protein (r=0.332). Even in multiple stepwise regression analysis, there was a independent relationship between serum ferritin and high sensitivity C-reactive protein (Ղ=0.138, P=0.010). When we analyzed with distinction of sex, this relationship in women was constant (Ղ=0.131, P=0.031), but serum ferritin in men just showed the trend of correlation with BMI (Ղ=9.510, P=0.059). Conclusion: There is a significant relationship between the increase of serum ferritin and high sensitivity C- reactive protein in healthy women; furthermore, studies in men need to be confirmed. (J Korean Acad Fam Med 2008;29:908-914)

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Case Report

Adult Onset Still's Disease.: Dong Hwan Lee, Jeung Woong Park, Ji Won Hyun, Dae Hyun Kim, Young Sung Suh; J Korean Acad Fam Med 2007;28(3):210-213. Published online March 10, 2007

Abstract
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Adult onset Still's disease (AOSD) is an uncommon acute systemic inflammatory disease of unknown origin. The clinical features include high spiking fever, arthralgia or arthritis, transient maculopapular rash, lymphadenopathy, hepatosplenomegaly, and serositis. The laboratory findings include leukocytosis(neutrophilia), elevation of AST, ALT, ESR, CRP and serum ferritin, and negative rheumatic factor and anti-nuclear antibody. We report a case of a 52-year old woman whom symptom is subsided after steroid use. (J Korean Acad Fam Med 2007;28: 210-213)

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Original Articles

Relationship between Serum gamma-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults.: Jung Ha Kim, Hye Ree Lee, Ah Reum Han, Jee Aee Im, Duk Chul Lee; J Korean Acad Fam Med 2006;27(8):645-651. Published online August 10, 2006

Abstract
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Background
: Serum γ-GT is one of the biliary enzymes with the only enzymatic activity capable of cleaving extracellular glutathione, thus originating precursor amino acids for the intracellular resynthesis of glutathione. Several population-based studies have shown a strong cross-sectional association between serum γ-GT concentration and cardiovascular risk factors. And prospective studies showed that serum γ-GT concentration had a prognostic impact on cardiovascular mortality. But, the mechanism by which γ-GT is associated with cardiovascular disease is not elucidated. We hypothesized that there was an association between serum γ-GT and ferritin, a marker of oxidative stress. In this study, we investigated the relationship between serum γ-GT and serum ferritin.

Methods : By reviewing the medical records of 288 healthy adults, we determined the serum levels of γ-GT and ferritin according to age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL-cholesterol, fasting blood sugar, hs-CRP, serum ferritin, AST, ALT, uric acid and smoking history. We studied the relationship between the variables by Pearson correlation coefficients and multiple stepwise regression analysis. Mean values of serum γ-GT according to the smoking history were compared using t-test.

Results : Serum γ-GT correlated positively with serum ferritin (r=0.42; P＜0.001). BMI, triglycerides, total cholesterol, fasting blood sugar, AST and ALT also showed statistically significant correlation. Smokers showed significantly higher serum γ-GT. Serum γ-GT correlated with serum ferritin, ALT, current smoking and triglycerides by multiple stepwise regression analysis.

Conclusion : Serum γ-GT correlated positively with serum ferritin.

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Relationship of Serum Ferritin with Cardiovascular Risk Factors.: Ah Reum Han, Kil Young Kwon, Sang Hwan Kim, Ji Ae Lim, Duk Chul Lee, Hye Ree Lee; J Korean Acad Fam Med 2006;27(5):358-363. Published online May 10, 2006

Abstract
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Background
: Sullivan has suggested that higher incidence of coronary heart disease in men and postmenopausal women is due to higher levels of stored iron in these two groups. A few epidemiologic studies in humans have reported the association between iron stores and increased risk of cardiovascular diseases. But there is conflicting evidence regarding the relationship between iron and cardiovascular diseases. The present study evaluated the relationship between ferreting and well established cardiovascular risk factors.

Methods : There were 288 healthy subjects who visited a health promotion center of a general hospital. We collected data by means of self-reported questionnaire and measured height, weight and blood pressure. Serum ferritin, fasting blood glucose, lipid profiles, and C-reactive protein were measured at a fasting state.

Results : Mean serum ferritin values were 150.1±82.2 ng/mL in men and 61.7±38.2 ng/mL in women (P＜0.001). Serum ferritin level in current smoker was higher than in non-smoker (157.6±111.8 ng/mL versus 100.5±64.2 ng/mL, P=0.006). Serum ferritin was significantly and positively correlated with body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol and triglyceride. There was no statistical significance in age, C-reactive protein, high- density lipoprotein cholesterol and low-density lipoprotein cholesterol. In multiple regression analysis, there was association between ferritin and sex (β=-80.333, P＜0.001) and triglycerides (β=0.182, P=0.030).

Conclusion : The serum ferritin level in men is higher than in women in healthy adults. Serum ferritin is positively associated with triglycerides.

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Diabetes mellius and serum ferrtin concentration.: Seung Heon Han, Sa Rah Lee, Jeong Ho Choi, Jun Hyun Yoo; J Korean Acad Fam Med 2001;22(11):1630-1636. Published online November 1, 2001

Abstract
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Background
: A prospective study about the association between serum ferritin concentration and diabetes mellitus showed that higher risk of diabetes was found in men in higher concentration of serum ferritin. The aims of this study is to examine the association between serum ferritin concentration and the risk of diabetes mellitus in healthy Korean in hospital-based samples.

Methods : In a volunteered healthy population(n=14.782), who underwent health examination in Samsung Medical Center, from January to December 1997, serum ferritin and glucose were determined.

Results : After adjusting for age, BMI, serum triglyceride concentration, and multiple logistic regression analysis showed that those in the highest quartile had increased risk of diabetes mellitus (OR: men 2.26(95% CI 2.41-2.95, p=0.0001), women 3.03(95% CI 2.51-3.67, p=0.0001), compared with those in the lowest quartile.

Conclusion : In studied population, elevated serum ferritin concentration was associated with an increased risk of diabetes.