Background
Chronic atrophic gastritis causes hypochlorhydria, hypergastrinemia, and malabsorption of nutrients, leading to lower bone mineral density. The few studies that investigated the association between chronic atrophic gastritis and bone mineral density have reported inconsistent findings. As such, the present study assessed the association between chronic atrophic gastritis and bone mineral density among a large sample of women >40 years of age in Korea.
Methods
Data from 8,748 women >40 years of age who underwent esophagogastroduodenoscopy and bone densitometry were analyzed. Chronic atrophic gastritis was diagnosed using esophagogastroduodenoscopy. Bone mineral density of the lumbar vertebrae (L), femur neck, and femur total, measured using dual-energy X-ray absorptiometry, were the primary outcome variables. Low bone mineral density, which could be diagnosed as osteoporosis or osteopenia, was defined and analyzed as a secondary outcome. Linear regression was used to calculate adjusted mean values of bone mineral density. The association between low bone mineral density and chronic atrophic gastritis was analyzed using multiple logistic regression.
Results
The adjusted mean bone mineral density for L1–L4 was 1.063±0.003, femur neck (0.826±0.002), and femur total (0.890±0.002) were significantly lower in patients with chronic atrophic gastritis than others (1.073±0.002, 0.836±0.001, 0.898±0.002, respectively; all P<0.01). Women with chronic atrophic gastritis exhibited an increased likelihood for osteopenia or osteoporosis, even after adjusting for age and other confounding factors (odds ratio, 1.25; 95% confidence interval, 1.13–1.40; P<0.01). However, subgroup analysis revealed statistical significance only in postmenopausal women (odds ratio, 1.27; P<0.001).
Conclusion
Chronic atrophic gastritis was associated with lower bone mineral density and a higher risk for osteopenia or osteoporosis among postmenopausal women.

Citations

• Association between gastric polyps and decreased bone mineral density in patients with chronic gastritis
  Guotao Liu, Jianyuan Zhang
  Scientific Reports.2025;[Epub]     CrossRef
• The Interconnected Nature of Smoking, Depression, and Obesity in Behavioral Medicine
  Joung Sik Son
  Korean Journal of Family Medicine.2024; 45(4): 181.     CrossRef

Citations

• A Comparative Pharmacokinetic Study of Fexuprazan 10 mg: Demonstrating Bioequivalence with the Reference Formulation and Evaluating Steady State
  Wonsuk Shin, A-Young Yang, Hyung Park, Hyejung Lee, Hyounggyoon Yoo, Anhye Kim
  Pharmaceuticals.2023; 16(8): 1141.     CrossRef
• Verrucous antral gastritis in relation to Helicobacter pylori infection, nutrition, and gastric atrophy
  Naoko Tsuji, Yasuko Umehara, Mamoru Takenaka, Yasunori Minami, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo
  Gastroenterology Report.2020; 8(4): 293.     CrossRef
• PROFIL PENGETAHUAN MAHASISWA INSTITUT TEKNOLOGI SEPULUH NOPEMBER TERHADAP PENGGUNAAN OBAT ANTASIDA
  Ersalia Susetyo, Ermawati Dwi Agustin, Hurindina Hanuni, Rafiqa Amalia Chasanah, Elda Yuliana Dwi Lestari, Rana Rana, Yehezkiel Alfa Ludji Leo, Zulfia Almas Rizqulloh, Galina Meldaviati, Jamilatul Fardha, Ferri Febriansyah, Didy Pratama Maylana Susanto, F
  Jurnal Farmasi Komunitas.2020; 7(2): 48.     CrossRef
• Association between self-reported eating speed and metabolic syndrome in a Beijing adult population: a cross-sectional study
  Lixin Tao, Kun Yang, Fangfang Huang, Xiangtong Liu, Xia Li, Yanxia Luo, Lijuan Wu, Xiuhua Guo
  BMC Public Health.2018;[Epub]     CrossRef

Background
The reports that obesity could be associated with upper gastrointestinal disorders such as gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis have not been consistent. Therefore, we studied the association between esophagogastroduodenoscopic (EGD) fi ndings and the related risk factors of obesity. Methods: The study subjects include 2,210 adults who visited the Health Promotion Center of one university hospital from January 2006 to December 2006. All subjects had standard physical measurements as well as resting blood pressure, fasting blood glucose, HbA1c, serum lipids, and gastroendoscopic examination. BMI was classifi ed into two groups (BMI ≥ 23 kg/m2, normal; BMI < 23 kg/m2, overweight or obese). The study subjects were classifi ed into four groups according to the EGD fi ndings; normal, gastritis, gastric or duodenal ulcer, refl ux esophagitis. Results: Mean BMI of gastritis, gastric or duodenal ulcer, and refl ux esophagitis groups were higher than normal group after adjusting age, sex, alcohol and smoking (P < 0.001). Gastritis risk (OR, 2.098; 95% CI, 1.195 to 3.682; P = 0.01), gastric or duodenal ulcer risk (OR, 2.562; 95% CI, 1.282 to 5.117; P = 0.008), and refl ux esophagitis risk (OR, 2.856; 95% CI, 1.522 to 5.360; P = 0.001) were signifi cantly higher in overweight and obesity group compare with normal weight group after adjusting age, sex, alcohol and smoking. Conclusion: We suggest that overweight or obesity is the risk factor of gastritis, gastric or duodenal ulcer, and reflux esophagitis.

Background
: Upper gastrointestinal diseases are relatively important in Korea. There are various studies on upper gastrointestinal diseases, especially relationships with Helicobacter pylori, but studies on young adults are relatively fewer. Therefore, we conducted this study in order to know the prevalence of various upper gastrointestinal diseases and the association with Helicobacter pylori among young policemen.

Methods : Diagnosis and classification of upper gastrointestinal diseases were made in 260 policemen, who visited the outpatient department of family medicine at one general hospital in Seoul from March 2, 2001 to December 31, 2002.

Results : The frequencies of upper gastrointestinal diseases were gastritis (62.2%), duodenal ulcer (14.4%), gastric ulcer (7.5%), duodenitis (6.9%), and no active lesion (9.0%). The frequency of multiple upper gastrointestinal disease was chronic superficial gastritis and duodenal ulcer (37%), chronic superficial gastritis and duodenitis (21.9%), and acute gastritis and duodenal ulcer (16.4%), and these groups comprised the most with 75.3%. The location of the lesion was found at antrum (62.2%) and duodenum (21.6%). Ulcer stages in gastric and duodenal ulcer were mostly in active stage. Helicobacter pylori infection in gastric and duodenal ulcer were 36% and 85.4%, respectively.

Conclusion : Most symptomatic patients had lesions which were found at antrum and duodenum as in other studies. Ulcer diseases in duodenum were much more frequent than those in stomach, which probably be associated with Helicobacter pylori. Therefore, suitable examination and treatment are necessary.

Background
: Helicobacter pylori has been known to be not only associated with gastrointestinal diseases but also to be reported in several cases of increased incidence of anemia. The anemia associated with H. pylori infection was reported though the population studies and case reports. But in Korea, there have been not enough studies especially in adults group, so we investigated to find out if H. pylori infection is associated with anemia in adults with gastritis.

Methods : Subjects were 382 men older than 40 years and 158 postmenopausal women, who had visited a general hospital for physical examination from May 2001 to October 2001 and diagnosed as only gastritis. Data were analysed for the effects of H. pylori infection on anemia using logistic regression test.

Results : In men, Pearson correlation coefficients between age and hemoglobin, and hematocrit were -0.163, -0.136, respectively (P＜0.01). In women, Pearson correlation coefficients between age and hemoglobin, and hematocrit were 0.180 (P＜0.05), 0.031 (P＞0.05) respectively. Logistic regression analysis adjusted for age showed the lower odds ratio for anemia in both men and women without H. pylori than in those with H. pylori, but it was not significant.

Conclusion : H. pylori infection seems not to affect hemaglobin and hematocrit in the middled-aged men and the postmenopausal women with gastritis. Further investigations will be necessary for various individuals including infants and premenopausal women who may have high incidence for anemia.