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Journal of the Korean Academy of Family Medicine 1991;12(1):1-7.
Published online January 1, 1991.
Lipid-lowering effect of omega-3 fatty acid in patients with hypercholesterolemia.
Seung Nam Lee, Hoon Ki Park, Yong Eun Kim, In Hong Hwang, Bong Yul Huh
omega 3 - 지방상 제제가 고지혈증에 미치는 효과
허봉렬, 황인홍, 박훈기, 김용은, 이승남
서울대학교병원 가정의학과
Abstract
Hyperlipidemia has long been associated with cardiovascular disorders by increased incidence of artherosclerosis. So it remains one of the chief risk factors accociated with coronary artery disease and cerebrovascular accidents.
In Korea, there is a increased tendency of hyperlipidemia because of increased ingestion of animal fat, which may account for increased incidence of cardiovascular disease.
It was revealed that the low prevalence of artherosclerosis and cardiovascular disease among Eskimos in Greenland despite a diet as high in fat and cholesterol as that of the Danes or American resulted from different composition of fat consumed, which contained much higher proportion of omege-3 polyunsaturated fatty acids in the fish diet. The omega-3 fatty acids have lowering effect of serum lipid level. Among the 44 hypercholesterolemic patients who visited Family Practice Center, the randomly selected 26 patients took 650mg omega-3 fatty acid daily and their serum lipid levels were compared with those of the control group. In the case group. omega-3 fatty acids led to decrease in plasma cholesterol (8.2per cent), triglyceride (18.2 per cent), and low density lipoprotein (9.8 per cent). There was no side effect. In the control group. it had much less effect. We conclude that omega-3 fatty acids have lipid lowering effect in hyperlipidemic patients, especially with hypertriglyceridemia.


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