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Korean J Fam Med > Volume 30(1); 2009 > Article
Korean Journal of Family Medicine 2009;30(1):23-30.
DOI: https://doi.org/10.4082/kjfm.2009.30.1.23    Published online January 10, 2009.
Association of Serum Gamma Glutamyltransferase and Fasting Blood Glucose among Middle Aged and Elderly in Chuncheon: Hallym Aging Study.
Jung Su Lim, Young Ho Choi, Jin Young Jeong, Soong Nang Jang, Yoo Sun Moon, Jung Hun Kim, Eun Shin Kwak, Moon Gi Choi, Kyung Soon Hong, Dong Hyun Kim
1Department of Family Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
2Department of Endocrinology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
3Department of Cardiology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
4Department of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, Korea. dhkims@hallym.ac.kr
5Hallym Research Institute of Clinical Epidemiology, Chuncheon, Korea.
6Deptartment of Society, Human Development and Health, Harvard School of Public Health, Boston, USA.
춘천 지역 중년 및 노인에서의 혈청 감마지티피와 공복혈당장애의 유병률과의 상관관계: 한림노년연구
임정수, 최영호, 정진영, 장숙랑, 문유선, 김정훈, 곽은신, 최문기, 홍경순, 김동현
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Abstract
Background
Serum gamma-glutamyltransferase (GGT) was reported to be associated with type 2 diabetes, many cardiovascular disease risk factors, and individual components of metabolic syndrome. We performed a cross-sectional study to elucidate the relations between GGT and impaired fasting glucose (IFG). Methods: The subject of this study included 693 adults (males 272, females 421) aged 45 years or over who have lived in Chuncheon, suburban small-sized city. IFG was defined by an elevated fasting plasma glucose (FPG) concentration (≥100 and < 126 mg/dl). Results: The risk of IFG appeared to increase with increasing levels of serum GGT even after adjusting for other covariates, such as body mass index and inflammatory markers among men only: Adjusted odds ratios of IFG across GGT categories (<25th, <50th, <75th and ≥75th) were 1.0, 0.56, 1.57, 2.79. (p-value for trend 0.022). In women, the association between the risk of IFG and GGT was not statistically significant. Conclusion: This study suggests that elevated level of GGT within the normal range is a independent predictor of impaired fasting glucose in middle-ages or older men but not in women.
Key Words: Gamma-glutamyltransferase; Impaired fasting glucose; Insulin resistance


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