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Journal of the Korean Academy of Family Medicine 2008;29(9):651-657.
Published online September 10, 2008.
Fasting Plasma Glucose Levels and Metabolic Syndrome in Normoglycemic Adults.
Jae Kyung Choi, Youl Lee Lym, Seung Won Oh, Jin Ho Park, Cheol Min Lee, Sang Ho Yoo, Yeol Kim
1Department of Family Medicine, School of Medicine, Konkuk University, Seoul, Korea. cjk@konkuk.ac.kr
2Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.
3Department of Family Medicine, Hallym University College of Medicine, Chuncheon, Korea.
4Department of Family Medicine, Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea.
정상 공복혈당을 보이는 성인에서 공복혈당치와 대사증후군
최재경,임열리,오승원,박진호,이철민,유상호,김열
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Abstract
Background
Metabolic syndrome has been introduced to increase the incidence of cardiovascular diseases and type 2 diabetes mellitus. Our aim of this study was to investigate the association of fasting plasma glucose levels and metabolic syndrome in normoglycemic adults. Methods: We examined lifestyle factors, anthropometric and laboratory measurement of adults with no personal history of diabetes and normal fasting glucose from the Korean National Health and Nutrition Examination Survey 2001. We categorized the fasting plasma glucose levels below 100 mg/dl into the quintiles and assessed the association of metabolic syndrome with increasing glycemia in normoglycemic adults. Results: Quintiles of normal fasting plasma glucose levels showed a positive trend with metabolic risk factors including abdominal obesity, high blood pressure, and obesity in normoglycemic adults (P<0.001). Hypertriglyceridemia, low HDL-cholesterolemia, smoking, heavy drinking, and physical activity were of no significance. A multivariate model, adjusted for age, sex, smoking status, physical activity, and heavy drinking, revealed a progressively increased odds ratio of metabolic syndrome, 1.05 (95% CI, 0.76∼1.44), 1.15 (95% CI, 0.84∼1.58), 1.33 (95% CI, 0.99∼1.80), 1.55 (95% CI, 1.14∼2.10), with increasing fasting plasma glucose levels, as compared with fasting plasma glucose level of 81 mg/dl or less (P<0.001). Conclusion: Higher fasting plasma glucose levels within the normoglycemic range may constitute a risk of metabolic syndrome in normoglycemic adults. (J Korean Acad Fam Med 2008;29:651-657)
Key Words: normal fasting plasma glucose, metabolic risk factor, metabolic syndrome
초록
연구배경: 대사증후군은 심혈관질환과 제2형 당뇨병의 발생을 증가시키는 것으로 알려져 있다. 본 연구에서는 정상 공복혈당을 보이는 성인에서 공복혈당치와 대사증후군의 관계를 살펴보고자 하였다. 방법: 2001년 국민건강영양조사의 자료를 이용하여 당뇨병의 과거력이 없고 정상 공복혈당 범위 내에 있는 성인을 대상으로 신체계측과 혈액검사, 생활요인의 조사를 실시하였다. 100 mg/dl 미만의 정상 공복혈당을 보이는 성인을 공복혈당치에 따라 5개 군으로 나누어 공복혈당치 증가와 대사증후군의 관계를 분석하였다. 결과: 정상 공복혈당을 보이는 성인에서 공복혈당치가 증가할수록 대사위험인자 중 복부비만, 높은 혈압, 비만이 증가하는 경향을 보였고(P<0.001), 고중성지방혈증, 저고밀도콜레스테롤혈증과 생활요인인 흡연, 음주, 운동은 유의성이 없었다. 대사증후군은 나이, 성별, 흡연, 음주, 운동 등을 보정하여 분석하였을 때 공복혈당≤81 mg/dl인 군에 대해서 공복혈당치가 증가할수록 교차비가 1.05 (95% CI, 0.76∼1.44), 1.15 (95% CI, 0.84∼1.58), 1.33 (95% CI, 0.99∼1.80), 1.55 (95% CI, 1.14∼2.10)로 증가하는 경향을 보였으며 이는 통계적으로 유의하였다(P<0.001). 결론: 공복혈당이 정상인 성인에서도 공복혈당치가 증가할수록 대사증후군의 위험이 증가할 수 있다
중심 단어: 정상 공복혈당, 대사위험인자, 대사증후군


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