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Korean J Fam Med > Volume 31(4); 2010 > Article
Korean Journal of Family Medicine 2010;31(4):308-313.
DOI: https://doi.org/10.4082/kjfm.2010.31.4.308    Published online April 20, 2010.
A Case Report of Anti-Neutrophil Cytoplasmic Antibodies Negative Churg-Strauss Syndrome.
Seung Beom Lee, Hee Cheol Kang, Jun Jeong Choi
1Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea. kanghc@yuhs.ac
2Department of Pathology, Severance Hospital, Seoul, Korea.
항호중구 세포질 항체 음성인 Churg-Strauss 증후군 1예
이승범, 강희철, 최준정
1
2
Abstract
Churg-Strauss syndrome is a rare primary vasculitis called allergic granulomatosis angiitis. There is a substantial overlap of symptoms or signs between different vasculitides, so that a diagnosis of any vasculitis can be determined by a combination of clinical symptoms and laboratory tests. We report a case of a 54-year-old woman who had bronchial asthma, eosinophilia, peripheral polyneuropathy, pulmonary infiltrate, maxillary sinusitis, and extravascular eosinophilic infiltration on skin biopsy. So she was diagnosed as having Churg-Strauss syndrome, but she was antineutrophil cytoplasmic antibodies-negative on immunologic study. She had fever and showed cardiac involvement that was presented as cardiomegaly and pulmonary edema at chest radiography and left ventricular hypertrophy on electrocardiography. After steroid therapy, general condition and skin manifestation were rapidly improved.
Key Words: Churg-Strauss Syndrome; Vasculitis; ANCA


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