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Journal of the Korean Academy of Family Medicine 2000;21(7):914-921.
Published online July 1, 2000.
The Clinical study for Efficacy and Safety of Amezinium methylsulfate.
Kang Eun Lim, Kwang Joon Jun, Hee Jeong Koh, Sung Kwon Hong, Yu Jin Paek, Taiwoo Yoo
Department of Family Medicine, Seoul National University Hospital, Korea.
저혈압 치료제 Amezinium methylsulate ( 리스믹 ) 의 효과 및 안전성에 관한 연구
고희정, 유태우, 임강은, 전광준, 홍승권, 백유진
서울대학교 의과대학 가정의학교실
Abstract
Background
: Amezinium methylsulfate(Risumic) is the useful drug in the treatment of essential hypotension. This drug elevate blood pressure by stimulating sympathetic nervous system and improve symptoms related hypotension. This study was designed to evaluate efficacy and safety of Risumic for patients with essential hypotension.

Methods : This study was performed in patients with systolic blood pressure less than 100mmHg from June, 1999 to December, 1999. Risumic blood pressure response, improvement of symptom and side effect were examined in a double-blind, placebo-controlled, crossover trial.

Results : Total of 54 patients participated in this study and only 55.6% of them were finished and the rest of them(44.4%) was stopped. 6 patients of this patients were stopped because of side effects. But there was no difference in side effects in Risumic and placebo periods. In diastolic BP, Risumic group is 5mmHg higher than placebo group. And then there was significant difference in statistics.

Conclusion : In essential hypotensive patients, Risumic is elevater DBP than SBP, side effects frequency was no significant difference in Risumic and placebo group.
초록
연구배경 : Amezinium methylsulfate(리스믹)
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