Background
Current guidelines for the treatment of hyperlipidemia propose lifestyle modification as a first-line intervention. The aim of this study was to identify the factors which determine responsiveness of LDL-cholesterol lowering to lifestyle modifi cation in hypercholesterolemic patients.Methods: A total of 109 patients aged between 30 and 70 years (52 men and 109 women) who were diagnosed with hypercholesterolemia between July 2007 and February 2008 at Asan Medical Center were enrolled in this study. The patients were educated on lifestyle modifi cations by trained family physicians. We measured clinical, anthropometric, lifestyle parameters and lipid profiles initially and at eight weeks after education. Stepwise multiple linear regression models were used to assess covariates and variance components.Results: The serum level of LDL-cholesterol decreased in both women (8.0 ± 15.37%, P < 0 .001) and men (4.95 ± 9.81%, P < 0.001). In women, dietary adherence (Ղ = 0.267, P = 0.004), change in physical activity duration (Ղ = 0.196, P = 0.034) and menopausal state (Ղ = -0.207, P = 0.026) were signifi cant predictors in response of percent change in LDL- cholesterol. In men, dietary adherence (Ղ = 0.372, P = 0.007) was a predictor in response of percent change in LDL-cholesterol.Conclusion: Adherence to lifestyle modifi cation was a main factor which had infl uenced on response of percent change in LDL-C levels. In women, however, menopausal state was also an important factor.
