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Korean J Fam Med > Volume 30(5); 2009 > Article
Korean Journal of Family Medicine 2009;30(5):369-377.
DOI: https://doi.org/10.4082/kjfm.2009.30.5.369    Published online May 10, 2009.
Determinants of Responsiveness of LDL-cholesterol Lowering to Lifestyle Modification in Hypercholesterolemic Patients.
Hea Jin Lee, Young Won Seo, Kyung Eun Yun, Hye Soon Park
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hyesoon@amc.seoul.kr
고콜레스테롤혈증 환자에서 생활습관 중재 시LDL-콜레스테롤 변화와 관련된 요인
이혜진, 서용원, 윤경은, 박혜순
울산대학교 의과대학 서울아산병원 가정의학교실
Abstract
Background
Current guidelines for the treatment of hyperlipidemia propose lifestyle modification as a first-line intervention. The aim of this study was to identify the factors which determine responsiveness of LDL-cholesterol lowering to lifestyle modifi cation in hypercholesterolemic patients.Methods: A total of 109 patients aged between 30 and 70 years (52 men and 109 women) who were diagnosed with hypercholesterolemia between July 2007 and February 2008 at Asan Medical Center were enrolled in this study. The patients were educated on lifestyle modifi cations by trained family physicians. We measured clinical, anthropometric, lifestyle parameters and lipid profiles initially and at eight weeks after education. Stepwise multiple linear regression models were used to assess covariates and variance components.Results: The serum level of LDL-cholesterol decreased in both women (8.0 ± 15.37%, P < 0 .001) and men (4.95 ± 9.81%, P < 0.001). In women, dietary adherence (Ղ = 0.267, P = 0.004), change in physical activity duration (Ղ = 0.196, P = 0.034) and menopausal state (Ղ = -0.207, P = 0.026) were signifi cant predictors in response of percent change in LDL- cholesterol. In men, dietary adherence (Ղ = 0.372, P = 0.007) was a predictor in response of percent change in LDL-cholesterol.Conclusion: Adherence to lifestyle modifi cation was a main factor which had infl uenced on response of percent change in LDL-C levels. In women, however, menopausal state was also an important factor.
Key Words: Lifestyle Modifi cation; Hypercholesterolemia; LDL-cholesterol
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