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Korean J Fam Med > Volume 30(3); 2009 > Article
Korean Journal of Family Medicine 2009;30(3):190-196.
DOI: https://doi.org/10.4082/kjfm.2009.30.3.190    Published online March 20, 2009.
Association between Smoking Status and Insulin Resistance in Apparently Healthy Korean Men.
Hak Jung Kim, Jun Su Kim, Jun Hyun Yoo
1Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. drjohn.yoo@samsung.com
2Department of Family Medicine, Pusan Paik Hospital, Inje University School of Medicine, Busan, Korea.
건강한 한국 성인 남성에서 흡연 상태와 인슐린 저항성과의 연관성
김학중, 김준수, 유준현
Several studies have suggested that smoking may cause insulin resistance. However, the association between smoking and insulin resistance is still controversial. The purpose of this study was to investigate the association between smoking status and insulin resistance in Korean nondiabetic male population.Methods: A total of 5,969 men, aged > 20 years were recruited from those who visited the Health Promotion Center, Samsung Medical Center between 2005 and 2006. All subjects were divided into three categories: on-smokers (n = 2,594), ex-smokers (n = 1,580), and current-smokers (n = 1,795). Fasting values for glucose and insulin were used to estimate insulin resistance by HOMA (homeostasis model assessment). An independent association between smoking status and HOMA-IR (homeostasis model assessment of insulin resistance) was assessed after adjustment for factors infl uencing insulin sensitivity such as age, exercise, alcohol, body mass index, abdominal circumference, and blood pressure.Results: HOMA-IR was signifi cantly higher in ex-smokers and current-smokers than in non-smokers (2.09 ± 0.94 vs. 2.04 ± 0.90, 1.96 ± 0.86, P < 0.01, respectively). After adjustment for factors potentially affecting insulin sensitivity (age, alcohol intake, exercise, BMI, body fat, abdominal circumference, and blood pressure), the association persisted for ex-smokers (P = 0.008). And HOMA-IR was signifi cantly higher in ≥ 40 pack-years smokers than in non-smokersConclusion: Based on HOMA-IR, previous-smoking and chronic smoking were significantly associated with insulin resistance in apparently healthy Korean nondiabetic men.
Key Words: Cigarette Smoking; Insulin Resistance; HOMA-IR; Pack-Years


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