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Korean J Fam Med > Volume 32(2); 2011 > Article
Korean Journal of Family Medicine 2011;32(2):89-96.
DOI: https://doi.org/10.4082/kjfm.2011.32.2.89    Published online February 20, 2011.
New Insight into the Action of Vitamin D.
Hee Jeong Choi
Department of Family Medicine, Eulji University School of Medicine, Daejeon, Korea. ohinia@paran.com
비타민 D 작용에 대한 새로운 조명
을지대학교 의과대학 가정의학교실
Vitamin D deficiency is now recognized as a pandemic with more than half of the world's population currently at risk. Traditionally, vitamin D has been associated primarily with bone and calcium metabolism. However, it is now known that adequate vitamin D status is important for optimal function of many organs and tissues throughout the body. This discovery has provided new insights into the action of vitamin D. Many epidemiologic studies have demonstrated an association between vitamin D deficiency and the risk of various chronic diseases, including cardiovascular disease, diabetes, cancers, autoimmune diseases, and infectious diseases. However, it is not enough to limit definitive conclusions. Large randomized controlled trials are needed to establish the relevance of vitamin D status to such as chronic diseases. Vitamin D deficiency and insufficiency can be both treated and prevented safely through supplementation. Recommendation of adequate vitamin D intake should be considered in appropriate patients to optimize general health. In this article, I review its role in skeletal and extraskeletal health and the adverse impact of vitamin D deficiency on musculoskeletal system, cardiometabolic health, immune system, and oncogenesis, and suggest strategies for prevention and treatment of vitamin D deficiency.
Key Words: Vitamin D; Vitamin D Deficiency; Sunlight; Cholecalciferol; Supplement
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