The Role of Mean Platelet Volume as a Predicting Factor of Asymptomatic Coronary Artery Disease.

Chang, Hyun Ah; Hwang, Hwan Sik; Park, Hoon Ki; Chun, Min Young; Sung, Ja Young

doi:2010.31.8.600

Korean J Fam Med > Volume 31(8); 2010 > Article

Original Article

Korean Journal of Family Medicine 2010;31(8):600-606.
DOI: https://doi.org/10.4082/kjfm.2010.31.8.600 Published online August 20, 2010.

The Role of Mean Platelet Volume as a Predicting Factor of Asymptomatic Coronary Artery Disease.

Hyun Ah Chang, Hwan Sik Hwang, Hoon Ki Park, Min Young Chun, Ja Young Sung

¹Department of Family Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea. fmhwang@hanyang.ac.kr
²Department of Global Medical Science, Sungshin Women's University, Seoul, Korea.

증상이 없는 관상동맥 질환의 예측 인자로서 평균 혈소판 용적의 역할

장현아, 황환식, 박훈기, 전민영, 성자영

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Abstract

Background
Platelet has been known as an implicating factor in the pathophysiology of atherosclerotic disease. Larger platelets are more reactive and produce more prothrombotic factors. Several studies have shown relationship between mean platelet volume (MPV) and coronary artery disease. The present study has been designed to investigate association of MPV and subclinical CAD (coronary artery disease; abnormal finding in coronary multidetector computed tomo-graphy [MDCT] in asymptomatic individual). Methods: This cross sectional study was carried out in 103 men and 72 women (over 40 years old) who underwent coronary MDCT as screening test for disease prevention in the health examination center of Hanyang University Medical Center in Korea from January 1 to April 30, 2009. Subclinical CAD was defined when either of the following findings are present in asymptomatic patients: 1) plaque or calcification, 2) stenosis of any level. After adjustment for age, gender, hypertension, diabetes, BMI, smoking (pack-years), LDL cholesterol, odds ratios (ORs) for the prevalence of the subclinical CAD were calculated for quintiles of MPV using logistic regression analysis. Results: After adjustment for age, gender, hypertension, diabetes, BMI, smoking (pack-years), LDL cholesterol, the OR for subclinical CAD, comparing the fifth quintile of MPV with the first quintile, was 5.83 (95% confidence interval, 1.51 to 22.42; P = 0.010). Conclusion: Highest level of MPV is independently associated with the prevalence of the subclinical CAD after adjusting for other risk factors.

Key Words: Mean Platelet Volume; Coronary Artery Disease; Platelet; Atherosclerosis; Coronary Multidetector Computed Tomography