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Korean J Fam Med > Volume 30(5); 2009 > Article
Korean Journal of Family Medicine 2009;30(5):359-368.
DOI: https://doi.org/10.4082/kjfm.2009.30.5.359    Published online May 10, 2009.
Biochemical Markers and Health Behavior Related with Bone Mineral Density in Adult Men.
Eun Hae Kim, Hee Kyung Joh, Eun Young Kim, Dong Yung Cho, Hyuk Jung Kweon, Jae Kyung Choi, Youl Lee Lym, Hyun Jin Do, Seung Won Oh
Department of Family Medicine, School of Medicine, Konkuk University, Seoul, Korea. joe@kuh.ac.kr
성인 남성에서 골밀도와 관련된 생화학적 지표 및 생활습관 요인
김은해, 조희경, 김은영, 조동영, 권혁중, 최재경, 임열리, 도현진, 오승원
건국대학교 의학전문대학원 가정의학교실
More than half of the causes of male osteoporosis is due to secondary osteoporosis. Therefore, it is important to detect and modify its related factors. The aim of this study was to fi nd related lifestyle factors and biochemical markers with low bone mineral density (BMD) in Korean men.Methods: A cross-sectional analysis was performed in men aged 40-69 years who visited a hospital for health checkup from January to March 2007. BMD was measured at proximal femur and lumbar spine by dual energy x-ray absorptionmetry. Lifestyle factors were estimated by a self-administered questionnaire and fasting glucose, uric acid, gamma glutamyltransferase, alkaline phosphatase, creatinine, free testosterone, 25-OH vitamin D, urine deoxypyridinoline, osteocalcin were measured. Multivariate logistic regression was used to fi nd the association to the lowest tertile of BMD. Results: A total of 152 subjects were included. After multivariate analysis adjusted with age, BMI, smoking, alcohol and exercise, different factors were correlated with low bone density in each site of femoral neck and lumbar spine. Factors correlated at both sites were BMI and exercise; lower BMI and doing no exercise increased risks of low bone density. Increasing age and alcohol intake ≥ 14 drinks/week were associated with lower BMD at femoral neck. The factors associated with lower lumbar spine BMD only were lower level of uric acid and higher level of urine deoxypyridinoline.Conclusion: Different factors were associated with low bone density at femoral neck and lumbar spine in men. BMI and exercise were related in both sites; age, alcohol intake, uric acid and deoxypyridinoline were related on either site.
Key Words: Bone Density; Men; Smoking; Alcohol Drinking; Exercise; Biochemical Marker; Deoxypyridinoline; 25-OH Vitamin D


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