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Korean J Fam Med > Volume 30(2); 2009 > Article
Korean Journal of Family Medicine 2009;30(2):98-105.
DOI: https://doi.org/10.4082/kjfm.2009.30.2.98    Published online February 10, 2009.
Metabolic Syndrome and the Risk for Chronic Kidney Disease among Korean Women.
Sun Kyung Chae, Jee Soo Lee, Jee Hyun Chun, Hye Soon Park
Department of Family Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. hyesoon@amc.seoul.kr
성인 여자에서 대사증후군과 만성 신질환과의 관계
채선경, 이지수, 천지현, 박혜순
울산대학교 의과대학 서울아산병원 가정의학교실
Abstract
Background
Metabolic syndrome (MetS), characterized by abdominal obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, high blood pressure, and high fasting glucose level, is a common risk factor for cardiovascular disease and associated complication. We examined the relationshipbetween the metabolic syndrome and risk of chronic kidney disease (CKD) in Korean women. Methods: We used data from 10,170 women, aged 30-89 years, who had visited the health examination center at a tertiary care hospital in 2006. The data were studied cross-sectionally. MetS was identified using the modified criteria of the National Cholesterol Education Program Adult Treatment Panel Ⅲ (NCEP-ATPⅢ). CKD was defined as an estimated GFR< 60 ml/min per 1.73 m2. The multivariable-adjusted(adjustment for age, a high school education, body mass index (BMI),alcohol drinking, current and former smoking, previous coronary heart disease, menopause and physical inactivity) odds ratio of CKD (95% CI) associated with each component of the metabolic syndrome, was calculated using logistic regression models. Result: 1,039 participants developed MetS. The multivariable-adjusted odds ratios (OR) of CKD in participants with MetS, hypertriglyceridemia and high blood pressure compared with participants without those factors were 2.68 (95% CI, 1.77-4.06), 1.96 (95% CI, 1.34-2.88), 2.00(95% CI, 1.38-2.89). Compared with participants with no MetS traits, those with one, two, equal to or more than three traits of MetShad OR of CKD of 1.24 (95% CI, 0.75-2.06), 1.56 (95% CI, 0.89-2.75), 2.18 (95% CI, 1.21-3.93), respectively. Conclusion: We found that Korean women with MetS had an increased risk for developing CKD. Finally, earlier identification and management of MetS might improve patient health and prevent the progression of CKD.
Key Words: Metabolic Syndrome Chronic Kidney Disease Glomerular Filtration Rate


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