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Review Articles
Current Status of Physical Activity in South Korea
Yoo Bin Seo, Yun Hwan Oh, Yun Jun Yang, on behalf of the Korea Interest Group of Physical Activity
Korean J Fam Med 2022;43(4):209-219.   Published online July 19, 2022
DOI: https://doi.org/10.4082/kjfm.22.0099
The health benefits of physical activity have been well established. However, more than a quarter of the adult population in the world is insufficiently active (not performing at least 150 minutes of moderate-intensity physical activity per week, 75 minutes of vigorous-intensity physical activity per week, or any equivalent combination of the two), and there has been little improvement since 2001. In South Korea, the prevalence of insufficient physical activity was 54.4% in adults and 94.1% in adolescents in 2020. There was continuous decrease in the prevalence of sufficient aerobic physical activity, from 58.3% in 2014 to 45.6% in 2020. However, daily duration of sedentary behavior increased from 7.5 to 8.6 hours in the same period. Interventions to promote physical activity are necessary in various fields including clinical and policy approaches. As physical activity has decreased during the coronavirus disease 2019 pandemic, safer and more effective strategies to promote physical activity are required.

Citations

Citations to this article as recorded by  
  • Retrospective observational study of the association between changes in physical activity and frailty in middle-aged and older adults: evidence from the Korean Longitudinal Study of Aging (2006–2022)
    Ye Jun Jung, Junhyuk Kim, Yun Seo Jang, Eun-Cheol Park
    BMJ Open.2025; 15(1): e092072.     CrossRef
  • Sedentary Behavior and Its Association With Psychological Well-Being and Sleep Quality in Adolescents: Evidence from a Propensity Score Analysis
    Lirong Zhang, Shaocong Zhao, Shuangyin Zhao, Hua Zheng, Yizhen Ke, Weichen Yang, Mingxing Lei
    Psychology Research and Behavior Management.2025; Volume 18: 281.     CrossRef
  • Application of the Multi-Process Action Control model framework to predict physical activity: a study on Korean university students
    Doheung Lee, Heejung Jung, Seungjoo Lee, Sungho Kwon
    Psychology & Health.2025; : 1.     CrossRef
  • Maintaining optimal cardiovascular health metrics and carotid intima-media thickness among Korean adolescents
    Fumie Kaneko, Hokyou Lee, Jee-Seon Shim, Hyeon Chang Kim
    Clinical Hypertension.2025;[Epub]     CrossRef
  • Assessing adherence to physical activity guidelines and correlates among older Korean adults with a focus on 10-minute bout duration using subjective and objective measures
    Junhui Park, Su Hyun Kim, Young Hoon Kim, Chang-Hyung Lee, Timoteo Salvador Lucas Daca
    PLOS One.2025; 20(6): e0324342.     CrossRef
  • Trends in obesity, leisure-time physical activity, and sedentary behavior in Korean adults: Korea national health and nutritional examinations survey from 2014 to 2021
    Yunmin Han, Hoyong Sung, Younghwan Choi, Yeon Soo Kim, Hee-Taik Kang
    PLOS ONE.2024; 19(1): e0296042.     CrossRef
  • Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study
    Seung Yeon Cho, Jiwon Jeong, Sangah Shin
    Alcohol.2024; 121: 133.     CrossRef
  • Feasibility of Mobile Health App-Based Home Aerobic Exercise for Physical Performance in Healthy Young Adults
    Je Shik Nam, Hyun-Ah Kim, Tae-Jin Kwak, Kang Hee Cho, Il-Young Jung, Chang-Won Moon
    Annals of Rehabilitation Medicine.2024; 48(1): 75.     CrossRef
  • Racial Differences in Ischemic and Hemorrhagic Stroke: An Ecological Epidemiological Study
    Dong-Seon Kang, Pil-Sung Yang, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
    Thrombosis and Haemostasis.2024; 124(09): 883.     CrossRef
  • Guidelines for physical activity counseling in primary healthcare clinics
    Yun Jun Yang
    Journal of the Korean Medical Association.2024; 67(4): 265.     CrossRef
  • Exploring the meanings and aspects of urban walking in Seoul for active living
    Eunbyeol Cho, Chaerim Lee, Dong Ha Kim, Seunghyun Yoo
    Korean Journal of Health Education and Promotion.2024; 41(1): 89.     CrossRef
  • Effects of public transportation use on non-exercise activity thermogenesis and health promotion: a mini-review
    Sung-Woo Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Taeho Kim, Jongwon Kim, Inseop Shin, Kiwon Lim
    Physical Activity and Nutrition.2024; 28(1): 031.     CrossRef
  • Physical Inactivity and Sedentariness in Older Hearing Loss patients: Restoration With Hearing Aids
    Sang‐Yoon Han, Hee Won Seo, Seung Hwan Lee, Jae Ho Chung
    The Laryngoscope.2024; 134(12): 5109.     CrossRef
  • Impacts of smoking on alcoholic liver disease: a nationwide cohort study
    Jeong-Ju Yoo, Dong Hyeon Lee, Sang Gyune Kim, Jae Young Jang, Young Seok Kim, Log Young Kim
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Effectiveness of an e-Book on Bone Health as Educational Material for Adolescents: Single-Group Experimental Study
    Nor Aini Jamil, Jashwiny Dhanaseelan, Nurin Athirah Buhari
    JMIR Pediatrics and Parenting.2024; 7: e56611.     CrossRef
  • The impact of fear of falling on health-related quality of life in community-dwelling older adults: mediating effects of depression and moderated mediation effects of physical activity
    Eun Sook Lee, Boyoung Kim
    BMC Public Health.2024;[Epub]     CrossRef
  • Handgrip strength thresholds associated with metabolic syndrome risk in children and adolescents: a systematic review and meta-analysis
    Hye Ah Lee, Seunghee Jun, Hyesook Park
    Epidemiology and Health.2024; 46: e2024047.     CrossRef
  • Increased Intake of Omega-3 Polyunsaturated Fatty Acids Is Associated with Reduced Odds of Low Hand Grip Strength in Korean Adults
    Yoonjin Shin, Eugene Chang
    Nutrients.2023; 15(2): 321.     CrossRef
  • A Cross-Sectional Investigation of the Association between Arterial Stiffness and Depressive Symptoms, Anxiety Symptoms, and Quality of Life
    Tae-Kyung Yoo, Seunghee Lee, Soo-Young Hwang, Curie Ahn, Saejong Park, Jong-Young Lee
    Medicina.2023; 59(3): 477.     CrossRef
  • Combinations of lifestyle behaviors and cancer risk among Korean adults
    Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
    Scientific Reports.2023;[Epub]     CrossRef
  • Does Excessive Smartphone Use Reduce Physical Activity in Adolescents?
    Soo Young Kim
    Korean Journal of Family Medicine.2023; 44(5): 247.     CrossRef
  • Discordance in Secular Trends of Bone Mineral Density Measurements in Different Ages of Postmenopausal Women
    Kwang Yoon Kim, Jaesun Park, Sungwon Yang, Junghwa Shin, Ji Hyun Park, Bumhee Park, Bom Taeck Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • The role of collegiate sport experience in social adjustment and quality of college life: moderating role of the school year
    Weisheng Chiu, Heetae Cho, Seungmo Kim
    Asia Pacific Journal of Education.2023; : 1.     CrossRef
  • Physical activity trajectories of different grade levels of male adolescents in association of academic performance and mental health
    Haemi Jee
    Journal of Exercise Rehabilitation.2023; 19(5): 258.     CrossRef
  • Age and sex differences in coronal lower extremity alignment in a healthy Asian population
    Doohyun Hwang, Min Wook Choi, Seong-Hwan Kim, Hyuk-Soo Han, Chong Bum Chang, Myung Chul Lee, Na-Kyoung Lee, Du Hyun Ro
    The Knee.2023; 45: 198.     CrossRef
  • Trends in the effects of socioeconomic position on physical activity levels and sedentary behavior among Korean adolescents
    Hunju Lee, Hyowon Choi, Sang Baek Koh, Hyeon Chang Kim
    Epidemiology and Health.2023; 45: e2023085.     CrossRef
  • The Difference in the Prevalence of Metabolic Syndrome According to Meeting Guidelines for Aerobic Physical Activity and Muscle-Strengthening Exercise: A Cross-Sectional Study Performed Using the Korea National Health and Nutrition Examination Survey, 201
    Du Ho Kwon, Young Gyu Cho, Hyun Ah Park, Ho Seok Koo
    Nutrients.2022; 14(24): 5391.     CrossRef
  • Current status of physical activity in Korea and exercise prescriptions
    Yun Jun Yang
    Journal of the Korean Medical Association.2022; 65(12): 810.     CrossRef
  • 8,608 View
  • 176 Download
  • 27 Web of Science
  • 28 Crossref
Current Status of the National Health Screening Programs in South Korea
Hee-Taik Kang
Korean J Fam Med 2022;43(3):168-173.   Published online May 20, 2022
DOI: https://doi.org/10.4082/kjfm.22.0052
A health check-up is one of the best ways to prevent diseases and maintain health by screening for risk factors and diagnosing diseases early. As the burden of illness shifts from infectious to chronic diseases, the importance of health check-ups is emphasized. Korean health authorities began the National Health Screening Programs (NHSPs) for public servants and private school staff in 1980. The NHSP is composed of the National Cancer Screening Programs (NCSPs) and general health checkups. NCSPs, started in 1999, included screenings for stomach, liver, colorectal, breast, and uterine cervical cancers, and they may have contributed to the improved cancer survival rate from 42.9% in 1993–1995 to 77.5% in 2013–2017 in Korea. General health check-ups included lifestyle questionnaires, anthropometric measurements; blood pressure measurement; visual acuity test; hearing test; laboratory tests including fasting glucose, lipid profile, liver function tests, creatinine, and urinalysis; and, chest radiography. Additionally, bone density, cognitive function, and depression were assessed. Testing for non-communicable diseases has improved the control rates of chronic diseases such as hypertension and diabetes mellitus. Favorable changes in the risk factors for cardio-cerebrovascular diseases may lead to a decline in age-standardized mortality and heart disease over several decades. However, many areas of the programs need to be improved. NHSPs should be designed on the basis of individual health conditions, medical needs, and scientific evidence. Greater opportunities to receive NHSPs should be provided to socioeconomically vulnerable individuals. In addition, stricter quality control of NHSPs is required. Follow-up management after the NHSPs should be systematized. In conclusion, NHSPs have contributed to the improvement of public health; however, several aspects of these programs must be addressed.

Citations

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  • Impact of mild traumatic brain injury on health behaviors
    Yookyung Lee, Yoonjeong Choi, Jooeun Jeon, Ja-Ho Leigh, Don-Kyu Kim, Byung-Mo Oh
    Scientific Reports.2025;[Epub]     CrossRef
  • Nonalcoholic Fatty Liver Disease Increases the Risk of Lung Abscess: Findings from a Nationwide Cohort Study
    Eunso Lee, Jungok Kim, Sun-Young Yoon
    Journal of Clinical Medicine.2025; 14(2): 542.     CrossRef
  • Utilization of preventative health checkup services in China among middle-aged and older adult population: evidence from China’s 28 provinces
    Jingyu Shen, Weiji Fang, Yating Zhu, Chunli Ye, Yanhua Zhu, Yanling Tao
    Frontiers in Public Health.2025;[Epub]     CrossRef
  • Indonesia's first nationwide health screening programme
    Aqsha Nur, Dante Harbuwono
    The Lancet Global Health.2025; 13(4): e620.     CrossRef
  • Association of Precarious Employment With Unmet Healthcare Needs and Health Checkup Participation
    Seong-Uk Baek, Jin-Ha Yoon
    American Journal of Preventive Medicine.2025; 68(6): 1120.     CrossRef
  • Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study
    Chang-Uk Jeong, Jacob S Leiby, Dokyoon Kim, Eun Kyung Choe
    JMIR Aging.2025; 8: e64473.     CrossRef
  • Diabetes status, duration, and risk of dementia among ischemic stroke patients
    Jonguk Kim, Kyung-Do Han, Jeong-Yoon Lee, Ye Seul Yang, Dae Young Cheon, Jae-Jun Lee, Minwoo Lee
    Alzheimer's Research & Therapy.2025;[Epub]     CrossRef
  • Association Between Suicidal Ideation and Cancer Screening Uptake: Results from Middle-Aged and Older Adults in Korea
    Seong-Uk Baek, Jin-Ha Yoon
    Cancers.2025; 17(6): 956.     CrossRef
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    Binish Islam, Tasiu Ibrahim Ibrahim, Wang Tingting, Mingyang Wu, Qin Jiabi
    Journal of Global Health.2025;[Epub]     CrossRef
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    BMC Public Health.2025;[Epub]     CrossRef
  • Trajectories of Health Screening Uptake: Focusing on Perceived Barriers Among Middle-Aged and Older Adults in Korea
    Sunha Choi
    Journal of Gerontological Social Work.2025; : 1.     CrossRef
  • Unmet Needs Mediate the Impact of Fear of Cancer Recurrence on Screening Participation Among Cancer Survivors: A Cross-Sectional Study
    Mi-Lee Kim, Yeol Kim, Yu-Ri Choe
    Healthcare.2025; 13(10): 1184.     CrossRef
  • Regularity of cervical cancer screening in Korea: analysis using national public data for 12 years
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    Journal of Gynecologic Oncology.2024;[Epub]     CrossRef
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    Marie Yan, Brooke Fraser, Eric McArthur, Matty Mehrabi, Sarah K. Brode, Theodore K. Marras
    CHEST.2024; 165(3): 521.     CrossRef
  • Association between long working hours and engagement in preventive healthcare services in Korean workers: Findings from the Korean National Health and Nutrition Examination Survey
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    Preventive Medicine.2024; 180: 107849.     CrossRef
  • Extrahepatic Malignancies Are the Leading Cause of Death in Patients with Chronic Hepatitis B without Cirrhosis: A Large Population-Based Cohort Study
    Young Eun Chon, Sung Jun Park, Man Young Park, Yeonjung Ha, Joo Ho Lee, Kwan Sik Lee, Eileen L. Yoon, Dae Won Jun
    Cancers.2024; 16(4): 711.     CrossRef
  • Risk of Cardiovascular Disease according to Baseline Low-Density Lipoprotein Cholesterol Level in Different Age Groups in Korean Diabetes Population: A Cohort Study
    Tae Kyung Yoo, Kyung-Do Han, Eun-Jung Rhee, Won-Young Lee
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  • Temporal Trend in Uptake of the National General Health Checkups and Cancer Screening Program among Korean Women with Breast Cancer
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    BMC Public Health.2023;[Epub]     CrossRef
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    Diagnostics.2022; 12(8): 1967.     CrossRef
  • 7,230 View
  • 156 Download
  • 34 Web of Science
  • 40 Crossref
Preventive Measures against the Development of Dementia in Old Age
Israel Oluwasegun Ayenigbara
Korean J Fam Med 2022;43(3):157-167.   Published online May 20, 2022
DOI: https://doi.org/10.4082/kjfm.21.0030
Dementia is a neurological condition characterized by numerous types of central nervous system diseases, which gradually deteriorates an individual’s reasoning, rational thinking, and judgment abilities. As a serious public health concern that currently affects more than 50 million older adults, dementia is one of the most significant causes of incapacity, disability, and dependency among older adults. As new cases are expected to increase exponentially in the next three decades, dementia, which is not a normal feature of healthy aging despite the fact that it generally affects older adults disproportionately, requires enormous management and care efforts due to its associated socioeconomic, psychological, and physical burdens that involve the patient, their caregivers, guardians, family members, and society at large. Presently, there is no cure for dementia; however, this condition could be prevented. This narrative review aimed to provide a broad overview of studies detailing the alternative lifestyle modification-centered preventive measures against dementia. A comprehensive search of key databases to find articles related to this topic revealed that participating in regular physical activities, healthy eating and dieting, avoiding all forms of smoking, avoiding air pollutants, halting or reducing alcohol consumption, exercising the mind and being socially dynamic, getting enough rest and establishing good sleeping habits, infection prevention, stress prevention, avoidance of injuries, preventing the effects of social isolation and lockdowns, continuing education, and depression prevention are protective measures against the development of dementia.

Citations

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  • Guidelines for nutrition counseling in primary healthcare clinics
    Gyeongsil Lee, Seung-Won Oh
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    Xiaowen Cao, Yao Dong, Li Xing, Xuekui Zhang
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    Sung Sunwoo
    Journal of the Korean Medical Association.2022; 65(12): 772.     CrossRef
  • 6,435 View
  • 129 Download
  • 2 Web of Science
  • 3 Crossref
Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates
Rania Itani, Lama Soubra, Samar Karout, Deema Rahme, Lina Karout, Hani M J Khojah
Korean J Fam Med 2022;43(2):101-108.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.21.0103
Primary dysmenorrhea (PD) is a common, disregarded, underdiagnosed, and inadequately treated complaint of both young and adult females. It is characterized by painful cramps in the lower abdomen, which start shortly before or at the onset of menses and which could last for 3 days. In particular, PD negatively impacts the quality of life (QOL) of young females and is the main reason behind their absenteeism from school or work. It is suggested that increased intrauterine secretion of prostaglandins F2α and E2 are responsible for the pelvic pain associated with this disorder. Its associated symptoms are physical and/or psychological. Its physical symptoms include headache, lethargy, sleep disturbances, tender breasts, various body pains, disturbed appetite, nausea, vomiting, constipation or diarrhea, and increased urination, whereas its psychological symptoms include mood disturbances, such as anxiety, depression, and irritability. While its diagnosis is based on patients’ history, symptoms, and physical examination, its treatment aims to improve the QOL through the administration of nonsteroidal anti-inflammatory drugs, hormonal contraceptives, and/or the use of non-pharmacological aids (e.g., topical heat application and exercise). Patients must be monitored to measure their response to treatment, assess their adherence, observe potential side effects, and perform further investigations, if needed.

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    Aslı Karakuş Selçuk, Ebru Baysal
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    Ida Ayu Suptika Strisanti, Ida Ayu Anom Rastiti, Ni Wayan Kesari Dharmapatni
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    Akbar Anaeigoudari
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    Samar Karout, Lama Soubra, Deema Rahme, Lina Karout, Hani M J Khojah, Rania Itani
    BMC Women's Health.2021;[Epub]     CrossRef
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  • 755 Download
  • 97 Web of Science
  • 112 Crossref
Teaching Family Medicine and General Practice
Muhammad Jawad Hashim
Korean J Fam Med 2022;43(2):93-100.   Published online March 17, 2022
DOI: https://doi.org/10.4082/kjfm.20.0223
The teaching of family medicine and general practice should aim to develop an appreciation of the unique nature and role of the specialty. Teachers should relate patient cases to the principles of family medicine. These principles include (1) compassionate care; (2) a generalist/holistic approach focusing on the whole person, family, and community; (3) continuity of relationship, i.e., building a patient-physician bond of trust; (4) reflective mindfulness; and (5) lifelong learning. The curriculum, instructional strategy, and assessment should be carefully aligned. Core competencies include patient-centered communication, physical examination skills, clinical procedures, palliative care, humanities in medicine, holistic care, shared decision-making, family therapy, home and community visits, chronic disease care, problem-based documentation, team-based care, data-driven improvement, information mastery, ethics and professionalism, and work-life balance. Family medicine/general practice is defined as the medical specialty that manages common and long-term illnesses, focusing on overall health and well-being. Hence, clerkship schedules should maximize clinical exposure and opportunities for self-reflection. A learner-centered approach should begin with a self-identified inventory of learning needs based on the curriculum; next, these needs should be chosen as topics for student presentations. Teaching methods should include mini-workshops: a combination of didactic lectures and small-group exercises. Individual face-to-face formative feedback should occur at midcourse and culminate in a group reflection on the learning experience. Clinical supervision should gradually decrease as each resident demonstrates safe patient care. Procedure skills training should be closely supervised, formally documented, and constitute about one-fourth of learning sessions.

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  • Use of audio-visual aids and case studies to enhance understanding of family medicine among medical students
    Stephen T. Engmann
    African Journal of Primary Health Care & Family Medicine.2024;[Epub]     CrossRef
  • Guidelines for nutrition counseling in primary healthcare clinics
    Gyeongsil Lee, Seung-Won Oh
    Journal of the Korean Medical Association.2024; 67(4): 278.     CrossRef
  • Disease prevention measures applicable to primary healthcare clinics
    Jae-Heon Kang
    Journal of the Korean Medical Association.2024; 67(4): 226.     CrossRef
  • Perception of Family Medicine Residents on the Use of Small Group Discussion in Comparison to Standard Lectures
    Ahmed Mohammed Gharawi, Abdullah Mohammed Alateeq, Ghada Alarfaj, Ayman Afify, Saad Albatal, Alaa Alahmari, Mostafa Kofi
    European Journal of Contemporary Education and E-Learning.2024; 2(5): 3.     CrossRef
  • Strengthening Primary Health Care through Medical Education
    Seung-Won Oh
    Korean Journal of Family Medicine.2023; 44(4): 181.     CrossRef
  • 5,591 View
  • 144 Download
  • 4 Web of Science
  • 5 Crossref
Complexity of the Diagnosis of COVID-19 in the Context of Pandemicity: Need for Excellence in Diagnostic Acumen
Suresh K. Joishy, Michito Sadohara, Masaru Kurihara, Yasuharu Tokuda
Korean J Fam Med 2022;43(1):16-26.   Published online January 20, 2022
DOI: https://doi.org/10.4082/kjfm.20.0188
Coronavirus disease 2019 (COVID-19) is a highly infectious disease that has caused a pandemic devastating many countries worldwide. It is a complex and multifaceted disease with a unique coronavirus etiology, pathogenesis, zoonotic, and human-to-human transmission, causing acute respiratory distress syndrome with high mortality. Accurate and timely diagnosis is of utmost importance. In this study, we discussed the complexities of COVID-19 diagnostic elements in the context of pandemicity, drawing from our awareness, observations, and lessons learned from two previous coronavirus pandemics, namely SARS-CoV (severe acute respiratory syndrome coronavirus) in 2002 and MERS-CoV (Middle East respiratory syndrome-related coronavirus) in 2012, and how they applied to the diagnosis of COVID-19 today. Diagnosis of COVID-19 takes place without physician-patient personal contact due to isolation or quarantine or in the hospital setting, emergency units, and critical care units with the cumbersome barriers of personal protective equipment. Technical diagnosis is important, but we also emphasized the human impact of diagnosing COVID-19. Conveying the diagnosis of a critical disease to patients and families requires aspects of excellence in professionalism: ethics, empathy, and humility. Diagnostic skills in COVID-19 should extend to prognostication for patients suffering at the end of life, so that they will not be deprived of high-quality palliative care and comfort.

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  • Experience of caring for patients with COVID-19 and educational achievement among Japanese resident physicians: a nationwide survey with general medicine in-training examination
    Sho Nishiguchi, Yuji Nishizaki, Miki Hamaguchi, Atshushi Goto, Masahiko Inamori, Kiyoshi Shikino, Tomohiro Shinozaki, Koshi Kataoka, Taro Shimizu, Yu Yamamoto, Sho Fukui, Hiroyuki Kobayashi, Yasuharu Tokuda
    BMC Medical Education.2024;[Epub]     CrossRef
  • 5,772 View
  • 74 Download
  • 1 Web of Science
  • 1 Crossref
Can Nutritional Supports Beneficial in Other Viral Diseases Be Favorable for COVID-19?
Fatmanur Zehra Zelka, Rümeysa Rabia Kocatürk, Öznur Özge Özcan, Mesut Karahan
Korean J Fam Med 2022;43(1):3-15.   Published online January 20, 2022
DOI: https://doi.org/10.4082/kjfm.20.0134
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), has rapidly spread worldwide, causing many deaths, the number of which continues to increase. Global public health organizations and governments have advised on the adoption of various handwashing and hygiene guidelines, use of masks, and social distancing, along with isolation or lockdown protocols to prevent SARS-COV-2 spread. There are vaccines and drugs that are confirmed but still many human suffer from this disease. Important risk factors for SARS-COV-2 infection are similar to other viral infectious diseases as including influenza, hepatitis B, acquired immunodeficiency syndrome, and other lung infections. These diseases might be related to poor nutritional support, affecting the patient outcomes against COVID-19. In this review, we discuss some of the nutritional therapies currently being investigated for infectious diseases. Studies have shown that nutrition has the potential to prevent and mitigate viral infections. Micronutrients (vitamins A, B6, B12, C, D, and E, B9, and trace elements, such as iron, zinc, copper, selenium, magnesium, and polyphenols) and macronutrients (carbohydrates, prebiotics, probiotics, protein [amino acids], and lipids [fatty acids]) affect the whole body, including the immune system, preventing viral entry and modulating clinical symptoms. This review discusses the importance of nutrition as a strategy to understand food groups and key nutrients that may affect the clinical outcomes of COVID-19 patients during the ongoing pandemic. Scientists believe that the likelihood of another pandemic is imminent. COVID-19 remains important and scientists believe it will continue will in the future. We emphasize the lack of studies on the nutritional impact of COVID-19 in terms of nutrition, even though nutritional interventions has been shown to have many advantages during the treatment of viral infections.

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  • Guidelines for nutrition counseling in primary healthcare clinics
    Gyeongsil Lee, Seung-Won Oh
    Journal of the Korean Medical Association.2024; 67(4): 278.     CrossRef
  • Vitamin-mineral complexes to help adult patients frequently suffering with acute respiratory viral infections: A review
    Dmitry I. Trukhan, Natalya V. Bagisheva
    Consilium Medicum.2024; 26(03): 164.     CrossRef
  • Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis
    Binshan Jiang, Qiangru Huang, Mengmeng Jia, Xinai Xue, Qing Wang, Weizhong Yang, Luzhao Feng
    Chinese Medical Journal.2022;[Epub]     CrossRef
  • 6,438 View
  • 129 Download
  • 2 Web of Science
  • 3 Crossref
Malaysia Healthcare Early Response in Combatting COVID-19 Pandemic in 2020
Safiya Amaran, Ahmad Zulfahmi Mohd Kamaruzaman, Nurul Yaqeen Mohd Esa, Zaharah Sulaiman
Korean J Fam Med 2021;42(6):425-437.   Published online November 20, 2021
DOI: https://doi.org/10.4082/kjfm.20.0117
The year 2020 saw the emergence of a novel coronavirus—the severe acute respiratory syndrome coronavirus 2— which has led to an unprecedented pandemic that has shaken the entire world. The pandemic has been a new experience for Malaysia, especially during the implementation of large-scale public health and social measures called the Movement Control Order (MCO). This paper seeks to describe the experiences of the Malaysian healthcare system thus far in combatting the pandemic. The Malaysian healthcare system comprises two main arms: public health and medicine. The public health arm focuses on early disease detection, contact tracing, quarantines, the MCO, and risk stratification strategies in the community. The medical arm focuses on the clinical management of coronavirus disease 2019 (COVID-19) patients; it encompasses laboratory services, the devising of clinical setting adjustments, and hospital management for COVID-19 and non-COVID-19 patients. Malaysia experienced intense emotions at the beginning of the pandemic, with great uncertainty regarding the pandemic’s outcome, as the world saw a frighteningly high COVID-19 mortality. As of writing (May 30, 2020), Malaysia has passed the peak of its second wave of infections. The experience thus far has helped in preparing the country’s healthcare system to be vigilant and more prepared for future COVID-19 waves. To date, the pandemic has changed many aspects of Malaysia’s life, and people are still learning to adapt to new norms in their lives.

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  • Unveiling the Nexus Between Intellectual Capital Efficiency and Financial Performance in Malaysia's Healthcare Sector Amidst the Covid-19 Crisis
    Noor Sharida Badri Shah, Roslan Ja’afar
    Information Management and Business Review.2024; 16(1(I)): 262.     CrossRef
  • An Online Survey of the Perceptions of Clinical and Non-Clinical Professionals on Healthcare for Non-Communicable Diseases and COVID-19 Measures During the Pandemic in Malaysia
    Sugitha Sureshkumar, Feisul Mustapha, Haironi Yusoff, Kibachio Joseph Mwangi, Kailing Marcus, Bogomil Kohlbrenner, David Issom, Mohamed-Rida Benissa, Sigiriya Aebischer-Perone, Nirit Braha, Egidio Candela, Kumar Gaurav Chhabra, B. R. Desikachari, Arianna
    International Journal of Public Health.2023;[Epub]     CrossRef
  • 8,159 View
  • 143 Download
  • 2 Web of Science
  • 2 Crossref
Psoriasis and Cardiovascular Disease: A Narrative Review
Adrian Martinez-Moreno, Jorge Ocampo-Candiani, Veronica Garza-Rodriguez
Korean J Fam Med 2021;42(5):345-355.   Published online June 9, 2020
DOI: https://doi.org/10.4082/kjfm.20.0053
Psoriasis is a chronic, autoimmune, and inflammatory disease that affects 2% of the world’s population. In recent years, it has been demonstrated that psoriasis confers a 25% increase in relative risk of cardiovascular disease, independent of factors such as hyperlipidemia, smoking, and obesity. The objective of this review was to analyze and describe the association between psoriasis and cardiovascular disease. In this review, we describe the epidemiological association of psoriasis and cardiovascular disease, pathophysiology, mechanisms, and its association with the well-known cardiovascular risk calculators. In addition, we describe diagnostic tools, such as imaging techniques and novel biomarkers, that are useful in the evaluation of atherosclerotic cardiovascular disease. Finally, we present different systemic therapies that are used in patients with psoriasis and their effect on atherosclerotic cardiovascular disease. This article provides an overview of the current literature on psoriasis and cardiovascular risk, which can be useful for primary care physicians in their daily clinical practice.

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  • Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence
    Rachel Sally, Camille Robinson, Seth J. Orlow, Jerry Shapiro, Michael Garshick, Kristen Lo Sicco
    JEADV Clinical Practice.2024; 3(1): 7.     CrossRef
  • Automated mass screening and association rules analysis for comorbidities of psoriasis: A population‐based case–control study
    Bo Ri Kim, Kun Hee Lee, Kyungho Paik, Minjae Kim, Jung Min Bae, Chong Won Choi, Sang Woong Youn
    The Journal of Dermatology.2024; 51(4): 539.     CrossRef
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    Minghui Hu, Yangyang Wang, Wenwu Xu, Juan Bai, Xingming Tang
    Frontiers in Genetics.2024;[Epub]     CrossRef
  • SCORE2 Screening Tool for Cardiovascular Risk Assessment in Psoriasis—A Case–Control Study
    Tomáš Kampe, Janette Baloghová, Peter Kolarčik, Kvetoslava Rimárová, Erik Dorko
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  • Bilateral STA-MCA bypass for Moyamoya angiopathy associated with severe erythrodermic psoriasis
    Rohan Jha, Ari D. Kappel, Abdullah H. Feroze, Walid Ibn Essayed, Nirav J. Patel
    Journal of Stroke and Cerebrovascular Diseases.2024; 33(11): 107997.     CrossRef
  • Jordanian Population’s Perception and Understanding of Psoriasis: A Cross-Sectional Study
    Rand Murshidi, Nour Shewaikani, Assem Al Refaei, Dana Q Khateeb, Raghad Al-Shami, Bayan E Hwidi, Maram Nasrallah, Leen Alshamasneh, Raghad Murshidi, Mahmoud Abdallat
    Cureus.2024;[Epub]     CrossRef
  • The Impact of Treatment with IL-17/IL-23 Inhibitors on Subclinical Atherosclerosis in Patients with Plaque Psoriasis and/or Psoriatic Arthritis: A Systematic Review
    Aikaterini Tsiogka, Stamatios Gregoriou, Alexander Stratigos, Stergios Soulaidopoulos, Natalia Rompoti, Pantelis Panagakis, Marina Papoutsaki, Panagiotis Kostakis, George Kontochristopoulos, Konstantinos Tsioufis, Anna Campanati, Annamaria Offidani, Chara
    Biomedicines.2023; 11(2): 318.     CrossRef
  • Association between cardio‐cerebrovascular disease and systemic antipsoriatic therapy in psoriasis patients using population‐based data: A nested case–control study
    Bo Ri Kim, Kun Hee Lee, Jinseob Kim, Jee Woo Kim, Kyungho Paik, Woojae Myung, Hyewon Lee, Chong Won Choi, Sang Woong Youn
    The Journal of Dermatology.2023; 50(11): 1442.     CrossRef
  • Effect of psoriasis on cardiovascular risk
    Olga A. Kuzmina, Olga Iu. Mironova, Anfisa A. Lepekhova, Karinat S. Tregub, Artem I. Demin, Victor V. Fomin, Olga Yu. Olisova
    Russian Journal of Skin and Venereal Diseases.2023; 26(5): 465.     CrossRef
  • Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data
    Anna Baran, Paulina Kiluk, Julia Nowowiejska, Tomasz W. Kaminski, Magdalena Maciaszek, Iwona Flisiak
    Biology.2022; 11(1): 88.     CrossRef
  • Looking beyond the Skin: Pathophysiology of Cardiovascular Comorbidity in Psoriasis and the Protective Role of Biologics
    Isabel Andújar, Juan V. Esplugues, Patricia García-Martínez
    Pharmaceuticals.2022; 15(9): 1101.     CrossRef
  • L-Theanine Alleviates IMQ-Induced Psoriasis Like Skin Inflammation by Downregulating the Production of IL-23 and Chemokines
    Yaohan Xu, Jiang Zhu, Jingyi Hu, Ziqi Zou, Yueling Zhao, Lihua Lai, Ping Xu, Yinjing Song, Hao Cheng
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets
    Yong Liu, Shengnan Cui, Jiayi Sun, Xiaoning Yan, Dongran Han
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • Cardiovascular comorbidities in psoriasis (Review)
    Daciana Branisteanu, Alin Nicolescu, Daniel Branisteanu, Catalina Branisteanu, Andreea Dragoi, Camelia Bogdanici, Mihaela Toader, Andreea Tucaliuc, Andreea Dimitriu, Doru Daogaru, Ruxandra Pirvulescu, Elena Porumb
    Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef
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  • 233 Download
  • 14 Web of Science
  • 14 Crossref
Increasing Individual Target Glucose Levels to Prevent Hypoglycemia in Patients with Diabetes
Juyoung Shin, Hyunah Kim, Hun-Sung Kim, Churlmin Kim, Whan-Seok Choi
Korean J Fam Med 2021;42(4):269-273.   Published online January 29, 2020
DOI: https://doi.org/10.4082/kjfm.19.0161
Hypoglycemia is one of the severe complications of diabetes. To prevent hypoglycemia, an emphasis is placed on maintaining an appropriate balance between nutrition, activity, and treatment, which can be achieved by the repetition of self-trials based on self-monitoring. Clinicians routinely focus on patients’ contribution, including timely intake of an adequate amount of carbohydrates, physical activity, antidiabetic medication, and abstinence from alcohol. Recently, many guidelines have highlighted the importance of clinicians’ factors and recommend individualized treatments according to lifestyle patterns and specific needs following the de-intensification of treatment. The optimal value of hemoglobin A1c (HbA1c) levels for blood glucose level regulation remains controversial among countries, but it generally does not exceed 8.0%. In populations that are at a risk of hypoglycemia, such as the older adults, it is advisable to adjust the target blood glucose level to less than 8.0%. Meanwhile, a blood glucose level of 7.0%–7.5% is generally recommended for healthy older adults. If the expected lifetime is shorter than 10 years or in patients with chronic kidney disease and severe cardiovascular disease, the HbA1c level target can be increased to 7.5%–8.0%. For even shorter lifetime expectancy, the target can be adjusted up to 8.0%–9.0%. To prevent hypoglycemia, the target blood glucose level needs to be adjusted, particularly in older adult patients. Ultimately, it is important to identify the maximum blood glucose levels that do not cause hypoglycemia and the minimum blood glucose levels that do not cause hyperglycemia-associated complications.

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    Michelle Cohen, Kristen de Grandpre, William M. Herlihy, Lise Cooper
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    British Journal of Health Psychology.2024; 29(1): 254.     CrossRef
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    Yanzhen Jing, Shwu Jen Chang, Ching-Jung Chen, Jen-Tsai Liu
    Journal of The Electrochemical Society.2022; 169(5): 057514.     CrossRef
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  • 147 Download
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Overview of Physical Activity Counseling in Primary Care
Apichai Wattanapisit, Sanhapan Wattanapisit, Sunton Wongsiri
Korean J Fam Med 2021;42(4):260-268.   Published online May 20, 2020
DOI: https://doi.org/10.4082/kjfm.19.0113
Physical inactivity is a global health burden. Promoting physical activity in primary care through physical activity counseling is an effective intervention. This article provides an overview of and perspectives on physical activity counseling in primary care. The identification of physical inactivity as a health problem may increase the awareness of physical inactivity among patients and primary care providers, which will lead to an action plan. The contents of physical activity counseling should be based on evidence-based recommendations. Safety issues should be evaluated appropriately to optimize the utilization of primary care services. Physical activity counseling methods should be “tailored” for an individual using appropriate counseling methods and setting-specific resources. Multilevel barriers to physical activity counseling in primary care (i.e., healthcare providers, patients, and systems) must be addressed. Setting-specific strategies to overcome these barriers should be implemented to maximize the effectiveness of physical activity counseling in primary care.

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    Jacob I. McPherson, Jeffrey C. Miecznikowski, Haley Chizuk, Patrick Sparks, John J. Leddy, Mohammad N. Haider, Christopher J. Stavisky, Johanna Pruller
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    Callum Leese, Robert H Mann, Emma J Cockcroft, Kirstin Abraham
    BJGP Open.2024; 8(1): BJGPO.2023.0051.     CrossRef
  • Physical Activity with Sports Scientist (PASS) programme to promote physical activity among patients with non-communicable diseases: a pragmatic randomised controlled trial protocol
    Apichai Wattanapisit, Poramet Hemarachatanon, Kamlai Somrak, Saranrat Manunyanon, Sanhapan Wattanapisit, Areekul Amornsriwatanakul, Piyawat Katewongsa, Sorawat Sangkaew, Polathep Vichitkunakorn, Ping Yein Lee, Siti Nurkamilla Ramdzan, Hani Salim, Chirk Je
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    Yun Jun Yang
    Journal of the Korean Medical Association.2024; 67(4): 265.     CrossRef
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    Callum J. Leese, Robert H. Mann, Hussain Al-Zubaidi, Emma J. Cockcroft
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    Christine Joisten
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    Callum Leese, Kirstin Abraham, Blair H Smith
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    Tamara L. Morgan, Emma Faught, Amanda Ross-White, Michelle S. Fortier, Mary Duggan, Rahul Jain, Kirstin N. Lane, Amanda Lorbergs, Kaleigh Maclaren, Taylor McFadden, Jennifer R. Tomasone
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    Soo Young Kim
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    Yoo Bin Seo, Yun Hwan Oh, Yun Jun Yang
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    Ariana Bytyci Katanolli, Nicole Probst-Hensch, Katrina Ann Obas, Jana Gerold, Manfred Zahorka, Naim Jerliu, Qamile Ramadani, Nicu Fota, Sonja Merten
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    Heliyon.2022; 8(10): e11259.     CrossRef
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    Soo Young Kim
    Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef
  • Primary Health Care Providers’ Perspectives on Developing an eHealth Tool for Physical Activity Counselling: A Qualitative Study
    Apichai Wattanapisit, Sanhapan Wattanapisit, Titiporn Tuangratananon, Waluka Amaek, Sunton Wongsiri, Prachyapan Petchuay
    Journal of Multidisciplinary Healthcare.2021; Volume 14: 321.     CrossRef
  • Challenges of Implementing an mHealth Application for Personalized Physical Activity Counselling in Primary Health Care: A Qualitative Study
    Apichai Wattanapisit, Waluka Amaek, Sanhapan Wattanapisit, Titiporn Tuangratananon, Sunton Wongsiri, Prasert Pengkaew
    International Journal of General Medicine.2021; Volume 14: 3821.     CrossRef
  • What Elements of Sport and Exercise Science Should Primary Care Physicians Learn? An Interdisciplinary Discussion
    Apichai Wattanapisit, Marisa Poomiphak Na Nongkhai, Poramet Hemarachatanon, Soontaraporn Huntula, Areekul Amornsriwatanakul, Chirawat Paratthakonkun, Chirk Jenn Ng
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  • Usability and utility of eHealth for physical activity counselling in primary health care: a scoping review
    Apichai Wattanapisit, Titiporn Tuangratananon, Sanhapan Wattanapisit
    BMC Family Practice.2020;[Epub]     CrossRef
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  • 199 Download
  • 21 Web of Science
  • 23 Crossref
Foregut Diverticula
Simon Roh
Korean J Fam Med 2021;42(3):191-196.   Published online October 29, 2019
DOI: https://doi.org/10.4082/kjfm.18.0092
Diverticular disease can present anywhere along the gastrointestinal (GI) tract. It can result from various pathologies such as abnormal contraction within the GI tract or inflammation causing scar tissue and the resulting forces surrounding the GI tract. Its clinical presentation can vary from asymptomatic to severe symptoms, with significant decrease in quality of life. The treatment for various diverticula along the GI tract can also vary, depending on the severity of symptoms. This article describes diverticular disease occurring within the foregut, with emphasis on pathophysiology, clinical presentation, and treatment.
  • 33,887 View
  • 158 Download
Exercise Strategies to Prevent Hypoglycemia in Patients with Diabetes
Ah Reum Jung, Hyunah Kim, Hun-Sung Kim, Churlmin Kim, Whan-Seok Choi
Korean J Fam Med 2021;42(2):91-95.   Published online May 13, 2020
DOI: https://doi.org/10.4082/kjfm.19.0043
The importance of adopting healthy exercise routines has been repeatedly emphasized to individuals with diabetes mellitus (DM). However, knowledge about the risk of exercise-induced hypoglycemia is limited. Regular exercise reduces and delays the onset of DM-related complications particularly in individuals who already have DM. However, an excessive exercise can lead to hypoglycemia. Excessive exercise in the evening can cause hypoglycemia while sleeping. Furthermore, if individuals with DM want to have a greater amount of exercise, the exercise duration rather than intensity must be increased. In weight resistance exercises, it is beneficial to first increase the number of repetitions, followed by the number of sets and gradually the weight of resistance. When performing intermittent high-intensity training within a short time period, hypoglycemia may develop for an extended period after exercise. In addition to adjusting exercise regimens, the medication doses must be modified accordingly. Delaying exercise, adjusting the number of snacks consumed prior to exercise, reducing insulin dose before exercise, and injecting insulin into the abdomen rather than the limbs prevent exercise-induced hypoglycemia prior to a spontaneous exercise. Ultimately, with personal knowledge on how to prevent hypoglycemia, the effects of exercise can be maximized in individuals with DM, and a healthy lifestyle can prevent future complications.

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  • Wearable Electrochemical Sensor for Sweat‐Based Potassium Ion and Glucose Detection in Exercise Health Monitoring
    Lei Ma, Wenhao Hou, Zhi Ji, Ziheng Sun, Muxi Li, Bolin Lian
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    Marul Ivandic, Maja Cigrovski Berkovic, Klara Ormanac, Dea Sabo, Tea Omanovic Kolaric, Lucija Kuna, Vjera Mihaljevic, Silvija Canecki Varzic, Martina Smolic, Ines Bilic-Curcic
    International Journal of Environmental Research and Public Health.2023; 20(6): 4966.     CrossRef
  • Minimizing Hypoglycemia with Insulin Therapy
    Gagan Priya, Emmy Grewal
    Chronicle of Diabetes Research and Practice.2022; 1(2): 76.     CrossRef
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  • 2 Web of Science
  • 3 Crossref
Fruit Intake to Prevent and Control Hypertension and Diabetes
Hyun Ah Park
Korean J Fam Med 2021;42(1):9-16.   Published online January 20, 2021
DOI: https://doi.org/10.4082/kjfm.20.0225
Fruits are considered healthy because of their high antioxidant, vitamin, mineral, fiber, and phytochemical contents. However, their high sugar content is a concern for glucose, lipid, and uric acid metabolism. We reviewed related articles published in the last 10 years and summarized evidence that relates fruit intake to the prevention and control of hypertension and diabetes mellitus. Clinicians should familiarize themselves with appropriate fruit intake to counsel at-risk patients on hypertension and diabetes.

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  • Associations between the Global Diet Quality Score and risk of type 2 diabetes: Tehran lipid and glucose study
    Shahrzad Daei, Firoozeh Hosseini-Esfahani, Azam Ildarabadi, Parvin Mirmiran, Fereidoun Azizi, Meisam Akhlaghdoust
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  • Is breakfast consumption detrimental, unnecessary, or an opportunity for health promotion? A review of cardiometabolic outcomes and functional food choices
    Heitor O. Santos, Grant M. Tinsley
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  • Undiagnosed hypertension and associated factors among adult population in central zone of Tigray, Northern Ethiopia 2020: A cross‐sectional study
    Haftea Hagos Mekonen, Tsegu Hailu Gebru, Kbrom Gemechu Kiros, Tesfay Gebreslassie Gebrehiwot, Yohannes Ashebir Tesfamichael
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    Sushma Chapagain, Nabin Pathak, Kushal Subedi, Prakash Ghimire, Bijay Adhikari, Niranjan Shrestha, Nim Bahadur Dangi, Naeem Mubarak
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  • The Diet Quality of Athletes as Measured by Diet Quality Indices: A Scoping Review
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    Zongyan Song, Xiong Xiong, Gangliang Huang
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    Rosnah Ismail, Noor Hassim Ismail, Zaleha Md Isa, Azmi Mohd Tamil, Mohd Hasni Ja'afar, Nafiza Mat Nasir, Suraya Abdul-Razak, Najihah Zainol Abidin, Nurul Hafiza Ab Razak, Philip Joseph, Khairul Hazdi Yusof
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  • Effects of fresh vs dried mango consumption on satiety and postprandial glucose in healthy adults
    Candice Stamper, Sama Safadi, Andrew Gehr, Pia Asuncion, Mee Young Hong
    Metabolism Open.2023; 19: 100253.     CrossRef
  • Revisiting Fruit Allergy: Prevalence across the Globe, Diagnosis, and Current Management
    Thanachit Krikeerati, Pongsawat Rodsaward, Jutamard Nawiboonwong, Kanokkarn Pinyopornpanish, Songwut Phusawang, Mongkhon Sompornrattanaphan
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    Nurul Fatin Malek Rivan, Suzana Shahar, Nik Nur Izzati Nik Mohd Fakhruddin, Yee Xing You, Normah Che Din, Roslee Rajikan
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    Soo Young Kim
    Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef
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    Seung-Won Oh
    Journal of the Korean Medical Association.2022; 65(12): 801.     CrossRef
  • Role of Indian Fruits in the Prevention and Management of Hypertension
    Pankaj Prabhakar
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    Lijing Shao, Yan Ren, Yanming Li, Mei Yang, Bing Xiang, Liping Hao, Xuefeng Yang, Jing Zeng
    Nutrients.2021; 14(1): 125.     CrossRef
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Benign Hepatic Tumors: From Incidental Imaging Finding to Clinical Management
Fadi Abu Baker, Abdel-Rauf Zeina, Saif Abu Mouch, Amir Mari
Korean J Fam Med 2021;42(1):2-8.   Published online May 27, 2020
DOI: https://doi.org/10.4082/kjfm.18.0188
Benign hepatic tumors (BHTs) are commonly detected as incidental finding mainly due to the frequent utilization of imaging modalities, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Rigorous clinical evaluation, with a particular focus on chronic liver disease (CLD) or risk factors for CLD, medication history, physical examination for signs of CLD, blood tests, and a review of past liver radiology constitute the initial steps in the evaluation of a new liver lesion. Further, contrast-enhanced imaging using US, CT and MRI, can be used depending on the clinical scenario and their availability. The contrast-enhanced MRI provides detailed tissue assessment while avoiding exposure to radiations, although it is scarcely available and expensive. While the liver tissue-specific protocols ensure precise diagnosis, a biopsy is recommended in selected or doubtful cases. Further, most BHTs, such as hemangiomas, are harmless and do not require special management or followup, the hepatic adenomas and large or atypical cases of focal nodular hyperplasia are clinically relevant and require management/follow-up. In such cases, it is favorable to have a multidisciplinary team approach, which includes hepatologist, radiologist, hepatobiliary surgeon, and pathologist. This review aims to elaborate the current understanding of BHTs, and provide a practical guidance for primary care and practitioners of family and internal medicine for the disease evaluation and management.

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Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks
Jung Ha Park, Ji Hyun Moon, Hyeon Ju Kim, Mi Hee Kong, Yun Hwan Oh
Korean J Fam Med 2020;41(6):365-373.   Published online November 19, 2020
DOI: https://doi.org/10.4082/kjfm.20.0165
One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8.3 hours among the Korean population and 7.7 hours among the American adult population. Sedentary lifestyles are spreading worldwide because of a lack of available spaces for exercise, increased occupational sedentary behaviors such as office work, and the increased penetration of television and video devices. Consequently, the associated health problems are on the rise. A sedentary lifestyle affects the human body through various mechanisms. Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. Furthermore, it decreases cardiac output and systemic blood flow while activating the sympathetic nervous system, ultimately reducing insulin sensitivity and vascular function. It also alters the insulin-like growth factor axis and the circulation levels of sex hormones, which elevates the incidence of hormone-related cancers. Increased sedentary time impairs the gravitostat, the body’s weight homeostat, and weight gain, adiposity, and elevated chronic inflammation caused by sedentary behavior are risk factors for cancer. Sedentary behaviors have wide-ranging adverse impacts on the human body including increased all-cause mortality, cardiovascular disease mortality, cancer risk, and risks of metabolic disorders such as diabetes mellitus, hypertension, and dyslipidemia; musculoskeletal disorders such as arthralgia and osteoporosis; depression; and, cognitive impairment. Therefore, reducing sedentary behaviors and increasing physical activity are both important to promote public health.

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The Impact of Heated Tobacco Products on Smoking Cessation, Tobacco Use, and Tobacco Sales in South Korea
Cheol Min Lee
Korean J Fam Med 2020;41(5):273-281.   Published online September 18, 2020
DOI: https://doi.org/10.4082/kjfm.20.0140
Heated tobacco products (HTPs), a hybrid between conventional and electronic cigarettes, were first launched in South Korea in June 2017. Owing to advertisements stating that HTPs are odorless, tar-free, and less harmful to health, the sales of HTPs have grown quickly enough to account for about 10% of the total tobacco market in a year. HTP use by young, highly educated, and high-income groups had a significant impact on both the overall tobacco market over the past 3 years and the smoking and quitting behaviors of smokers. Based on national smoking rate statistics, tobacco sales trends, and the number of visitors to smoking cessation clinics, the following changes have been identified: (1) The decline in current smoking rates has slowed or rose in some groups. (2) The decline in total cigarette sales has slowed but rose again in the first quarter of 2020. (3) The number of visitors to smoking cessation clinics decreased just after the advent of HTPs. These results may be due to the insufficient support of tobacco regulation policies but also coincide chronologically with the appearance of HTPs in South Korea. It is necessary to investigate the usage rate of various tobacco products, including HTPs and e-cigarettes, to examine the health risks of novel tobacco products and provide accurate information to users and policymakers. Finally, tobacco companies are continuously developing new product concepts to escape the regulation of existing cigarettes; thus, comprehensive management measures for all nicotine-containing products are needed.

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Diagnosis and Management of Frailty in Primary Health Care
Chang Won Won
Korean J Fam Med 2020;41(4):207-213.   Published online July 20, 2020
DOI: https://doi.org/10.4082/kjfm.20.0122
Disability in older adults has become a significant burden, both individually and socially, due to the rapidly aging population in Korea. It is important to manage both frailty and chronic diseases to delay disability. Frailty, which is considered to be a transition phase between healthy status and disability, is defined as a significant decline in functional reserves of multiple organ systems and the resultant extreme vulnerability to stressors, leading to a higher risk of adverse health-related outcomes. The frailty phenotype and frailty index are the most commonly used methods to diagnose frailty. Frailty is related to physical, psychological, cognitive, and social dysfunction, and is sometimes caused by chronic disease. Therefore, primary care providers are ideally situated to incorporate the concept of frailty into their practice, as they are champions in comprehensive care. Although the identification and treatment of frailty is not yet standard practice in primary care, primary care physicians must use the electronic frailty index to identify frailty in all the patients aged ≥65 years in the United Kingdom. In Canada, some insurance companies and governments are using a similar program, which is called the Community Actions and Resources Empowering Seniors model. The clinical practice guidelines of the International Conference of Frailty and Sarcopenia Research, as well as some additional references, will be introduced. Here, we review the current literature on how to diagnose and manage frailty in primary care.

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Conducting and Reporting a Clinical Research Using Korean Healthcare Claims Database
Seonji Kim, Myo-Song Kim, Seung-Hun You, Sun-Young Jung
Korean J Fam Med 2020;41(3):146-152.   Published online May 20, 2020
DOI: https://doi.org/10.4082/kjfm.20.0062
An increasing number of studies are using healthcare claims databases to assess healthcare intervention utilization patterns or outcomes in real-world clinical settings. However, methodological issues affecting study design or data analysis can make conducting and reporting these types of studies difficult. This review presents an overview of the types of information contained in claims data, describes some advantages and limitations of using claims data for research purposes, and outlines steps for utilizing the Korea Health Insurance Review and Assessment and National Health Insurance Service databases. The study also reviews epidemiological approaches utilizing healthcare claims databases (including cross-sectional, case-control, case-crossover, and cohort designs) with respect to protocol development, analysis, and reporting of results, and introduces relevant guidelines and checklists, including the Guidelines for Good Pharmacoepidemiology Practices, the Strengthening the Reporting of Observational Studies in Epidemiology checklist, and the Risk of Bias in Nonrandomized Studies of Interventions tool.

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Chronic Constipation in the Elderly Patient: Updates in Evaluation and Management
Amir Mari, Mahmud Mahamid, Hana Amara, Fadi Abu Baker, Afif Yaccob
Korean J Fam Med 2020;41(3):139-145.   Published online February 17, 2020
DOI: https://doi.org/10.4082/kjfm.18.0182
Chronic constipation (CC) is a common disorder in the elderly population globally and is associated with comorbidities and negative implications on the quality of life. Constipation prevalence varies in different studies, primarily owing to the nonuniformity of the diagnostic criteria. However, 15%–30% of individuals aged >60 years are diagnosed with CC. Primary care physicians are the main healthcare providers that manage constipation in elderly patients in parallel with increased population aging and increased prevalence of constipation. Physical inactivity, polypharmacy, chronic medical conditions, rectal hyposensitivity, and defecatory disorders all play a role in the pathogenesis of CC in elderly patients. Detailed anamnesis, particularly history related to chronic medication use, with digital rectal examination may assist in identifying constipation causes. Additionally, blood tests and colonoscopy may identify organic causes of CC. Physiologic tests (i.e., anorectal manometry, colonic transit time with radiopaque markers, and defecography) can evaluate the physiologic function of the colon, rectum, and anus. However, generally, there are several causes of constipation in older patients, and an individualized approach is recommended. Treatment of chronic idiopathic constipation is empiric, based on the stepwise approach. Lifestyle advice, adjustment of chronic medications, and prescription of laxatives are the first steps of management. Several laxatives are available, and the treatment is evolving in the last decade. Biofeedback is an effective therapy especially for defecatory disorders. This review aimed to summarize the most updated knowledge for primary care physicians in the approach and management of CC in elderly patients.

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Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
Amir Mari, Emmanouela Tsoukali, Afif Yaccob
Korean J Fam Med 2020;41(2):75-83.   Published online February 17, 2020
DOI: https://doi.org/10.4082/kjfm.18.0162
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this condition as a new and distinct clinicopathological entity 25 years ago. Clinical presentation in adult patients may include dysphagia, food impaction, vomiting, and reflux symptoms. The diagnosis of EoE is based on the combination of clinical history suggestive of esophageal dysfunction, endoscopic features indicative of the disease, and histology revealing eosinophilic infiltration of the esophageal epithelium that persists after a trial of proton pump inhibitor therapy along with the exclusion of other disorders that may be associated with esophageal tissue eosinophilia. The interplay between EoE and gastroesophageal reflux disease (GERD) is complex, and differentiating these two conditions continues to be difficult and challenging in clinical practice. The mainstay treatment includes dietary modification, topical steroids, and/or endoscopic dilation. The primary care physician (PCP) plays an important role in improving patient care and quality of life by ensuring early referral and participating in management and follow-up. This article provides an overview of the current knowledge base regarding the disease including epidemiology, genetics, pathogenesis, common clinical presentations, the interplay between EoE and GERD, diagnostic approaches, and therapeutic options available to the PCP.

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Cigarette Smoking in South Korea: A Narrative Review
Rebekah Gunter, Edwin Szeto, Se-Hoon Jeong, Sooyeon (Aly) Suh, Andrew J. Waters
Korean J Fam Med 2020;41(1):3-13.   Published online June 13, 2019
DOI: https://doi.org/10.4082/kjfm.18.0015
Although the prevalence of cigarette smoking has declined in Western countries over the past few decades, a comparable decline among males has not been observed in Asian countries, especially in South Korea, where approximately 40%–50% of men and 4%–8% of women have been identified as smokers, and there is a pressing need to understand the background of cigarette smoking in these populations. The present study is a narrative review of the research literature on cigarette smoking in South Korea. First, we describe the social, economic, and cultural factors that impact cigarette smoking in South Korea. The paper also reviews the available peer-reviewed literature comprising observational studies and interventional studies, including randomized controlled trials. The extant literature on smoking in Korean Americans is also reviewed. Cigarette smoking in South Korea has been relatively understudied, and this review identifies priority areas for future research, including the use of mobile interventions.

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    Communication Studies.2021; 72(5): 937.     CrossRef
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Cancer Survivorship in Primary Care
Jihun Kang, Eun Ju Park, Jungkwon Lee
Korean J Fam Med 2019;40(6):353-361.   Published online November 20, 2019
DOI: https://doi.org/10.4082/kjfm.19.0108
With the early detection of cancer and improvement in cancer therapy, the number of cancer survivors is rapidly increasing. This number is expected to reach 2 million by the end of 2019. Cancer survivors struggle with not only cancer-related health problems but also diverse acute and chronic diseases. These health issues make cancer survivorship more complex, and proper care coordination is necessary. This study aimed to summarize the definition of cancer experience and management of cancer survivors, specifically focused on gastric, colorectal, lung, breast, thyroid, prostate, and cervical cancers. Furthermore, it aimed to discuss the role of primary care in cancer survivorship and survivorship care models and the National Policy for Cancer Survivors and Future Challenges.

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  • Supporting Life Adjustment in Patients With Lung Cancer Through a Comprehensive Care Program: Protocol for a Controlled Before-and-After Trial
    Wonyoung Jung, Alice Ahn, Genehee Lee, Sunga Kong, Danbee Kang, Dongok Lee, Tae Eun Kim, Young Mog Shim, Hong Kwan Kim, Jongho Cho, Juhee Cho, Dong Wook Shin
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    Korean Journal of Family Medicine.2023; 44(4): 224.     CrossRef
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    Stacey L. Worrell, Michelle L. Kirschner, Rhonna S. Shatz, Soma Sengupta, Melissa G. Erickson
    Current Oncology Reports.2021;[Epub]     CrossRef
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  • 149 Download
  • 6 Web of Science
  • 5 Crossref
Recent Advances in Anti-Aging Medicine
Da-Hye Son, Woo-Jin Park, Yong-Jae Lee
Korean J Fam Med 2019;40(5):289-296.   Published online September 20, 2019
DOI: https://doi.org/10.4082/kjfm.19.0087
A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging process and its associated effects, such as disability and frailty. Anti-aging medicine is emerging as a growing industry, but many supplements or protocols are available that do not have scientific evidence to support their claims. In this review, the mechanisms of action and the clinical implications of anti-aging interventions were examined and explained. Calorie restriction mimetics define compounds that imitate the outcome of calorie restriction, including an activator of AMP protein kinase (metformin), inhibitor of growth hormone/insulin-like growth factor-1 axis (pegvisomant), inhibitor of mammalian target of rapamycin (rapamycin), and activator of the sirtuin pathway (resveratrol). Hormonal replacement has also been widely used in the elderly population to improve their quality of life. Manipulating healthy gut microbiota through prebiotic/probiotics or fecal microbiota transplantation has significant potential in anti-aging medicine. Vitamin D is expected to be a primary anti-aging medicine in the near future due to its numerous positive effects in the elderly population.

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Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing
Sami Lee, Jong-Sung Kim, Jin-Gyu Jung, Mi-Kyeong Oh, Tae-Heum Chung, Jihan Kim
Korean J Fam Med 2019;40(4):204-211.   Published online July 15, 2019
DOI: https://doi.org/10.4082/kjfm.19.0059
This study investigated advantages and potential risks associated with drinking alcohol in Koreans based on the alcohol flush reaction. Our investigation reviewed published studies and examined moderate-drinking levels for Koreans based on modified National Institute on Alcohol Abuse and Alcoholism guidelines. Fourteen articles out of a total 198 publications were searched using PubMed, EMBASE, KoreaMed, and RISS (Research Information Sharing Service) databases and selected for review. Individuals without alcohol flush reaction (non-flushers) exhibited lower risks associated with insulin resistance, metabolic syndrome, and hyperhomocysteinemia and their 10-year cardiovascular disease risk when alcohol consumption was ≤8 drinks/wk. Conversely, risks associated with insulin resistance, metabolic syndrome, high blood pressure, prediabetes or type-2 diabetes, and high intraocular pressure and increases in carbohydrate-deficient transferrin, gamma glutamyl transferase, and blood glucose levels were present when >8 drinks were consumed. For individuals with flushing reaction (flushers), advantages were reported in relation to risks of hyperhomocysteinemia when alcohol consumption was ≤4 drinks/wk, whereas consumption of >4 drinks/wk increased the risk of insulin resistance, metabolic syndrome, high blood pressure, pre-diabetes or type-2 diabetes, high-risk colorectal adenoma, and high intraocular pressure and increased carbohydrate-deficient transferrin, gamma glutamyl transferase, and blood glucose levels. The moderate drinking level for Koreans is ≤8 drinks/wk for men aged ≤65 years and ≤4 drinks/wk for men aged over 65. For women, these limits should be half of those for men. Furthermore, individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.

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An Overview of Current Physical Activity Recommendations in Primary Care
Yun Jun Yang
Korean J Fam Med 2019;40(3):135-142.   Published online May 20, 2019
DOI: https://doi.org/10.4082/kjfm.19.0038
Primary care physicians should encourage their patients to engage in adequate physical activity. Current recommendations for physical activity in adults are as follows: at least 150–300 minutes per week of moderate-intensity, 75–150 minutes per week of vigorous-intensity aerobic physical activity, or an equivalent combination of moderate- and vigorous-intensity aerobic activity. Adults should also perform muscle-strengthening activities of moderate intensity or higher that involve all major muscle groups for 2 or more days per week. The elderly should perform additional balance training and fall prevention exercises more than 3 times a week. Children and adolescents should perform at least 1 hour of moderate-to-vigorous physical activity daily, which includes vigorous aerobic activity at least 3 days per week. As part of their 60 minutes or more of daily physical activity, resistance training and bone strengthening exercise should be done at least 3 days per week. According to new evidence, one bout of any exercises can be shorter than 10 minutes. Previously, physical activities were recommended for more than 10 minutes. For patients with diabetes, it is advisable to perform resistance exercise or short-distance running before aerobic exercise to prevent hypoglycemia. New evidence shows that dynamic resistance training is safe and effective in patients with hypertension provided the load is not too heavy. Exercise reduces pain and improves quality of life and physical function in patients with osteoarthritis,. Therefore, the treatment guidelines for osteoarthritis have been changed recently from not recommending exercise to highly recommending it.

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The Korean Ministry of Food and Drug Safety has approved three anti-obesity drugs for long-term management in the past decade. In addition, since 2019, bariatric surgery has been financially supported by National Health Insurance Service in Korea. In this review, the mechanisms of action and the clinical implications of the recently approved anti-obesity drugs, lorcaserin, naltrexone/bupropion, and liraglutide are explained. Lorcaserin stimulates proopiomelanocortin (POMC)/cocaine- and amphetamine-regulated transcript (CART) neurons and inhibits neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons, which results in the activation of melanocortin 3/4 receptors. Naltrexone/bupropion stimulates POMC neurons through bupropion; this stimulation is augmented by blocking the autoinhibitory mechanism of POMC with naltrexone. The hypophagic effect of liraglutide is mediated through the direct activation of POMC/CART neurons and the indirect suppression of NPY/AgRP neurons through γ-aminobutyric acid-dependent signaling, with adjunctive suppression of the mesolimbic dopamine reward system. In addition to liraglutide, another glucagon-like peptide-1 receptor agonist, semaglutide, is expected to be added to the list of anti-obesity drugs in the near future. In patients with obesity and high cardiovascular risk, lorcaserin was considered neutral and liraglutide was considered favorable, whereas inconclusive results were obtained for naltrexone/bupropion.

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The Bidirectional Relationship between Diabetes and Depression: A Literature Review
Abdallah Alzoubi, Rnad Abunaser, Adi Khassawneh, Mahmoud Alfaqih, Aws Khasawneh, Nour Abdo
Korean J Fam Med 2018;39(3):137-146.   Published online May 18, 2018
DOI: https://doi.org/10.4082/kjfm.2018.39.3.137
Diabetes is a major public health problem worldwide. Depression is a serious mental condition that decreases mental and physical functioning and reduces the quality of life. Several lines of evidence suggest a bidirectional relationship between diabetes and depression: diabetes patients are twice as likely to experience depression than nondiabetic individuals. In contrast, depression increases the risk of diabetes and interferes with its daily self-management. Diabetes patients with depression have poor glycemic control, reduced quality of life, and an increased risk of diabetes complications, consequently having an increased mortality rate. Conflicting evidence exists on the potential role of factors that may account for or modulate the relationship between diabetes and depression. Therefore, this review aims to highlight the most notable body of literature that dissects the various facets of the bidirectional relationship between diabetes and depression. A focused discussion of the proposed mechanisms underlying this relationship is also provided. We systematically reviewed the relevant literature in the PubMed database, using the keywords “Diabetes AND Depression”. After exclusion of duplicate and irrelevant material, literature eligible for inclusion in this review was based on meta-analysis studies, clinical trials with large sample sizes (n≥1,000), randomized clinical trials, and comprehensive national and cross-country clinical studies. The evidence we present in this review supports the pressing need for long, outcome-oriented, randomized clinical trials to determine whether the identification and treatment of patients with these comorbid conditions will improve their medical outcomes and quality of life.

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Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity
Indri Adriztina, Linda Irwani Adenin, Yuliani Mardiati Lubis
Korean J Fam Med 2018;39(1):2-9.   Published online January 23, 2018
DOI: https://doi.org/10.4082/kjfm.2018.39.1.2

Chronic suppurative otitis media (CSOM) is one of the most common chronic infectious diseases worldwide, especially affecting children. The patients or the parents of the affected children are often worried about the cost of medical visits, prescription medicines, or inconsistently effective medication. The complications of CSOM have been greatly reduced because of the development of antibiotics; however, the irrational use of antibiotics has led to the emergence of organisms resistant to the commonly used drugs. Owing to the increase in antibiotic resistance, the development of new treatments that will efficiently eradicate infectious microorganisms has become imperative. Boric acid solutions are effective in the treatment of CSOM because of their acidic effect. Various databases, such as the PubMed, The Cochrane Library, and SciELO, were searched for references related to the efficacy of boric acid in the treatment of mucosal CSOM, as well as its ototoxicity. The search revealed that boric acid is relatively effective in treating CSOM, especially at a high concentration. Boric acid in distilled water was found safe in animal studies. However, the ototoxicity of boric acid concentrations higher than 4% needs further evaluation, considering the effectivity of boric acid at high concentrations.

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    Abdulkadir ŞAHİN, Ayhan KARS, Korhan KILIÇ, Muhammed Sedat SAKAT, Sinan KÖYCEĞİZ, Serkan YİLDİRİM
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Probability or Reasoning: Current Thinking and Realistic Strategies for Improved Medical Decisions
Yogarabindranath Swarna Nantha
Korean J Fam Med 2017;38(6):315-321.   Published online November 14, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.6.315

A prescriptive model approach in decision making could help achieve better diagnostic accuracy in clinical practice through methods that are less reliant on probabilistic assessments. Various prescriptive measures aimed at regulating factors that influence heuristics and clinical reasoning could support clinical decision-making process. Clinicians could avoid time-consuming decision-making methods that require probabilistic calculations. Intuitively, they could rely on heuristics to obtain an accurate diagnosis in a given clinical setting. An extensive literature review of cognitive psychology and medical decision-making theory was performed to illustrate how heuristics could be effectively utilized in daily practice. Since physicians often rely on heuristics in realistic situations, probabilistic estimation might not be a useful tool in everyday clinical practice. Improvements in the descriptive model of decision making (heuristics) may allow for greater diagnostic accuracy.

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